Pyrimidines And Derivatives
Medchemexpress LLC Calcium Phytate | 3615-82-5 | 250 MG
Calcium phytate is an insoluble phosphorus-containing compound commonly found in plant-based foods such as cereals and legumes. It can be present in feces and has shown properties to alleviate lead poisoning.
- Found extensively in plant-based foods such as cereals and legumes
- Can be present in feces
- Alleviates lead poisoning
- Reduces weight loss in lead poisoning models
- Reduces lead accumulation in the liver and kidneys
- Reverses toxic effects of lead on liver and kidney weights
Medchemexpress LLC D-Panthenol (standard) | 81-13-0 | 95.6% | 250 MG
D-Panthenol (Standard) is the analytical standard of D-Panthenol. This product is intended for research and analytical applications. D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.
- Intended for research and analytical applications.
- It is the biologically-active alcohol of pantothenic acid.
- Leads to an elevation in the amount of coenzyme A in the cell.
- Exhibits nephroprotective effect in AKI.
- Promotes tissue repair and regeneration.
Medchemexpress LLC Diethyltoluamide | 134-62-3 | 99.7% | 250 MG
Diethyltoluamide (DEET) is an analytical standard used in research and analytical applications. As the most common active ingredient in insect repellents, it provides protection against mosquitoes, ticks, fleas, chiggers, leeches, and many other biting insects. It is noted for its toxicity to hepatocytes, which can lead to various physiological, pharmacological, and behavioral abnormalities, including motor deficits and learning and memory dysfunction.
- Analytical standard for research and analytical applications
- Provides protection against mosquitoes, ticks, fleas, chiggers, and leeches
- Common active ingredient in insect repellents
- Causes toxicity in hepatocytes
- Can lead to motor deficits and learning and memory dysfunction
Medchemexpress LLC Dimercaprol | 59-52-9 | 98.0% | 250 MG
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent that also exhibits anti-HIV activity. It is used for the study of poisoning by arsenic, mercury, gold, lead, antimony, and other toxic metals.
- Anti-heavy metal-poisoning agent
- Exhibits anti-HIV activity
- Liquid appearance with a density of 1.239 g/cm³
- Colorless to off-white
- Molecular weight of 124.23
- Formula C3H8OS2
- Storage at 4°C, stored under nitrogen
- For research use only
- Can be used to study arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning
- Protects PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner in vitro
- Decreases mercury content in the liver and kidney in Wistar rats exposed to HgCl2 in vivo
Apexbio Technology LLC Calcipotriol monohydrate 147657-22-5 100mg
Calcipotriol monohydrate (CAS 147657-22-5) is a synthetic analog of vitamin D3 designed to modulate keratinocyte activity It acts by binding to the vitamin D receptor leading to inhibition of keratinocyte proliferation and induction of their physiological differentiation These effects collectively reduce abnormal epidermal growth and the formation of scaling plaques Calcipotriol monohydrate is widely utilized in biomedical research to investigate the regulation of epidermal differentiation vitamin D receptor-mediated signaling and the pathophysiology of disorders such as psoriasis
Apexbio Technology LLC Amrinone 60719-84-8 250mg
Amrinone (CAS 60719-84-8) is a small molecule inhibitor of type 3 phosphodiesterase (PDE3) enzymes By blocking PDE3 activity amrinone increases intracellular cyclic adenosine monophosphate (cAMP) levels leading to enhanced cardiac contractility and vasodilation This mechanism has made amrinone a valuable tool for investigating cardiac function and vascular smooth muscle regulation in preclinical models It is frequently utilized in research focused on the pathophysiology and treatment of congestive heart failure as well as studies exploring intracellular signaling pathways involving cAMP
Medchemexpress LLC Tolclofos-methyl | 57018-04-9 | 98.6% | 250 MG
Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is utilized as a seed treatment to provide protection against soil-borne and seed-borne fungal pathogens that lead to seed decay and seedling blights.
- Broad-spectrum aromatic hydrocarbon fungicide
- Utilized as a seed treatment
- Provides protection against soil-borne and seed-borne fungal pathogens
- Prevents seed decay and seedling blights
- Intended for research use only
Medchemexpress LLC Chlorfenapyr | 122453-73-0 | MFCD01631152 | 99.4% | 250 MG
Chlorfenapyr is a pyrrole insecticide that acts as a pro-insecticide. Its mode of action involves mixed-function oxidase oxidizing and removing the Nethoxymethyl group to form the active metabolite, CL 303268. This active metabolite uncouples oxidative phosphorylation in the mitochondria, disrupting ATP production and leading to cell dysfunction and organism death.
- Pyrrole insecticide
- Used for termite control
- Used for crop protection against various insect and mite pests
- Low mammalian toxicity
Apexbio Technology LLC cis-Epoxysuccinic acid 16533-72-5 500mg
cis-Epoxysuccinic acid (CAS 16533-72-5) is an epoxysuccinic acid derivative that functions as an agonist of the succinate receptor SUCNR1 (GPR91) Activation of SUCNR1 by cis-Epoxysuccinic acid leads to a marked decrease in intracellular cyclic AMP (cAMP) concentrations with an EC50 of approximately 2 7 M This modulation of cAMP signaling may impact various cellular processes including metabolic regulation and inflammatory responses cis-Epoxysuccinic acid serves as a useful tool compound for investigating SUCNR1-mediated pathways and cAMP-associated signaling in cellular and molecular research
Apexbio Technology LLC Puromycin aminonucleoside(Synonyms: Puromycin Aminonucleoside, Puromycin Nucleoside, 3'-Amino-3'-deoxyadenosine, PAN, NSC 3056, Puromycin Aminonucleosid, Adenosine, 3'-amino-3'-deoxy-), 250mg, CAS: 58-60-6.
Puromycin aminonucleoside (CAS 58-60-6) is the aminonucleoside moiety derived from the antibiotic puromycin It induces nephrotic injury in experimental animal models leading to significant proteinuria and structural alterations in renal glomeruli In vitro treatment with puromycin aminonucleoside alters podocyte morphology characterized by reductions in cellular microvilli and disruption of foot-process structures In vivo administration in rats induces glomerular lesions resembling focal segmental glomerulosclerosis (FSGS) and lipid accumulation in mesangial cells This compound serves primarily as an investigative tool in elucidating mechanisms underlying nephrotic syndrome
Medchemexpress LLC Pyrimidin-4-ylmethanamine | 45588-79-2 | MFCD06796202 | 99.3% | 109.13 g·mol⁻¹ | C5H7N3 | 100 MG
4-Pyrimidine methanamine (pyrimidin-4-ylmethanamine) is a small-molecule synthetic intermediate used in medicinal chemistry and pharmaceutical synthesis. It features a pyrimidine core with a primary aminomethyl substituent at the 4-position, enabling further derivatization in lead optimization and building-block chemistry.
- High purity for reliable synthesis (Purity (NMR): 99.28%).
- Molecular formula C5H7N3 and molecular weight 109.13 g·mol⁻¹.
- Available in multiple package sizes, including 100 mg to 5 g.
- Suitable as a building block for drug development and synthetic intermediates.
Apexbio Technology LLC Camptothecin(Synonyms: CPT, Camptothecine, (+)-Camptothecin, NSC-94600, (S)-(+)-Camptothecin, Topotecin, 20(S)-Camptothecin), 250mg, CAS: 2114454.
Camptothecin (CAS 7689-03-4) is a small molecule inhibitor that selectively targets topoisomerase I exhibiting an IC50 value of 679 nM It causes DNA damage evident by phosphorylation of histone H2AX ( H2AX) leading to tumor cell death and cellular senescence via the ATM-Chk2-p53-p21 signaling pathway Additionally camptothecin induces autophagy through activation of the AMPK-TSC2-mTOR pathway Preclinical studies demonstrate its anti-tumor activity against tumor cell lines such as SMMC-7721 MCF-7 HCT-116 and NSCLC xenografts underscoring its utility in cancer biology research
Medchemexpress LLC Butanoic acid, 2-hydroxy-, (2R)- | 20016-85-7 | 99.9% | 104.10 | 250 MG
(R)-2-Hydroxybutanoic acid is an isomer of 2-Hydroxybutyric acid and can serve as an experimental control. This compound is a byproduct of insulin resistance, which can lead to impaired insulin signaling and mitochondrial overload. It enhances the viability of BRL3A, AML12, and primary mouse hepatocytes, and reduces AP-induced cytotoxicity.
- Isomer of 2-hydroxybutyric acid
- Can be used as an experimental control
- Enhances cell viability and reduces cytotoxicity in certain cell lines
- Appearance: solid (<50°C), liquid (>54°C)
- Color: colorless to off-white
Apexbio Technology LLC HLCL-61 1158279-20-9 100mg
HLCL-61 (CAS 1158279-20-9) is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5) an enzyme implicated in the epigenetic regulation of gene expression through symmetric dimethylation of arginine residues on histones and other proteins HLCL-61 shows specificity for PRMT5 exhibiting no inhibitory activity against PRMT1 PRMT4 or other type II PRMT family members In cellular studies HLCL-61 suppresses symmetric dimethylation of histones H3 and H4 leading to reduced viability and enhanced differentiation of acute myeloid leukemia (AML) cell lines and primary blasts HLCL-61 is currently utilized in preclinical research to investigate PRMT5-mediated epigenetic mechanisms in cancer
Apexbio Technology LLC HLCL-61 1158279-20-9 5mg
HLCL-61 (CAS 1158279-20-9) is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5) an enzyme implicated in the epigenetic regulation of gene expression through symmetric dimethylation of arginine residues on histones and other proteins HLCL-61 shows specificity for PRMT5 exhibiting no inhibitory activity against PRMT1 PRMT4 or other type II PRMT family members In cellular studies HLCL-61 suppresses symmetric dimethylation of histones H3 and H4 leading to reduced viability and enhanced differentiation of acute myeloid leukemia (AML) cell lines and primary blasts HLCL-61 is currently utilized in preclinical research to investigate PRMT5-mediated epigenetic mechanisms in cancer