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Filtered Search Results
Medchemexpress LLC Glucocorticoid receptor modulator 1 | 2868357-11-1 | C24H23ClN2O4S | 200 MG
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Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator. It has an IC50 value of 9 nM for NF-κB and 130 nM for AP-1. This product can effectively reduce the expression of inflammatory factors such as IL-6, IL-1β, and TNF-α, and can also relieve dermatitis in mice.
- Highly potent and orally active.
- Non-steroidal selective glucocorticoid receptor modulator.
- Inhibits NF-κB and AP-1 pathways.
- Reduces the expression of inflammatory factors like IL-6, IL-1β, and TNF-α.
- Relieves dermatitis in mice.
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Medchemexpress LLC 1H-Imidazole-2-carbaldehyde | 10111-08-7 | 96.09 | 25 G
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1H-Imidazole-2-carbaldehyde is a biochemical reagent used in life science research. It functions as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor, with applications in suppressing type-2 diabetes. Additionally, it is utilized in the preparation of tridentate Schiff-base carboxylate-containing ligands and studies involving imidazole-directed allylation of aldimines.
- Biochemical reagent for life science research.
- Functions as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor.
- Applied to suppress type-2 diabetes.
- Used in the preparation of tridentate Schiff-base carboxylate-containing ligands.
- Involved in the study of imidazole-directed allylation of aldimines.
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Apexbio Technology LLC Oxymatrine 16837-52-8 200mg
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Oxymatrine (CAS 16837-52-8) is a quinolizidine alkaloid extracted from Sophora flavescens It has been shown to modulate multiple cellular pathways associated with fibrosis and neurodegeneration including inhibition of TGF- 1-mediated signaling and reduction of pro-inflammatory cytokine expression Oxymatrine exhibits antifibrotic and neuroprotective properties in various experimental models It is also extensively studied for its antiviral activity against hepatitis B virus and has been applied in traditional Chinese medicine for hepatitis management This compound is valuable for investigating mechanisms of fibrosis neuroprotection and viral pathogenesis
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Medchemexpress LLC Oxaliplatin | 61825-94-3 | 99.99% | 397.29 | 200 MG
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Oxaliplatin is an analytical standard and DNA synthesis inhibitor. It induces DNA crosslinking damage, preventing DNA replication and transcription, and ultimately leading to apoptosis. This product is intended for various research and analytical applications, particularly in cancer research.
- DNA synthesis inhibitor
- Causes DNA crosslinking damage
- Prevents DNA replication and transcription
- Induces apoptosis
- Suitable for cancer research
- Analytical standard grade for reference assays
- Used in qualitative, quantitative, and methodological research experiments
- Applicable in techniques such as HPLC, GC, and MS
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TARGETMOL CHEMICALS INC MORACIN C 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Moracin C a natural compound found in Morus mesozygia Morus alba var. multicaulis is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells. purity: 99%
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Apexbio Technology LLC Elesclomol (STA-4783) 488832-69-5 200mg
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Elesclomol (STA-4783 CAS 488832-69-5) is a small molecule identified through phenotype-based screens for apoptotic activity which induces apoptosis in cancer cells by elevating intracellular reactive oxygen species (ROS) Its primary cellular target is mitochondrial electron transport disruption of which results in rapid accumulation of oxidative stress exceeding adaptive thresholds and ultimately triggering apoptotic cell death Elesclomol demonstrates antitumor activity across diverse human tumor xenograft models and is currently studied as an investigational anticancer compound capable of extending progression-free survival
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Medchemexpress LLC Paliperidone (9-Hydroxyrisperidone) | 144598-75-4 | 99.4% | C23H27FN4O3 | 200 MG
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Paliperidone (9-Hydroxyrisperidone) is the major active metabolite of Risperidone, functioning as a dopamine D2 and 5-HT2A antagonist. It also exhibits antagonist activity at α1 and α2 adrenergic receptors and H1-histaminergic receptors, demonstrating efficacy as an antipsychotic agent against schizophrenia.
- Major active metabolite of risperidone
- Dopamine D2 antagonist
- 5-HT2A antagonist
- Antagonist at α1 and α2 adrenergic receptors
- Antagonist at H1-histaminergic receptors
- Effective antipsychotic agent against schizophrenia
- For research use only
- Increases caspase-3 activity in neuroblastoma cells
- May modulate Akt1/GSK3β pathway to protect SK-N-SH cells from glutamate damage
- Can protect SK-N-SH cells from apoptosis induced by glutamate
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Medchemexpress LLC AS1842856 | 836620-48-5 | MFCD30718173 | 99.9% | 347.38 g/mol | C18H22FN3O3 | 200 MG
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AS1842856 is a small-molecule Foxo1 inhibitor used in laboratory research to probe FOXO1-regulated pathways, including autophagy. The compound (CAS 836620-48-5) is cell-permeable, reported to have potent inhibitory activity (IC50 ≈ 30 nM), and is supplied with supporting analytical documentation for research use.
- Potent Foxo1 inhibitor activity (IC50 ≈ 30 nM).
- High reported purity suitable for analytical and biological experiments.
- Available as solid and as a DMSO solution for flexible formulation.
- Defined storage stability for powder and for solutions under controlled conditions.
- Includes datasheet, certificate of analysis, and safety data sheet for traceability and safe handling.
- Appropriate for in vitro studies of autophagy and FOXO1 signaling pathways.
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Medchemexpress LLC 3-Thiazolidinepropanoic acid, 5-(5-chloro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)-4-oxo-2-thioxo- | 1426138-42-2 | 98.0% | 368.82 g/mol | C14H9ClN2O4S2 | 200 MG
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FX1 is a small-molecule inhibitor of the transcriptional repressor BCL6, used as a research tool to probe BCL6-mediated transcriptional regulation and apoptosis. It is supplied as a solid and is suitable for biochemical and cellular studies.
- Inhibits BCL6 with IC50 ≈ 35 μM
- High purity (98.0%) suitable for research applications
- Solid form, pink to red color
- Molecular formula C14H9ClN2O4S2; molecular weight 368.82 g/mol
- Available in multiple pack sizes including 200 MG
- Powder storage: -20°C (3 years) or 4°C (2 years)
- Intended for biochemical assays and cellular pathway studies
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Apexbio Technology LLC Tetracycline(Synonyms: Achromycin, Sumycin, Tetracyn, Tetrex, Panmycin, Robitet, Polycycline, Cyclopar), 200mg, CAS: 60-54-8.
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Tetracycline (CAS 60-54-8) is a broad-spectrum polyketide antibiotic originally isolated from Streptomyces species It functions primarily through reversible binding to the bacterial 30S ribosomal subunit disrupting the interaction of aminoacyl-tRNA with the ribosomal acceptor site and thereby inhibiting bacterial protein synthesis Additionally tetracycline interacts partially with the 50S ribosomal subunit and may compromise bacterial membrane integrity causing leakage of intracellular components Tetracycline remains widely employed in microbiological research as an antibiotic selection marker and a tool for investigating ribosomal functions
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Medchemexpress LLC Sulfo-EGS 25mg | 167410-92-6 | 616.48 | C18H20N2O18S2 | 25 MG
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Sulfo-EGS is a water-soluble, homobifunctional, amine-reactive crosslinker used to probe protein-protein and protein-peptide interactions by forming stable covalent links between proximal lysine residues. It is soluble in water and DMSO and supplied for research use.
- Water-soluble homobifunctional amine-reactive crosslinker.
- Enables covalent crosslinking of proximal lysine residues to map interactions.
- Soluble in water and DMSO for flexible experimental conditions.
- Typical purity of 90.0% suitable for research applications.
- Available in small pack sizes for bench-scale experiments.
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Medchemexpress LLC Apixaban | 503612-47-3 | MFCD11977295 | 99.99% | C25H25N5O4 | 200 MG
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Apixaban is a highly selective, reversible, and orally active inhibitor of Factor Xa. It is used in the prevention and treatment of various thromboembolic diseases.
- Highly selective and orally active factor Xa inhibitor
- Reversible factor Xa inhibition
- Ki values of 0.08 nM in human and 0.17 nM in rabbit
- Used for prevention and treatment of thromboembolic disorders
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Medchemexpress LLC 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid | 846549-37-9 | 98.6% | C22H42N4O12 | 1 G
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2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne-containing molecules. It also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Features an Azide group for CuAAc reactions
- Participates in SPAAC reactions
- Relevant to click chemistry and PROTAC synthesis
- For research use only
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Medchemexpress LLC Alimemazine hemitartrate | 4330-99-8 | 98.4% | 200 MG
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Alimemazine hemitartrate is an antagonist of the histamine (HA) receptor that also acts as a partial agonist at other GPCR receptors. This compound exhibits anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. It promotes pancreatic β-cell growth and improves diabetes in mice. This product is intended for research use only.
- Acts as a histamine (HA) receptor antagonist
- Functions as a partial agonist at GPCR receptors
- Exhibits anti-serotonin, antispasmodic, and antihistamine properties
- Offers sedative, hypnotic, antiviral, and anti-nausea effects
- Promotes pancreatic β-cell growth
- Improves diabetes in mouse models
- Reduces SARS-CoV-2 induced syncytia formation
- Inhibits SARS-CoV-2 in HEK293T/ACE2 and VeroE6/TMPRSS2 cells
- For research use only
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Medchemexpress LLC Argatroban (monohydrate) | 141396-28-3 | 99.6% | 5 MG
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Argatroban (monohydrate) is a direct, selective thrombin inhibitor used for research purposes. It is effective in preventing thrombus formation and has been studied for its use in creating animal models for thrombolysis.
- Suitable for high-speed applications
- Available in solid form
- Used to inhibit thrombin activity in animals
- Has potential for preventing thrombus formation without aggravating bleeding
- Can enhance reperfusion with TPA in patients with AMI
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