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Filtered Search Results
Medchemexpress LLC Doxorubicin-SMCC 25mg | 400647-59-8 | 762.76 | C39H42N2O14 | 25 MG
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Doxorubicin-SMCC is a drug-linker conjugate for antibody-drug conjugate (ADC) research that couples the anthracycline topoisomerase II inhibitor doxorubicin to a non-cleavable SMCC linker, producing a stable payload for bioconjugation and preclinical studies.
- Non-cleavable SMCC linker for stable conjugation.
- Acts as a DNA topoisomerase II inhibitor payload.
- Purity 98.8% and molecular weight 762.76.
- Orange to red solid physical form.
- Soluble in DMSO (125 mg/mL); ultrasonic recommended.
- CAS number 400647-59-8 for cross-referencing.
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Medchemexpress LLC Bisindolylmaleimide V | 113963-68-1 | 97.8% | 341.36 | 1 G
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Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 μM. It blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 μM. This product is for research use only and not sold to patients.
- Cell-permeable negative control for protein kinase C inhibition studies.
- Blocks activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo.
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Medchemexpress LLC Bisindolylmaleimide V | 113963-68-1 | 97.75% | 341.36 | 500 MG
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Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies, with an IC50 value exceeding 100 μM. It also blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo, with an IC50 of 8 μM. This product is intended for research use only and is not sold to patients.
- Cell-permeable negative control for protein kinase C inhibition studies.
- Blocks activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo.
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Medchemexpress LLC MIRA-1 | 72835-26-8 | 99.8% | 183.16 | 50 MG
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MIRA-1 is a maleimide analogue that can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. It exhibits anticancer activity.
- Induces apoptosis in mutant p53 cells.
- Restores p53-dependent transcriptional transactivation.
- Possesses anticancer activity.
- Suppresses the growth of Saos-2-His273 cells expressing mutant p53.
- Inhibits cell growth in a mutant p53-dependent manner.
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AdipoGen Bisindolylmaleimide V
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Chemical. CAS 113963-68-1. Formula C21H15N3O2. MW 341.4. Negative control for protein kinase C PKC inhibitors. S6K inhibitor. Necrosis inhibitor.
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eMolecules Medchem Express / RI-1 / 5mg / 446265442 / HY-15317 / / 415713-60-9 / MFCD00814248 / 361.600 / C14H11Cl3N2O3
Medchem Express / RI-1 / 5mg / 446265442 / HY-15317 / / 415713-60-9 / MFCD00814248 / 361.600 / C14H11Cl3N2O3
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Medchemexpress LLC Maleimidocaproyl monomethylauristatin F | 863971-19-1 | MFCD25976741 | >99.0% | 925.2 g/mol | C49H76N6O11 | 50 MG
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McMMAF (maleimidocaproyl monomethylauristatin F) is a maleimidocaproyl-protected derivative of monomethylauristatin F used as a cytotoxic payload and linker reagent in antibody-drug conjugate (ADC) development. It contains a thiol-reactive maleimide for conjugation to antibodies and delivers a potent tubulin polymerization inhibitor to target cells.
- Maleimidocaproyl-conjugated monomethylauristatin F for ADC applications.
- Thiol-reactive maleimide enables site-selective antibody conjugation.
- Potent tubulin inhibitor payload for targeted cytotoxicity.
- High purity suitable for research use; soluble in DMSO.
- Store at -20°C to maintain stability.
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Medchemexpress LLC HY-12012 5mg Medchemexpress, SB 216763 CAS:280744-09-4 Purity:>98%
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Medchemexpress, HY-12012 5mg SB 216763 CAS:280744-09-4 SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC50s of 34.3 nM for both GSK-3α and GSK-3β. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Advanced Chemblocks Inc 1-(2-AMINOETHYL)-2,5-DIHYDR 1G
1-(2-AMINOETHYL)-2,5-DIHYDRO-1H-PYRROLE-2,5-DIONE HYDROCHLORIDE
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Medchemexpress LLC 6-maleimidohexanoic acid N-hydroxysuccinimide ester | 55750-63-5 | >98.0% | 308.29 g/mol | C14H16N2O6 | 10 G
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6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent that couples amine-containing molecules to sulfhydryl groups via an NHS ester and a maleimide. It is used for hapten-carrier conjugation, enzyme immunoconjugates, and antibody-drug conjugate linker chemistry. For research use only.
- Reactive groups: maleimide for sulfhydryl coupling, NHS ester for amine coupling.
- High purity suitable for bioconjugation (≥98.0% by HPLC).
- Molecular weight 308.29 g/mol; formula C14H16N2O6.
- Available in laboratory pack sizes including 10 g.
- Intended for research use only; not for human or clinical use.
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Cayman Chemical BIsIndolylmaleImIde I 25mg
A highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM); competitive inhibitor for the ATP binding site of PKC; highly selective for PKCα, β1, β2, γ, δ, and ε isozymes; inhibits GSK3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM); competitively antagonizes the 5-HT3 receptor with a Ki value of 61 nM
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Medchemexpress LLC Crocin II | 55750-84-0 | MFCD11111454 | 98.0% | 10 MG
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Crocin II is a natural glycoside isolated from Gardenia jasminoides, supplied as a solid research reagent and analytical standard with reported antioxidant, anticancer, and antidepressant activities. The product is characterized by a molecular weight of 814.82 g/mol, CAS number 55750-84-0, and a recorded purity around 98%. Recommended storage is -20°C and protect from light; solubility in DMSO is approximately 25 mg/mL.
- Natural glycoside isolated from Gardenia jasminoides
- High purity suitable for analytical applications
- Molecular weight 814.82 g/mol and CAS 55750-84-0
- Soluble in DMSO (≈25 mg/mL) for in vitro use
- Storage recommended at -20°C and protect from light
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Medchemexpress LLC Amino-PEG4-Val-Cit-PAB-MMAE | 1492056-71-9 | 99.9% | 1370.71 g/mol | C69H115N11O17 | 25 MG
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Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable 4-unit polyethylene glycol (PEG) linker containing a valine-citrulline (Val-Cit) dipeptide and a para-aminobenzyl (PAB) self-immolative spacer designed for use in antibody-drug conjugate (ADC) synthesis. It provides a hydrophilic spacer, a protease-cleavable linker for controlled payload release, and an amine handle for conjugation to payloads such as MMAE. Supplied as a purified solid for research use and soluble in DMSO.
- Cleavable Val-Cit dipeptide enables protease-mediated payload release.
- PAB self-immolative spacer enables rapid payload release after cleavage.
- Four-unit PEG spacer increases hydrophilicity and solubility.
- Primary amine handle supports site-specific conjugation chemistries.
- High purity and characterized molecular weight for reproducible conjugation.
- Soluble in DMSO at 100 mg/mL for convenient stock preparation.
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Medchemexpress LLC N- t-Boc-Aminooxy-PE | 25MG
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N- t-Boc-Aminooxy-PE | 25MG
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Medchemexpress LLC Boc-aminooxy-PEG2-pr | 50MG
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Boc-aminooxy-PEG2-pr | 50MG
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