Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Propidium iodide(Synonyms: PI, Propidium iodide solution, PI staining reagent, Propidium iodide nuclear stain), 10mg, CAS: 25535-16-4.
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Propidium iodide (CAS 25535-16-4) commonly abbreviated as PI is a fluorescent nucleic acid intercalating dye widely employed in biomedical research Structurally analogous to ethidium bromide PI intercalates into double-stranded DNA molecules without sequence specificity binding approximately one dye per 4 5 base pairs Due to membrane impermeability PI selectively enters cells only when plasma membrane integrity is compromised as occurs during cell death or late apoptosis Upon DNA binding its fluorescence notably increases facilitating detection via fluorescence microscopy spectrometry or flow cytometry PI is routinely utilized for distinguishing necrotic or late apoptotic cells in viability assays apoptosis studies (often paired with Annexin V) and cell cycle analyses
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Apexbio Technology LLC Dihydroethidium(Synonyms: Hydroethidine, DHE, HE, Dihydroethidine, Ethidium hydride), 25mg, CAS: 104821-25-2.
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Dihydroethidium (CAS 104821-25-2) also known as hydroethidine is a cell-permeable fluorescent probe widely utilized for detecting superoxide anions (O ) in live cells After entering cells dihydroethidium is oxidized by intracellular superoxide anions to ethidium which subsequently intercalates into DNA emitting detectable red fluorescence (excitation/emission 518/605 nm) Unoxidized dihydroethidium exhibits blue fluorescence (355/420 nm) The intensity of the red fluorescence correlates directly with intracellular O concentration Thus dihydroethidium serves as a valuable tool in evaluating oxidative stress and studying associated physiological/pathological processes including apoptosis cell proliferation cardiovascular pathologies diabetes and cancer
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eMolecules 3-Aminoquinoline-2-carboxylic acid | 887245-74-1 | MFCD13189674 | 250mg
Ambeed | 3-Aminoquinoline-2-carboxylic acid | 250mg | 595927622 | A840863 | | 887245-74-1 | MFCD13189674 | 188.186 | C10H8N2O2
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eMolecules EMOLECULES INC
5000471645 TERT-BUTYL 4-AMINO-4-CARBAM 5G
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eMolecules Synthonix Methyl 2-(quinolin-6-yl)acetate 250mg 649427514 M38116 0 000 5622-36-6 MFCD04038669 201 225 C12H11NO2
Synthonix Methyl 2-(quinolin-6-yl)acetate 250mg 649427514 M38116 0 000 5622-36-6 MFCD04038669 201 225 C12H11NO2
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eMolecules 7-BROMOISOQUINOLINE 250MG
5000192112 7-BROMOISOQUINOLINE 250MG
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Medchemexpress LLC Al-611 | 2481279-61-0 | 99.9% | C25H33F2N6O8P | 10MG
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AL-611 is a research-grade small-molecule inhibitor described by the manufacturer as an HCV protease inhibitor intended for laboratory research use. It is supplied as a white to off-white solid and is characterized by a high reported purity and defined molecular properties.
- Potent HCV protease inhibitor for laboratory research.
- High purity (99.93%).
- White to off-white solid, suitable for analytical and biological assays.
- Molecular weight 614.54 Da; molecular formula C25H33F2N6O8P.
- Datasheet, certificate of analysis, and safety data sheet available.
- Intended for research use only, not for human or veterinary use.
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Apexbio Technology LLC Cyclosporin A 59865-13-3 200mg
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Cyclosporin A is an immunosuppressive agent acting primarily through inhibition of cyclophilins intracellular peptidyl-prolyl isomerases with a reported IC50 of 7 nM Cyclophilins regulate mitochondrial permeability transition pore (MPTP) opening intracellular calcium signaling and NFAT transcriptional activation pathways Cyclosporin A s ability to inhibit calcineurin-NFAT signaling in T-cell activation leads to suppression of inflammatory immune responses indicating potential use in autoimmune disorder research Additionally it modulates cell apoptosis and survival mechanisms in diverse models including retinal ischemic injury viral entry (HBV HCV) and tumor biology in colon cancer cell lines
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Sigma Aldrich Fine Chemicals Biosciences Dimidium bromide BioReagent, suitable for fluorescence, ~95% (AT) | 518-67-2 | MFCD00011757 | 250MG
Dimidium bromide BioReagent, suitable for fluorescence, ~95% (AT) | Purity: ~95% (AT) | Mol Wt: 380.28 | 518-67-2 | MFCD00011757 | 250MG
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eMolecules EMOLECULES INC
5000473587 7-BROMOQUINOLINE 100G
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eMolecules Broadpharm Fmoc-N-amido-PEG10-acid 250mg 724438043 BP-22279 98 000 2101563-45-3 MFCD28122954 751 867 C38H57NO14
Broadpharm Fmoc-N-amido-PEG10-acid 250mg 724438043 BP-22279 98 000 2101563-45-3 MFCD28122954 751 867 C38H57NO14
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Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 99.7% | 156.20 | 5g
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Methyl phenyl sulfone is a drug impurity
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eMolecules Ambeed / 8-Hydroxyquinoline-5-carbaldehyde / 100mg / 506389925 / A268393 / / 2598-30-3 / MFCD03425064 / 173.171 / C10H7NO2
Ambeed / 8-Hydroxyquinoline-5-carbaldehyde / 100mg / 506389925 / A268393 / / 2598-30-3 / MFCD03425064 / 173.171 / C10H7NO2
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Apexbio Technology LLC WAY-600 1062159-35-6 200mg
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WAY-600 is an ATP-competitive inhibitor targeting mammalian target of rapamycin (mTOR) specifically inhibiting the phosphorylation activity mediated by mTOR complexes It suppresses mTORC1 signaling via inhibition of phosphorylation of ribosomal S6 kinase (S6K) at Thr389 and attenuates mTORC2 signaling by inhibiting phosphorylation of protein kinase B (AKT) at Ser473 Importantly WAY-600 does not interfere with AKT phosphorylation at Thr308 The compound demonstrates marked selectivity for mTOR over phosphatidylinositol 3-kinase (PI3K) isoforms displaying greater than 100-fold selectivity against PI3K and over 500-fold selectivity against PI3K WAY-600 represents a valuable tool for investigating mTOR-dependent signaling pathways metabolism regulation cellular proliferation autophagy and related oncological and metabolic research areas
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Sigma Aldrich Fine Chemicals Biosciences Ethyl cinnamate 98 stabili1KG
REAGENT Ethyl cinnamate 98 stabili1KG
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