Quinolines and derivatives
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Filtered Search Results
Medchemexpress LLC CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 5 MG
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CLIP (86-100) | 648881-58-7 | 98.5% | 1674.10 | 5 MG
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BIOHIPPO
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5000858816 HUMAN MEDI-578 BIOSIMILAR
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Ambeed AMBEED
5000869775 DBCO-AMINE 250MG
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TARGETMOL CHEMICALS INC Amorolfine hydrochloride 200MG
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Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine hydrochloride , a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes. Purity 100%
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Medchemexpress LLC Capivasertib | 1143532-39-1 | C21H25ClN6O2 | 200 MG
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Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor, effectively inhibiting Akt1, Akt2, and Akt3 with high selectivity. This compound demonstrates in vitro inhibition of cancer cell proliferation, leading to apoptosis and G1 cell cycle arrest. In vivo studies confirm its good oral bioavailability, favorable pharmacokinetic properties, and significant ability to inhibit tumor growth in various human xenograft models. It is currently undergoing clinical evaluation.
- Potent pan-AKT kinase inhibitor
- Highly selective for Akt over other kinases
- Inhibits proliferation in diverse cancer cell lines
- Induces apoptosis and G1 cell cycle arrest
- Exhibits good oral bioavailability
- Effectively inhibits tumor growth in xenograft models
- Inhibits P70S6K, PKA, and ROCK2 activity
- Suppresses phosphorylation of AKT substrates
- Induces FOXO3a nuclear translocation
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000430687 ACRIDINE ORANGE 10-N 10MM 1ML
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428337 SULFO-CY3 AMINE 25MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428408 COLLAGENASE IV CLOS 200MG
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Medchemexpress LLC 7-Bromoisoquinoline | 58794-09-5 | 99.98% | C9H6BrN | 1 G
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7-Bromoisoquinoline is a brominated isoquinoline and synthetic precursor. It is utilized to construct the isoquinoline functional group at the C17 position of target molecules, serving as a key synthetic intermediate for the synthesis of cortistatin A-derived anti-angiogenic steroidal analogs.
- Purity of 99.98%
- Appears as a solid, white to light brown
- Molecular formula: C9H6BrN
- Molecular weight: 208.06
- CAS number: 58794-09-5
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 100 mg/mL
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Apexbio Technology LLC CP 339818 hydrochloride 50mg
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CP 339818 hydrochloride (CAS 478341-55-8) is a small-molecule antagonist targeting the Kv1 3 potassium channel It is designed to selectively inhibit Kv1 3-mediated ion conductance thereby modulating T-cell activation CP 339818 hydrochloride exerts its biological activity primarily through stabilization of the Kv1 3 channel s C-type inactivation state In in vitro studies CP 339818 hydrochloride demonstrates potent inhibition of Kv1 3 channels with an IC50 value of approximately 200 nM Based on these pharmacological properties CP 339818 hydrochloride holds research potential in the investigation of immune modulation mechanisms relevant to autoimmune and inflammatory disorders
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Accela Chembio Inc Quinoline-5-carboxylic Acid | 1g | 7250-53-5 | MFCD00047608 | 95+% | Shelf Life: 1440 Days | Regular
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Quinoline-5-carboxylic Acid | 1g | 7250-53-5 | MFCD00047608 | 95+% | Shelf Life: 1440 Days | Regular
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TARGETMOL CHEMICALS INC Paroxetine hydrochloride 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Paroxetine hydrochloride (Paroxetine HCl) is a serotonin uptake inhibitor that is effective in the treatment of depression. Purity 99.91%
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Apexbio Technology LLC Oxymatrine 16837-52-8 200mg
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Oxymatrine (CAS 16837-52-8) is a quinolizidine alkaloid extracted from Sophora flavescens It has been shown to modulate multiple cellular pathways associated with fibrosis and neurodegeneration including inhibition of TGF- 1-mediated signaling and reduction of pro-inflammatory cytokine expression Oxymatrine exhibits antifibrotic and neuroprotective properties in various experimental models It is also extensively studied for its antiviral activity against hepatitis B virus and has been applied in traditional Chinese medicine for hepatitis management This compound is valuable for investigating mechanisms of fibrosis neuroprotection and viral pathogenesis
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Medchemexpress LLC 7,4'-Dihydroxyflavone | 2196-14-7 | 25 MG
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7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis. It functions as an eotaxin/CCL11 inhibitor and a CBR1 inhibitor with an IC50 of 0.28 μM. This compound suppresses eotaxin production and prevents dexamethasone (Dex)-paradoxical adverse effects. Furthermore, 7,4'-DHF inhibits MUC5AC gene expression, mucus production, and secretion by regulating NF-κB, STAT6, and HDAC2, decreasing PMA-stimulated MUC5AC expression in NCI-H292 human airway epithelial cells with an IC50 of 1.4 μM.
- Purity: 99.64%
- Molecular weight: 254.24
- Formula: C15H10O4
- CAS number: 2196-14-7
- Appearance: Solid, light yellow to yellow
- Structure classification: Flavonoids, Flavones, Phenols, Polyphenols
- Acts as eotaxin/CCL11 and CBR1 inhibitor (IC50: 0.28 μM)
- Inhibits MUC5AC gene expression and mucus production
- IC50: 1.4 μM (NCI-H292 human airway epithelial cell)
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eMolecules 1255942-06-3 | DBCO-amine | Ambeed | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 5g | 837384309
DBCO-amine | Ambeed | 1255942-06-3 | MFCD22380759 | 276.339 | C18H16N2O | 98.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 5g | 837384309
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