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Filtered Search Results
Medchemexpress LLC S R S -AHPC-amido-C | 50MG
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S R S -AHPC-amido-C | 50MG
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Medchemexpress LLC Glecaprevir | 1365970-03-1 | 838.87 | 100 MG
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Glecaprevir is a novel HCV NS3/4A protease inhibitor and a SARS-CoV 3CLpro inhibitor. It is intended for use as a laboratory chemical and for the manufacture of substances, exclusively for research purposes and by experienced personnel.
- HCV NS3/4A protease inhibitor
- SARS-CoV 3CLpro inhibitor
- IC50 values ranging from 3.5 to 11.3 nM (HCV NS3/4A protease)
- IC50 of 4.09 μM (SARS-CoV 3CLpro)
- For research use only
- Intended for experienced personnel
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Medchemexpress LLC HY-10900 10mg Medchemexpress, TCS 1102 CAS:916141-36-1 Purity:>98%
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Medchemexpress, HY-10900 10mg TCS 1102 CAS:916141-36-1 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-101763A 1g Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98%
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Medchemexpress, HY-101763A 1g (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 (S,R,S)-AHPC hydrochloride (MDK7526 hydrochloride) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC 50 of 1.11 μM in Ba/F3 cells [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC BAY-298 | 2471978-97-7 | 99.9% | 50 MG
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BAY-298 is an orally active and selective antagonist of the luteinizing hormone receptor (LH-R). It exhibits IC50 values of 96 nM for human LH (hLH), 23 nM for rat LH (rLH), and 78 nM for cynomolgus monkey LH (cLH). This compound has demonstrated the ability to reduce sex hormone levels and is intended for research use only.
- Orally active and selective LH-R antagonist
- Inhibits human, rat, and cynomolgus monkey LH-R
- Reduces sex hormone levels
- For research use only
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Medchemexpress LLC PROTAC CDK2/9 Degrader-1 | 2408641-24-5 | 99.9% | 50 MG
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PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). It suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. This compound is a PROTAC that functions by tethering a CDK inhibitor with a Cereblon ligand.
- Potent dual degrader for CDK2 and CDK9
- Suppresses prostate cancer PC-3 cell proliferation
- Functions by tethering a CDK inhibitor with a Cereblon ligand
- Induces cell cycle blockage at the G2/M phase
- Down-regulates Mcl-1 protein level
- Effectively degrades CDK2/9 in various cell lines
- Inhibits both CDK2 and CDK9
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Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.5% | 1107.26 | 50 MG
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Pasireotide acetate is a long-acting cyclohexapeptide somatostatin analogue that improves agonist activity at somatostatin receptors. It can suppress GH, IGF-I, and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. This compound also exhibits antisecretory, antiproliferative, and proapoptotic activity.
- Improves agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively).
- Suppresses GH, IGF-I, and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease.
- Exhibits antisecretory, antiproliferative, and proapoptotic activity.
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Medchemexpress LLC Protac SGK3 degrader-1 | 2381320-35-8 | 99.9% | 1157.38 g/mol | C57H73FN10O11S2 | 1MG
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PROTAC SGK3 degrader-1 is a VHL-ligand-based PROTAC chemical probe developed to induce proteasomal degradation of SGK3 in cellular systems. It exhibits rapid, concentration-dependent activity and is supplied as a high-purity research reagent.
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Medchemexpress LLC Cgp-42112 (Cgp-42112A) | 127060-75-7 | MFCD00133611 | 99.8% | 1052.19 g·mol-1 | C52H69N13O11 | 1MG
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CGP-42112 (CGP-42112A) is a peptide-like research compound that acts as a potent angiotensin II subtype 2 (AT2) receptor agonist. It is supplied for research use only and is available as solid material and as a DMSO solution. The product has a defined purity, molecular weight, solubility profile, and recommended storage conditions, making it suitable for in vitro assays and for formulation in common in vivo vehicles.
- Potent angiotensin II subtype 2 receptor agonist.
- High purity (99.84%).
- Molecular weight 1052.19 g·mol-1.
- Soluble in DMSO (100 mg/mL); compatible with common in vivo vehicles.
- Supplied as solid and as DMSO solution in multiple pack sizes.
- Powder stable at -20 °C for long-term storage; solutions stable at -80 °C.
- For research use only.
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Medchemexpress LLC Protac IDO1 degrader-1 | 2488851-89-2 | 99.0% | C40H53BrFN9O13 | 10MG
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PROTAC IDO1 Degrader-1 is a bifunctional small molecule designed to induce selective degradation of indoleamine 2,3-dioxygenase 1 (IDO1) by recruiting Cereblon E3 ligase, resulting in ubiquitination and proteasome-mediated clearance. It is intended as a research reagent for in vitro and biochemical studies probing IDO1 function and degradation mechanisms.
- induces targeted degradation of IDO1 via the ubiquitin-proteasome system.
- employs cereblon E3 ligase recruitment for selective target engagement.
- enables functional studies of IDO1 biology and pathway modulation.
- supplied as a characterized small-molecule research reagent for laboratory use.
- provided with reported molecular formula and purity for assay planning.
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Innovative Research Inc Ms PAI1 Rcmb WT Act 500ug
Mouse PAI-1 Recombinant Wild Type Active 500 ug - Mouse PAI-1 Recombinant Wild Type Active from Innovative Research has been recombinantly produced in E. coli and purified by affinity chromatography. This is a Frozen liquid buffered in 0.05M Sodium Acetate; 0.4M NaCl; 1mM EDTA; pH 5.0 and a purity of >95% as determined by SDS-PAGE. More Details Species Mouse Target PAI-1 Purification Method Affinity purified Purity 95% as determined by SDS-PAGE Source E. coli Storage Conditions -70 C Additional Information Active fraction contains between 30% and 70% active PAI-1. This product can be used as a control in applications like ELISA and Western Blot. It can be used for a wide range of in vitro applications, including fibrinolysis, hypertension studies, inhibition, plasminogen activation, protein-protein interactions, receptor binding, and more. For Research Use Only.
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Medchemexpress LLC Icatibant acetate | 138614-30-9 | 99.9% | 1364.57 g·mol⁻¹ | C61H93N19O15S | 5 MG
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Icatibant acetate is a synthetic peptide antagonist of the bradykinin B2 receptor used in pharmacology and signaling research. Supplied as the acetate salt, it is intended for in vitro and biochemical studies requiring a selective B2 antagonist.
- Potent bradykinin B2 receptor antagonist (IC50 1.07 nM; Ki 0.798 nM).
- Peptide sequence appropriate for receptor pharmacology studies.
- High purity (99.85%) suitable for sensitive assays.
- Molecular weight 1364.57 g·mol⁻¹ for accurate dosing.
- Available in multiple milligram sizes for dose-ranging experiments.
- Provided as an acetate salt to improve compound stability.
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Medchemexpress LLC Protac SGK3 degrader-1 | 2381320-35-8 | 99.9% | 1157.38 | C57H73FN10O11S2 | 10MG
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PROTAC SGK3 degrader-1 is a VHL-ligand-based proteolysis targeting chimera designed to induce degradation of Serum/Glucocorticoid Regulated Kinase 3 (SGK3) for biochemical and cell-based studies. The compound is supplied in small research pack sizes and is characterized by high analytical purity with supporting RP-HPLC documentation.
- VHL-ligand-based PROTAC design for targeted protein degradation.
- Efficient degradation of SGK3 in cell-based assays.
- High purity suitable for research applications.
- Available in small pack sizes for assay development.
- Supported by RP-HPLC analytical documentation.
- Validated for use in cell viability and western blot analyses.
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Medchemexpress LLC HY-102053 10mg Medchemexpress, Apimostinel CAS:1421866-48-9 Purity:>98%
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Medchemexpress, HY-102053 10mg Apimostinel CAS:1421866-48-9 Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-13261 5mg Medchemexpress, A66 CAS:1166227-08-2 Purity:>98%
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Medchemexpress, HY-13261 5mg A66 CAS:1166227-08-2 A66 is a highly specific and selective p110α inhibitor with an IC50 of 32 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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