Pyrimidines And Derivatives

Medchemexpress LLC Benzothiazolium, 2-[2-[4-[ethyl(2-hydroxyethyl)amino]phenyl]diazenyl]-6-methoxy-3-methyl-, methyl sulfate (1:1) | 12270-13-2 | 93.5% | 250 MG

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C.I. Basic blue 41 is an alkaline dye. It can be removed from aqueous solutions using tree ferns as biosorbents in intermittent adsorption systems.

• Alkaline dye.
• Removable from aqueous solutions.
• Utilizes tree ferns as biosorbents.
• For research use only.
• Not sold to patients.

Selleck Chemical LLC B-Raf IN 1

B-Raf IN 1 is an inhibitor of Raf wih IC50 values of 24 nM and 25 nM for B-Raf and C-Raf respectively It is selective over 13 other kinases including PKC IKK and PI3K

Medchemexpress LLC HY-107643 5mg Medchemexpress, Reversan CAS:313397-13-6 Purity:>98%

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Medchemexpress, HY-107643 5mg Reversan CAS:313397-13-6 Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

Medchemexpress LLC Urocortin, rat | 171543-83-2 | 96.6% | 4707.26 | 250 MG

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Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively. It is intended for research use only.

• Potent endogenous CRFR agonist.
• Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively.
• Induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively in stably transfected Chinese hamster ovary cells.
• Decreases food intake in both food-deprived and non-deprived rats (0.01 to 10 μg) and mice (1 μg i.c.v. administration).
• Potential for inducing anxiogenic behavior.

Medchemexpress LLC TBK1/IKKε-IN-4 | 1381930-17-1 | 99.8% | 533.62 g·mol⁻¹ | C28H35N7O4 | 50MG

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TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative that potently and selectively inhibits TANK-binding kinase 1 (TBK1) and IκB kinase-ε (IKKε). Supplied as a research reagent, it is characterized for potency and purity and is available in multiple milligram-scale pack sizes for laboratory studies.

• Potent dual TBK1 and IKKε inhibitor with IC50 values of 13 nM (TBK1) and 59 nM (IKKε).
• High purity: 99.8%.
• Molecular weight 533.62 g·mol⁻¹; formula C28H35N7O4.
• Available in multiple pack sizes including 50 mg for small-scale studies.
• Intended for research use only; not for human therapeutic use.

Medchemexpress LLC 6-aminopyrazolopyrimidine derivative | 1381930-17-1 | 99.4% | 533.62 | C28H35N7O4 | 100MG

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TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine-derived small-molecule inhibitor selective for TBK1 and IKKε, intended for biochemical and cell-based research into innate immunity and inflammatory signaling. It shows nanomolar potency and is supplied as a solid for laboratory use.

• Potent TBK1 inhibition, IC50 13 nM.
• Potent IKKε inhibition, IC50 59 nM.
• High chemical purity, 99.42%.
• Solid, white to light yellow appearance.
• Stable when stored sealed, away from moisture and light; recommended in solvent: -80°C (6 months) or -20°C (1 month).
• Available in multiple package sizes, including a 100 mg pack.

Cayman Chemical ThIobarbIturIc AcId asy Rea 1g

A multi-kinase inhibitor inhibits FLT3 CSF1R c-Kit FGFR1 FGFR3 VEGFR1 -2 and -3 PDFGRa and PDGFRB (IC50s 1 36 2 8 9 10 13 8 27 and 210 nM respectively) inhibits the proliferation of human multiple myeloma cell lines expressing mutant but not wild-type FGFR3 (IC50s 90-550 and >2500 nM respectively) decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM inhibits bFGF-induced angiogenesis in a Matrigel™ plUG assay in mice at 3-300 mg/kg for 8 days reduces tumor growth in KM12L4A DU145 and MV4-11 mouse xenograft models (ED50s 17 23 and 3 mg/kg per day respectively)