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Filtered Search Results
eMolecules 4-Chloro-6,7-difluoro-quinoline-3-carbonitrile | 886362-75-0 | MFCD06796586 | 25g
Combi-Blocks | 4-Chloro-6,7-difluoro-quinoline-3-carbonitrile | 25g | 448004410 | OR-6955 | 98.000 | 886362-75-0 | MFCD06796586 | 224.590 | C10H3ClF2N2
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5000365842 ISTRADEFYLLINE 200MG
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![Medchemexpress LLC 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate | 406205-74-1 | MFCD09027365 | 98.6% | 453.36 g/mol | C18H13F6NO4S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000214106.png-250.jpg)
Medchemexpress LLC 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate | 406205-74-1 | MFCD09027365 | 98.6% | 453.36 g/mol | C18H13F6NO4S | 10 MG
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Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with demonstrated analgesic activity. It binds human CB1 and CB2 receptors (Ki 48.3 nM and 45.5 nM) and shows antihyperalgesic and antiallodynic effects in rodent pain models.
- Selective CB1/CB2 receptor partial agonist.
- High affinity for human CB1 (Ki ~48.3 nM) and CB2 (Ki ~45.5 nM).
- Demonstrated antihyperalgesic and antiallodynic effects in rodent models.
- High purity (98.6%) and solid, white to off-white appearance.
- Highly soluble in DMSO (≥ 100 mg/mL).
- Stable when stored as powder at -20°C (up to 3 years) or 4°C (up to 2 years).
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Apexbio Technology LLC LFM-A13 244240-24-2 200mg
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LFM-A13 (CAS 244240-24-2) is a small-molecule inhibitor targeting Bruton s tyrosine kinase (BTK) a cytoplasmic enzyme implicated in the signaling pathways regulating the growth and differentiation of B-lineage lymphoid cells LFM-A13 demonstrates high selectivity for BTK exhibiting an IC50 value of 17 2 M in kinase assays and shows minimal activity against other protein tyrosine kinases even at elevated concentrations In preclinical models LFM-A13 enhances the efficacy of standard chemotherapeutic regimens and increases survival rates in mice challenged with BCL-1 leukemia cells Currently LFM-A13 is under investigation in preclinical research settings
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5000432018 SULFO-CY3 AMINE 50MG
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5000432544 SUGAMMADEX SODIUM 200MG
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Apexbio Technology LLC PIK-294 900185-02-6 200mg
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PIK-294 (CAS 900185-02-6) is a potent and highly selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) isoform p110 with an IC50 of 10 nM It exhibits substantially reduced activity against PI3K PI3K and PI3K demonstrating a 1 000-fold 49-fold and 16-fold lower potency respectively Biochemical studies indicate that PIK-294 interacts with a high-affinity pocket in the ATP-binding site contributing to its inhibitory properties in vitro Used as a chemical probe PIK-294 aids in delineating isoform-specific PI3K functions such as the distinct roles of PI3K isoforms in insulin signaling and cellular differentiation pathways No clinical studies have been reported
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5000452987 8-HYDROXYQUINOLINE 10MM 1ML
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5000452986 8-HYDROXYQUINOLINE 5G
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5000452985 8-HYDROXYQUINOLINE 100MG
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5000427282 CINCHONIDINE 50G
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5000377303 CDK2-IN-31 5MG
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Apexbio Technology LLC Fluocinolone Acetonide 67-73-2 200mg
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Fluocinolone Acetonide (67-73-2) is a glucocorticoid receptor (GR) agonist targeting the GR It is designed to modulate intracellular signaling pathways mediated by the GR thereby regulating inflammatory response and influencing lipid metabolism by reducing lipid accumulation in tissues Fluocinolone Acetonide exerts its biological activity primarily through activation of the GR In cellular assays Fluocinolone Acetonide demonstrates stimulation of proliferation in dental pulp cells (DPCs) Based on these pharmacological properties Fluocinolone Acetonide holds research potential in studies of dental tissue regeneration and repair as well as in investigations of preventative and therapeutic strategies for chemotherapy-induced peripheral neuropathy
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5000387553 LONGDAYSIN 200MG
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Apexbio Technology LLC AZ5104 1421373-98-9 200mg
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AZ5104 (CAS 1421373-98-9) is a demethylated metabolite of AZD9291 functioning as a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It exhibits high affinity for mutant EGFR forms with IC50 values below 1 nM for EGFR L858R/T790M 6 nM for EGFR L858R 1 nM for EGFR L861Q and 25 nM for wild-type EGFR Compared to AZD9291 AZ5104 demonstrates increased potency in cellular models harboring EGFR ex19del (PC-9) T790M (H1975) and wild-type EGFR (LOVO) In vivo oral administration in mice led to a plasma metabolite level of 33% at 3 hours post-dose and 5 mg/kg/day reduced tumor growth in relevant models AZ5104 serves as a valuable tool for studying EGFR-driven cancer mechanisms and resistance
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