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Filtered Search Results
Medchemexpress LLC Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]- | 312636-16-1 | 99.25% | 302.78 | 200 MG
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SKI-II is an orally active and synthetic inhibitor of sphingosine kinase (SK) activity. It is intended for research use only and causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. It inhibits cell proliferation and promotes β-catenin degradation.
- Orally active and synthetic inhibitor of sphingosine kinase (SK) activity
- IC50 values: 78 μM for SK1 and 45 μM for SK2
- Causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation
- Inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway
- Promotes the degradation of β-catenin by enhancing Wnt5A
- Shows synergistic effect with DDP in human gastric carcinoma SGC7901/DDP cell line
- Reduces S1P concentrations in plasma in mice with chronic administration
- Reduces tumor growth in mice bearing solid tumor models
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Medchemexpress LLC Teniposide | 29767-20-2 | MFCD00866516 | 98.4% | 656.65 | 200 MG
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Teniposide is a podophyllotoxin derivative that functions as a topoisomerase II inhibitor and is used as a chemotherapeutic agent.
- Acts as a topoisomerase II inhibitor
- Functions as a chemotherapeutic agent
- Demonstrates antiproliferative activity against various human cancer cell lines, including A549, CWR22R, HeLa, HepG2, MCF7, PC-3, and RPMI 8402
- Induces apoptosis in Tca8113 cells
- Causes cell cycle arrest at the G2/M phase in Tca8113 cells
- Can be formulated into a clear solution for in vivo experiments using various protocols, including 10% DMSO, 40% PEG300, 5% Tween-80, and 45% Saline, or 10% DMSO and 90% Corn Oil
- Referenced in multiple publications
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Medchemexpress LLC Prostaglandin H2 | 42935-17-1 | ≥95.0% | 352.47 | 100 UG
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Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor that causes vasoconstriction. It is a common precursor of all prostaglandins, produced by cells expressing cyclooxygenases. PGH2 activates PGD2 receptors, induces eosinophil migration, inhibits platelet aggregation, and accelerates the formation of amyloid β1-42 oligomers. It is used in research for inflammation and neurological diseases, such as Alzheimer's disease.
- Increases forward-scatter of eosinophils.
- Induces shape changes and calcium production in eosinophils.
- Induces migration and collagen-induced platelet aggregation in eosinophils.
- Inhibits eosinophil degranulation by activating CRTH2 receptors.
- Accelerates the rate of formation of dimers and higher oligomers of amyloid β1-42.
- Induces contraction of rabbit pulmonary artery.
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eMolecules 1255942-06-3 | DBCO-AMINE | AstaTech | MFCD22380759 | 276.339 | C18H16N2O | 95.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 1g | 602855722
DBCO-AMINE | AstaTech | 1255942-06-3 | MFCD22380759 | 276.339 | C18H16N2O | 95.000 | NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 1g | 602855722
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eMolecules 5470-96-2 | 2-Quinolinecarboxaldehyde | AA Blocks LLC | MFCD00075032 | 157.172 | C10H7NO | 0.000 | O=Cc1ccc2ccccc2n1 | 5g | 538464160
2-Quinolinecarboxaldehyde | AA Blocks LLC | 5470-96-2 | MFCD00075032 | 157.172 | C10H7NO | 0.000 | O=Cc1ccc2ccccc2n1 | 5g | 538464160
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eMolecules 343926-69-2 | 4-bromopyrimidin-2-amine | Pharmablock | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 50g | 551064076
4-bromopyrimidin-2-amine | Pharmablock | 343926-69-2 | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 50g | 551064076
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eMolecules 59107-51-6 | 8-Chloronaphthalen-1-amine | AA Blocks LLC | MFCD00465087 | 177.630 | C10H8ClN | 0.000 | Nc1cccc2cccc(Cl)c12 | 25g | 761904658
8-Chloronaphthalen-1-amine | AA Blocks LLC | 59107-51-6 | MFCD00465087 | 177.630 | C10H8ClN | 0.000 | Nc1cccc2cccc(Cl)c12 | 25g | 761904658
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eMolecules EMOLECULES INC
NC4013180 5-AMINO-8-HYDROXYQUINOLINE
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eMolecules 4965-36-0 | 7-Bromoquinoline | Key Organics/BIONET | MFCD03695823 | 208.058 | C9H6BrN | 95.000 | Brc1ccc2cccnc2c1 | 5mg | 564169977
7-Bromoquinoline | Key Organics/BIONET | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 95.000 | Brc1ccc2cccnc2c1 | 5mg | 564169977
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Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.4% | 25 G
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Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It is a potent, orally active, selective cytochrome P450db inhibitor and a K+ channel blocker. It can induce apoptosis and is used for malaria research.
- Antiarrhythmic agent
- Potent, orally active, selective cytochrome P450db inhibitor
- K+ channel blocker with an IC50 of 19.9 μM
- Induces apoptosis
- Can be used for malaria research
- Shows cytotoxicity against MES-SA cells
- Shows effects on the PTZ-induced seizure threshold in vivo
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Medchemexpress LLC 8-Hydroxyquinoline hemisulfate | 134-31-6 | 99.9% | 194.20 | 1 ML
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8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.
- Functions as a monoprotic bidentate chelating agent.
- Exhibits antiseptic properties.
- Acts as a disinfectant.
- Possesses pesticide properties.
- Functions as a transcription inhibitor.
- For research use only.
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Medchemexpress LLC 7-Hydroxycarbostyril | 70500-72-0 | 99.1% | 161.16 | 10 G
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7-Hydroxycarbostyril (synonyms: 7-Hydroxyquinolinone; 2,7-Dihydroxyquinoline) is a quinolinone derivative. It can be used for the synthesis of Brexpiprazole, an orally active antipsychotic agent that acts as a partial agonist of human 5-HT1A and dopamine D2L receptors. This product is for research use only and not sold to patients.
- Quinolinone derivative
- Used for synthesis of Brexpiprazole
- Brexpiprazole acts as a partial agonist of human 5-HT1A and dopamine D2L receptors
- For research use only
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Medchemexpress LLC Cinchonidine (α-quinidine) | 485-71-2 | 99.6% | 294.39 | 1 G
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Cinchonidine (α-Quinidine) is a cinchona alkaloid found in *Cinchona officinalis* and *Gongronema latifolium*. It is used as a building block in asymmetric synthesis in organic chemistry. It is a weak inhibitor of the serotonin transporter (SERT) and exhibits antimalarial activities.
- Found in *Cinchona officinalis* and *Gongronema latifolium*.
- Used as a building block in asymmetric synthesis in organic chemistry.
- Weak inhibitor of serotonin transporter (SERT).
- Exhibits antimalarial activities.
- Physical appearance: Solid, White to off-white.
- Storage conditions: Room temperature for shipping; 4°C, protected from light, stored under nitrogen for storage.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000427441 BETULIN 200MG
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Medchemexpress LLC 1-Piperazineacetamide, N-(2,6-dimethylphenyl)- | 5294-61-1 | 99.8% | 247.34 | 200 MG
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CVT-2738 is an orally active metabolite of Ranolazine. It demonstrates a protective effect against Isoprenaline-induced myocardial ischemia in mice and is suitable for use in myocardial ischemia research.
- Orally active metabolite
- Demonstrates protective effect against myocardial ischemia
- Suitable for myocardial ischemia research
- Ships at room temperature
- Stable as powder for 3 years at -20°C
- Soluble in DMSO (10 mg/mL)
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