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Filtered Search Results
Medchemexpress LLC Teneligliptin (hydrobromide hydrate) | 1572583-29-9 | >99.9% | 426.58 | 100 MG
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Teneligliptin (hydrobromide hydrate) | 1572583-29-9 | >99.9% | 426.58 | 100 MG
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eMolecules Medchem Express / A66 / 5mg / 446262599 / HY-13261 / / 1166227-08-2 / MFCD22378485 / 393.520 / C17H23N5O2S2
Medchem Express / A66 / 5mg / 446262599 / HY-13261 / / 1166227-08-2 / MFCD22378485 / 393.520 / C17H23N5O2S2
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Medchemexpress LLC HY-107456 10mg Medchemexpress, E6130 CAS:1427058-33-0 Purity:>98%
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Medchemexpress, HY-107456 10mg E6130 CAS:1427058-33-0 E6130 is an orally available and highly selective CX3CR1 modulator, that may be effective for treatment of inflammatory bowel disease. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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![Medchemexpress LLC N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | 945755-56-6 | MFCD24386874 | 99.7% | 444.53 | C25H28N6O2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502081508.png-250.jpg)
Medchemexpress LLC N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | 945755-56-6 | MFCD24386874 | 99.7% | 444.53 | C25H28N6O2 | 5 MG
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XL019 is a potent, orally bioavailable, selective inhibitor of Janus kinase 2 (JAK2) with low-nanomolar enzymatic potency and demonstrated cellular activity against JAK2-driven signaling.
- Potent JAK2 inhibition (IC50 ≈ 2.2 nM) with weaker activity against JAK1 and JAK3.
- Inhibits STAT3 and STAT5 phosphorylation in cells expressing mutant or wild-type JAK2.
- High chemical purity (≈99.7%) suitable for research applications.
- Molecular weight 444.53 and formula C25H28N6O2.
- Soluble in DMSO (≈25 mg/mL); use fresh DMSO and ultrasonic assistance if needed.
- Solid, light yellow to green yellow appearance; supplied as a 5 mg quantity.
- Recommended storage: powder -20°C for long-term; in solution -80°C.
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Medchemexpress LLC Protac FKBP degrader-3 | 2079056-43-0 | 99.5% | 1295.54 g/mol | C68H90N6O17S | 5 MG
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PROTAC FKBP Degrader-3 is a targeted protein degrader designed to recruit the VHL E3 ligase to FKBP proteins, promoting polyubiquitination and proteasomal degradation. It is supplied as a solid, off-white to light-yellow research reagent characterized for in vitro activity and formulated for biochemical and cell-based experiments. Typical handling includes storage at -20°C under nitrogen and dissolution in DMSO for assays.
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Medchemexpress LLC Protac Bcl2 degrader-1 | 2378801-85-3 | 99.8% | 941.84 g/mol | C45H45BrN6O10S | 10MG
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PROTAC Bcl2 degrader-1 is a cereblon-based proteolysis targeting chimera designed to selectively induce degradation of Bcl-2 and to show activity against Mcl-1. It is intended for biochemical and cellular research, supplied as a light yellow to yellow solid with high chemical purity and characterized potency in degradation assays.
- Induces degradation of Bcl-2 and shows activity against Mcl-1.
- Reported Bcl-2 IC50 4.94 μM and DC50 3.0 μM.
- High chemical purity of 99.8%.
- Molecular weight approximately 941.8 g/mol.
- Supplied as a light yellow to yellow solid for research use.
- Recommended storage at -20°C under inert gas; solvent stability and handling details available in technical documents.
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Medchemexpress LLC PMX 205 Trifluoroacetate | 99.5% | 953.06 | 10 MG
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PMX 205 Trifluoroacetate | 99.5% | 953.06 | 10 MG
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Medchemexpress LLC Terlipressin diacetate | 1884420-36-3 | 99.8% | 1347.48 | C56H82N16O19S2 | 100MG
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Terlipressin diacetate is a vasopressin analogue and a selective vasopressin V1 receptor agonist used in research to reduce splanchnic blood flow and portal pressure. It is applied in studies of acute variceal bleeding, hepatorenal syndrome, and norepinephrine-resistant septic shock, and shows anti-inflammatory and anti-oxidative effects. Supplied as a purified peptide with recommended frozen storage to preserve stability.
- High purity suitable for research applications.
- Selective vasopressin V1 receptor agonist activity.
- Relevant for models of portal hypertension and variceal bleeding.
- Exhibits anti-inflammatory and anti-oxidative properties.
- Storage recommendations minimize degradation and extend shelf life.
- Available in multiple pack sizes for flexible experimental needs.
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Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 50 MG
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WSB1 Degrader 1 is a potent and orally active degrader of WSB1 (WD repeat and SOCS box-containing 1). It exhibits anticancer metastatic effects. In vitro studies show it induces WSB1 degradation in H1299-WSB1 cells in a time-dependent and dose-dependent manner. It also demonstrates potent antimigration efficacy in KHOS and H460 cell lines. In vivo, daily oral treatment effectively inhibited pulmonary metastasis in Balb/c (nu/nu) mice bearing highly metastatic 4T1 breast cancer cells.
- Induces WSB1 degradation in H1299-WSB1 cells
- Exhibits potent antimigration efficacy in KHOS and H460 cell lines
- Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells
- Elevates RhoGDI2 protein levels in KHOS cells under hypoxia
- Blocks the wound-healing capability of wild-type A2780 cells
- Effectively inhibits pulmonary metastasis of cancer cells in animal models
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Medchemexpress LLC HY-112377 10mg Medchemexpress, MZP-55 CAS:2010159-48-3 Purity:>98%
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Medchemexpress, HY-112377 10mg MZP-55 CAS:2010159-48-3 MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC PROTAC BET degrader- 10mg | 3031993-61-7 | 10 MG
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PROTAC BET degrader-3 is a bifunctional proteolysis targeting chimera that recruits the von Hippel-Lindau (VHL) E3 ligase to BET-family bromodomains to induce targeted degradation of BET proteins. It is supplied as a research-grade powder for preclinical studies.
- Targets BET proteins via VHL-mediated degradation.
- Molecular formula C53H64N12O9S.
- Molecular weight 1045.22 g·mol⁻¹.
- Purity 99.11% (HPLC).
- Powder form; store at -20°C, shelf life 3 years.
- For research use only; not for human or clinical use.
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Medchemexpress LLC (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride | 2376990-26-8 | 96.33% | 632.64 | 100 MG
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(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology. It is for research use only and not sold to patients.
- Contains two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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![Enzo Life Sciences ET A receptor antagonist [BQ-610] (1mg). CAS: 141595-53-1](https://assets.fishersci.com/TFS-Assets/CCG/product-images/ENZOLOGO.png-250.jpg)
Enzo Life Sciences ET A receptor antagonist [BQ-610] (1mg). CAS: 141595-53-1
30-fold more potent ETA antagonist than BQ-123 in pig aortic smooth muscle membrane assay, same activity as BQ-123 when tested on pig cerebellum membrane. Formula: C36H44N6O6. MW: 656.8. Long Term Storage: -20°C.
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Selleck Chemical LLC Rapastinel
Rapastinel (GLYX-13 BV-102 TPPT-amide) is a partial agonist of N-methyl-D-aspartate receptor (NMDAR) that targeting a glycine site Rapastinel has long-lasting antidepressant effects
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eMolecules Medchem Express / Grazoprevir / 5mg / 446265386 / HY-15298 / / 1350514-68-9 / MFCD25976700 / 766.910 / C38H50N6O9S
Medchem Express / Grazoprevir / 5mg / 446265386 / HY-15298 / / 1350514-68-9 / MFCD25976700 / 766.910 / C38H50N6O9S
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