Pyrroles
Cayman Chemical 4-hydroxy Atorvastatin lacton
A metabolite of atorvastatin; formed by metabolism of atorvastatin by CYP3A4
Medchemexpress LLC HY-111754 5mg Medchemexpress, DMX-5804 CAS:2306178-56-1 Purity:>98%
Medchemexpress, HY-111754 5mg DMX-5804 CAS:2306178-56-1 DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC 50 of 3 nM, a pIC 50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 ( pIC 50 , 8.18), and TNIK/MAP4K7 ( pIC 50 , 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-112706 5mg Medchemexpress, PF-06747711 CAS:1892576-58-7 Purity:>98%
Medchemexpress, HY-112706 5mg PF-06747711 CAS:1892576-58-7 PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 ( RORC2 , also known as RORγt ) inverse agonist, with an IC 50 of 4.1 nM. Anti-skin inflammatory activity [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC EX229, a benzimidazole derivative | 1219739-36-2 | MFCD31696597 | 99.4% | 431.87 | C24H18ClN3O3 | 5 MG
EX229 is a benzimidazole-derived small-molecule allosteric activator of AMP-activated protein kinase (AMPK) used for biochemical and cellular research. It binds AMPK complexes with submicromolar affinity and shows potent cellular activity, suitable for pathway and metabolic studies.
- Potent allosteric activator of AMPK (Kd ≈ 0.06 μM for primary complexes).
- Demonstrated cellular activity (EC50 ≈ 3 nM in Sf21 cell assay).
- High purity (≈99.4%).
- Soluble in DMSO (~13 mg/mL) with recommended in vivo formulation protocols.
- Stable as powder and in solvent when stored under recommended conditions.
- Available in small-mass packs and DMSO solutions for screening workflows.
eMolecules 7152-42-3 | 10-Phenyl-10H-phenothiazine | ChemScene | MFCD00156238 | 275.370 | C18H13NS | 97.000 | S1c2ccccc2N(c2ccccc2)c2ccccc12 | 100mg | 844787862
10-Phenyl-10H-phenothiazine | ChemScene | 7152-42-3 | MFCD00156238 | 275.370 | C18H13NS | 97.000 | S1c2ccccc2N(c2ccccc2)c2ccccc12 | 100mg | 844787862
Medchemexpress LLC Hlcl-61 hydrochloride | 1158279-20-9 | 99.9% | 380.91 | C23H25ClN2O | 5 MG
HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) used for research to probe PRMT5-mediated methylation and cellular responses. It reduces cell growth in a dose-dependent manner across multiple leukemia cell lines and inhibits symmetric arginine dimethylation of histones H3 and H4, supporting studies of epigenetic regulation and oncology research.
- Targets PRMT5 to inhibit arginine methylation.
- Reduces cell proliferation in leukemia cell lines; IC50s reported by manufacturer.
- High purity suitable for research applications.
- Soluble in DMSO (50 mg/mL); insoluble in water.
- Solid, white to off-white appearance; store sealed away from moisture under recommended conditions.
Apexbio Technology LLC Sunitinib 557795-19-4 1g
Sunitinib (CAS 557795-19-4) is an orally bioavailable small molecule inhibitor targeting multiple receptor tyrosine kinases (RTKs) including VEGFR1-3 PDGFR / c-kit and RET Research has shown sunitinib inhibits proliferation in nasopharyngeal carcinoma (NPC) cell lines HK1 CNE-1 CNE-2 HONE-1 and C666-1 with IC50 values ranging from approximately 2 06 to 7 57 M Additionally it induces apoptosis and G0/G1 cell cycle arrest in NPC cell lines and significantly decreases microvessel density in CNE-2 xenograft tumor models in vivo Thus sunitinib is useful for investigating pathways involved in tumor angiogenesis and proliferation
Apexbio Technology LLC Atorvastatin Calcium 134523-03-8 50mg
Atorvastatin Calcium (CAS 134523-03-8) is a selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme involved in cholesterol biosynthesis By targeting this enzyme atorvastatin reduces intracellular cholesterol production thereby stimulating hepatic expression of low-density lipoprotein (LDL) receptors and facilitating plasma LDL clearance Atorvastatin exhibits an IC50 of approximately 154 nM against HMG-CoA reductase Clinically atorvastatin decreases total cholesterol and LDL levels applicable to research models of hypercholesterolemia and cardiovascular disease including studies on lipid metabolism and atherosclerosis pathogenesis