Pyrimidines And Derivatives
Apexbio Technology LLC PUROMYCIN AMINONUCLEOSID 250MG
Puromycin aminonucleoside (CAS 58-60-6) is the aminonucleoside moiety derived from the antibiotic puromycin It induces nephrotic injury in experimental animal models leading to significant proteinuria and structural alterations in renal glomeruli In vitro treatment with puromycin aminonucleoside alters podocyte morphology characterized by reductions in cellular microvilli and disruption of foot-process structures In vivo administration in rats induces glomerular lesions resembling focal segmental glomerulosclerosis (FSGS) and lipid accumulation in mesangial cells This compound serves primarily as an investigative tool in elucidating mechanisms underlying nephrotic syndrome
Apexbio Technology LLC CAMPTOTHECIN 250MG
Camptothecin (CAS 7689-03-4) is a small molecule inhibitor that selectively targets topoisomerase I exhibiting an IC50 value of 679 nM It causes DNA damage evident by phosphorylation of histone H2AX ( H2AX) leading to tumor cell death and cellular senescence via the ATM-Chk2-p53-p21 signaling pathway Additionally camptothecin induces autophagy through activation of the AMPK-TSC2-mTOR pathway Preclinical studies demonstrate its anti-tumor activity against tumor cell lines such as SMMC-7721 MCF-7 HCT-116 and NSCLC xenografts underscoring its utility in cancer biology research
Apexbio Technology LLC 5-Methyl-dCTP50ul 100 mM
5-Methyl-dCTP is a chemically modified deoxynucleotide analog in which the cytosine base contains a methyl group at the carbon-5 position Cytosine methylation at this position represents a frequent epigenetic modification observed extensively in mammalian genomic DNA During polymerase chain reaction (PCR) replacing conventional dCTP with 5-methyl-dCTP permits the synthesis of methylated DNA strands facilitating controlled in vitro studies of DNA methylation mechanisms Researchers employ this nucleotide analog to examine methylation-dependent recognition and cleavage activities of certain restriction and modification enzymes Additionally intracellular delivery of 5-methyl-dCTP can lead to its genomic incorporation altering epigenetic methylation patterns and associated gene expression profiles