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Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.
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1

2-Pyrid-4-ylpyrimidine-5-carboxylic acid, 90%, Thermo Scientific™

CAS: 259807-47-1 Molecular Formula: C10H7N3O2 Molecular Weight (g/mol): 201.185 MDL Number: MFCD09863218 InChI Key: GTKJGOOMSODGOU-UHFFFAOYSA-N Synonym: 2-pyridin-4-yl pyrimidine-5-carboxylic acid,2-pyrid-4-ylpyrimidine-5-carboxylic acid,5-pyrimidinecarboxylicacid, 2-4-pyridinyl,2-4-pyridyl pyrimidine-5-carboxylic acid,2-4-pyridinyl-5-pyrimidinecarboxylic acid,2-pyridin-4-yl-pyrimidine-5-carboxylic acid,5-pyrimidinecarboxylic acid, 2-4-pyridinyl,5-pyrimidinecarboxylic acid, 2-4-pyridinyl-9ci PubChem CID: 22710213 IUPAC Name: 2-pyridin-4-ylpyrimidine-5-carboxylic acid SMILES: C1=CN=CC=C1C2=NC=C(C=N2)C(=O)O

PubChem CID 22710213
CAS 259807-47-1
Molecular Weight (g/mol) 201.185
MDL Number MFCD09863218
SMILES C1=CN=CC=C1C2=NC=C(C=N2)C(=O)O
Synonym 2-pyridin-4-yl pyrimidine-5-carboxylic acid,2-pyrid-4-ylpyrimidine-5-carboxylic acid,5-pyrimidinecarboxylicacid, 2-4-pyridinyl,2-4-pyridyl pyrimidine-5-carboxylic acid,2-4-pyridinyl-5-pyrimidinecarboxylic acid,2-pyridin-4-yl-pyrimidine-5-carboxylic acid,5-pyrimidinecarboxylic acid, 2-4-pyridinyl,5-pyrimidinecarboxylic acid, 2-4-pyridinyl-9ci
IUPAC Name 2-pyridin-4-ylpyrimidine-5-carboxylic acid
InChI Key GTKJGOOMSODGOU-UHFFFAOYSA-N
Molecular Formula C10H7N3O2
2

5-Bromo-2-tert-butylpyrimidine 98.0+%, TCI America™

CAS: 85929-94-8 Molecular Formula: C8H11BrN2 Molecular Weight (g/mol): 215.09 MDL Number: MFCD00235040 InChI Key: FAAQGONYZKWBKC-UHFFFAOYSA-N PubChem CID: 13532898 IUPAC Name: 5-bromo-2-tert-butylpyrimidine SMILES: CC(C)(C)C1=NC=C(Br)C=N1

PubChem CID 13532898
CAS 85929-94-8
Molecular Weight (g/mol) 215.09
MDL Number MFCD00235040
SMILES CC(C)(C)C1=NC=C(Br)C=N1
IUPAC Name 5-bromo-2-tert-butylpyrimidine
InChI Key FAAQGONYZKWBKC-UHFFFAOYSA-N
Molecular Formula C8H11BrN2
3

4-Chloro-2-(methylthio)pyrimidine 98.0+%, TCI America™

CAS: 49844-90-8 Molecular Formula: C5H5ClN2S Molecular Weight (g/mol): 160.62 MDL Number: MFCD00006083 InChI Key: DFOHHQRGDOQMKG-UHFFFAOYSA-N Synonym: 4-chloro-2-methylthio pyrimidine,4-chloro-2-methylthiopyrimidine,4-chloro-2-methylsulfanyl pyrimidine,4-chloro-2-methylsulfanyl-pyrimidine,pyrimidine, 4-chloro-2-methylthio,4-chloro-2-methylmercapto pyrimidine,zlchem 575,pubchem15403,pubchem15764,acmc-1asbn PubChem CID: 97113 IUPAC Name: 4-chloro-2-(methylsulfanyl)pyrimidine SMILES: CSC1=NC=CC(Cl)=N1

PubChem CID 97113
CAS 49844-90-8
Molecular Weight (g/mol) 160.62
MDL Number MFCD00006083
SMILES CSC1=NC=CC(Cl)=N1
Synonym 4-chloro-2-methylthio pyrimidine,4-chloro-2-methylthiopyrimidine,4-chloro-2-methylsulfanyl pyrimidine,4-chloro-2-methylsulfanyl-pyrimidine,pyrimidine, 4-chloro-2-methylthio,4-chloro-2-methylmercapto pyrimidine,zlchem 575,pubchem15403,pubchem15764,acmc-1asbn
IUPAC Name 4-chloro-2-(methylsulfanyl)pyrimidine
InChI Key DFOHHQRGDOQMKG-UHFFFAOYSA-N
Molecular Formula C5H5ClN2S
4

Medchemexpress LLC CB096 | 108883-90-5 | 98.7% | 285.25 g·mol⁻¹ | C14H11N3O4 | 250 MG
SDP

CB096 is a small-molecule RNA translation inhibitor that binds the 5′CGG/3′GGC internal loop of r(G4C2)exp RNA, disrupting its gain-of-function mechanism and reducing production of toxic dipeptide repeats. It inhibits RAN translation in cell assays (IC50 = 20 μM in HEK293T) and modulates RNA splicing and nucleocytoplasmic transport.

  • Inhibits RAN translation in cells (IC50 = 20 μM in HEK293T).
  • Binds the 5′CGG/3′GGC internal loop of r(G4C2)exp RNA.
  • High purity of 98.72%.
  • Solid, yellow to orange appearance.
  • Soluble in DMSO at 50 mg/mL.
  • Storage: sealed, away from moisture; in solvent -80°C (6 months) or -20°C (1 month).
  • Available in multiple quantities for research use.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC 2-Methyl-5-HT | 78263-90-8 | 98.9% | 190.24 | 25 MG
SDP

2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. It has been shown to display anti-depressive-like effects.

  • Potent and selective 5-HT3 receptor agonist.
  • Shown to display anti-depressive-like effects.

ENCOMPASS_PREFERRED
6

Medchemexpress LLC WYE-687 | 1062161-90-3 | C28H32N8O3 | 5 MG
SDP

WYE-687 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. It concurrently inhibits the activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC50s of 81 nM and 3.11 μM, respectively.

  • ATP-competitive mTOR inhibitor
  • Inhibits activation of mTORC1 and mTORC2
  • Inhibits PI3Kα and PI3Kγ
  • Potently inhibits HL-60 cell survival
  • Cytotoxic to U937, THP-1 and AML-193 AML cell lines
  • Significantly inhibits U937 xenograft tumor growth in SCID mice

ENCOMPASS_PREFERRED
7

Medchemexpress LLC 4-trifluoromethylsalicylic acid | 328-90-5 | MFCD01529657 | 99.9% | 206.12 g/mol | C8H5F3O3 | 250 MG
SDP

4-Trifluoromethylsalicylic acid (desacetyl triflusal) is a research-grade small molecule described as a platelet aggregation inhibitor. Supplied as a solid, it has the molecular formula C8H5F3O3 and a molecular weight of 206.12 g/mol. Intended for laboratory research use only, the material is provided with a high assay purity and recommended storage to maintain stability.

  • White to off-white solid suitable for analytical and biological research.
  • Molecular formula C8H5F3O3; molecular weight 206.12 g/mol.
  • High purity (99.93%) for reproducible experimental results.
  • Stable when stored as powder at 4°C for 2 years or -20°C for 3 years.
  • Used as a platelet aggregation inhibitor and as a metabolite/reference in mechanistic studies.

ENCOMPASS_PREFERRED
8

STA PHARMACEUTICAL US LLC 2’-OTBS Pyrimidinone amidite | 5 g | CAS 155831-90-6 | MDL MFCD08062082

2’-OTBS Pyrimidinone amidite is a Amidite reagent (Subcategory: Specialty Base Modification) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 155831-90-6
- MDL: MFCD08062082
- InChIKey: UEUDLVPTCOPGMZ-MGVQLQBBSA-N
- Molecular Weight: 845.061761998
- Molecular Formula: C45H61N4O8PSi
- Purity: ≥95%
- Container Type: 250 mL Glass (28-400)
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 174.7 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C(C)(C)C)C)N2C(N=CC=C2)=O)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=CC=C5)OCCC#N)C(C)C)C

ENCOMPASS
9

STA PHARMACEUTICAL US LLC 2’-OTBS Pyrimidinone amidite | 5 g | CAS 155831-90-6 | MDL MFCD08062082

2’-OTBS Pyrimidinone amidite is a Amidite reagent (Subcategory: Specialty Base Modification) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 155831-90-6
- MDL: MFCD08062082
- InChIKey: UEUDLVPTCOPGMZ-MGVQLQBBSA-N
- Molecular Weight: 845.061761998
- Molecular Formula: C45H61N4O8PSi
- Purity: ≥95%
- Container Type: 100 mL Glass (Septum)
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 100.4 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C(C)(C)C)C)N2C(N=CC=C2)=O)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=CC=C5)OCCC#N)C(C)C)C

ENCOMPASS
10

STA PHARMACEUTICAL US LLC 2’-OTBS Pyrimidinone amidite | 5 g | CAS 155831-90-6 | MDL MFCD08062082

2’-OTBS Pyrimidinone amidite is a Amidite reagent (Subcategory: Specialty Base Modification) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 155831-90-6
- MDL: MFCD08062082
- InChIKey: UEUDLVPTCOPGMZ-MGVQLQBBSA-N
- Molecular Weight: 845.061761998
- Molecular Formula: C45H61N4O8PSi
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C(C)(C)C)C)N2C(N=CC=C2)=O)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=CC=C5)OCCC#N)C(C)C)C

ENCOMPASS
11

Sigma Aldrich (2-Methoxy-1-pyridin-2-ylethyl)methylamine

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

ENCOMPASS ENCOMPASS_PREFERRED
CAS 959238-90-5
12

Apexbio Technology LLC Rofecoxib 162011-90-7 250mg
SDP

Rofecoxib (CAS 162011-90-7) is a selective inhibitor of cyclooxygenase-2 (COX-2) designed to provide anti-inflammatory effects with improved gastrointestinal tolerance compared to non-selective NSAIDs It demonstrates potent inhibition of COX-2 in cell-based assays with IC50 values ranging from 18 to 46 nM In osteosarcoma cells Rofecoxib suppresses prostaglandin E2 (PGE2) synthesis (IC50 26 nM) and inhibits recombinant human COX-2 in stably transfected CHO cells (IC50 18 nM) In biochemical assays using purified human COX-2 the IC50 is 0 34 M In vivo Rofecoxib reduces carrageenan-induced edema and hyperalgesia in rats (ID50 1 1 5 mg/kg) It is widely used in studies investigating COX-2-mediated inflammatory pathways and analgesia

ENCOMPASS_PREFERRED
13

STA PHARMACEUTICAL US LLC 2’-OTBS Pyrimidinone amidite | 200 mg | CAS 155831-90-6 | MDL MFCD08062082

2’-OTBS Pyrimidinone amidite is a Amidite reagent (Subcategory: Specialty Base Modification) sold by WuXi TIDES. Offered in 200 mg. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 155831-90-6
- MDL: MFCD08062082
- InChIKey: UEUDLVPTCOPGMZ-MGVQLQBBSA-N
- Molecular Weight: 845.061761998
- Molecular Formula: C45H61N4O8PSi
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 200 mg
- Net Weight: 0.2 g
- Gross Weight: 6.9 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C(C)(C)C)C)N2C(N=CC=C2)=O)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=CC=C5)OCCC#N)C(C)C)C

ENCOMPASS
14

STA PHARMACEUTICAL US LLC 2’-OTBS Pyrimidinone amidite | 1 g | CAS 155831-90-6 | MDL MFCD08062082

2’-OTBS Pyrimidinone amidite is a Amidite reagent (Subcategory: Specialty Base Modification) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 155831-90-6
- MDL: MFCD08062082
- InChIKey: UEUDLVPTCOPGMZ-MGVQLQBBSA-N
- Molecular Weight: 845.061761998
- Molecular Formula: C45H61N4O8PSi
- Purity: ≥95%
- Container Type: 30 mL Glass (20-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 47.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C(C)(C)C)C)N2C(N=CC=C2)=O)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=CC=C5)OCCC#N)C(C)C)C

ENCOMPASS
15

STA PHARMACEUTICAL US LLC 2’-OTBS Pyrimidinone amidite | 1 g | CAS 155831-90-6 | MDL MFCD08062082

2’-OTBS Pyrimidinone amidite is a Amidite reagent (Subcategory: Specialty Base Modification) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.

Specifications
- CAS: 155831-90-6
- MDL: MFCD08062082
- InChIKey: UEUDLVPTCOPGMZ-MGVQLQBBSA-N
- Molecular Weight: 845.061761998
- Molecular Formula: C45H61N4O8PSi
- Purity: ≥95%
- Container Type: 60 mL Glass (Septum)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 38.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C(C)(C)C)C)N2C(N=CC=C2)=O)COC(C3=CC=C(C=C3)OC)(C4=CC=C(C=C4)OC)C5=CC=CC=C5)OCCC#N)C(C)C)C

ENCOMPASS