Quinolines and derivatives
eMolecules 16959-62-9 | methyl indolizine-2-carboxylate | Pharmablock | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 25mg | 788527012
methyl indolizine-2-carboxylate | Pharmablock | 16959-62-9 | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 25mg | 788527012
eMolecules 16959-62-9 | methyl indolizine-2-carboxylate | Pharmablock | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 50mg | 788527013
methyl indolizine-2-carboxylate | Pharmablock | 16959-62-9 | MFCD13178636 | 175.187 | C10H9NO2 | 97.000 | COC(=O)c1cc2ccccn2c1 | 50mg | 788527013
Medchemexpress LLC SRI 6409-94 | 127697-58-9 | 99.3% | 379.49 | 1 ML
SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. It serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.
- Causes virgin female outbred Syrian golden hamsters to produce deformed offspring in a dose-dependent manner.
- Leads to significant reductions in mean fetal body weight and in the numbers of ossified skeletal districts.
Medchemexpress LLC HSGN-94 | 2570797-85-0 | 98.8% | 508.51 | 1 ML
HSGN-94 is a potent antimicrobial agent that inhibits lipoteichoic acid (LTA) biosynthesis. It is effective against drug-resistant Gram-positive bacteria, including MRSA and Vancomycin-resistant Enterococci, also inhibiting their biofilm formation. It reduces pro-inflammatory cytokines and shows in vivo efficacy in an MRSA murine wound infection model.
- Potent antimicrobial agent targeting lipoteichoic acid (LTA) biosynthesis.
- Effective against drug-resistant Gram-positive bacteria (MIC values: 0.25-2 μg/mL).
- Inhibits biofilm formation in MRSA and Vancomycin-resistant Enterococci.
- Reduces pro-inflammatory cytokines.
- Demonstrates in vivo efficacy in a murine wound infection model.
- Directly binds to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (PgsA).
- Downregulates PgsA expression in *S. aureus*.
- Non-toxic to HaCat cells up to 64 μg/mL.
Medchemexpress LLC Lomitapide | 182431-12-5 | 99.6% | 693.72 | 200 MG
Lomitapide is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro. Intended for research use only, it undergoes hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4 and interacts with CYP3A4 substrates. It has been shown to reduce plasma concentrations of low-density lipoprotein cholesterol (LDL-C) by more than 50%.
- Target: microsomal triglyceride-transfer protein (MTP)
- IC50: 8 nM (MTP) in vitro
- Metabolism: hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4
- Bioavailability: 7.1% for the 50-mg capsule
- Half-life: 39.7 hours
- Appearance: white to off-white solid
- Powder storage: -20°C for 3 years, 4°C for 2 years
- Solvent storage: -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 200 MG
Apilimod is a potent IL-12/IL-23 inhibitor, strongly inhibiting IL-12 with IC50s of 1 nM and 2 nM in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It is also described as a potent and highly selective PIKfyve inhibitor.
- Potent IL-12/IL-23 inhibitor
- Strongly inhibits IL-12 with IC50s of 1 nM and 2 nM
- Potent and highly selective PIKfyve inhibitor
- Inhibits IFN-γ production in human PBMCs
- Reduces severity of experimental autoimmune uveoretinitis (EAU)
- Lowers level of IL-12 p40 in serum without altering body weight in EAU mice
- Effective in Th1 model, with 51%±8% inhibition
Medchemexpress LLC Fmf-06-098-1 | 2769753-07-1 | 98.8% | 1073.76 | 25 MG
FMF-06-098-1 is a multi-target kinase PROTAC degrader that targets degradation kinases such as AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1. The compound is composed of a target protein ligand, a VHL ligand, and a linker.
- Store powder at -20°C for 3 years, or 4°C for 2 years.
- Store in solvent at -80°C for 6 months, or -20°C for 1 month.
Medchemexpress LLC EGFR-IN-86 | 3055550-22-3 | 99.9% | 423.49 | 25 MG
EGFR-IN-86 is an EGFR inhibitor with an IC50 of 1.5 nM. It shows high activity against glioblastoma, inducing apoptosis and arresting U87 cell cycles in the G2/M phase. This product is for research use only and not sold to patients.
- Potent EGFR inhibitor
- High activity against glioblastoma
- Induces apoptosis
- Arrests U87 cell cycles in G2/M phase
Medchemexpress LLC Matrine | 519-02-8 | 98.0% | 248.37 | 200 MG
Matrine (Matridin-15-one) is an alkaloid found in plants of the *Sophora* genus. It acts as an agonist for kappa opioid receptor and u-receptor, and exhibits a range of pharmacological properties, including anti-cancer, anti-oxidative stress, anti-inflammatory, and anti-apoptosis effects. It holds potential for research into diseases such as human non-small cell lung cancer, hepatoma, papillary thyroid cancer, and acute kidney injury (AKI).
- Acts as a kappa opioid receptor and u-receptor agonist.
- Demonstrates anti-cancer effects.
- Possesses anti-oxidative stress properties.
- Exhibits anti-inflammatory effects.
- Has anti-apoptosis effects.
- Potential for research in human non-small cell lung cancer, hepatoma, papillary thyroid cancer, and acute kidney injury (AKI).
Medchemexpress LLC Oxymatrine | 16837-52-8 | 99.9% | 264.37 | 200 MG
Oxymatrine | 16837-52-8 | 99.9% | 264.37 | 200 MG
Medchemexpress LLC Cinchonidine (α-Quinidine) | 485-71-2 | 99.6% | 294.39 | 100 G
Cinchonidine (α-Quinidine) is a cinchona alkaloid found in *Cinchona officinalis* and *Gongronema latifolium*. It is a building block used in asymmetric synthesis in organic chemistry. It acts as a weak inhibitor of the serotonin transporter (SERT) and exhibits antimalarial activities.
- Derived from *Cinchona officinalis* and *Gongronema latifolium*
- Used as a building block in asymmetric synthesis
- Weak inhibitor of the serotonin transporter (SERT)
- Exhibits antimalarial activities
Medchemexpress LLC Paeoniflorin | 23180-57-6 | 98.9% | 480.46 | 200 MG
Paeoniflorin is a heat shock protein-inducing compound commonly found in plants of the Paeoniaceae family. It exhibits diverse biological activities, making it suitable for various research applications.
- Exhibits anticancer activity
- Has anti-inflammatory properties
- Enhances cognition and attenuates learning impairment
- Provides anti-oxidative stress benefits
- Prevents antiplatelet aggregation
- Expands blood vessels
- Reduces blood viscosity
