Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1,141 – 1,155 of 5,526 results

1,141

eMolecules 898747-24-5 | 5-Bromo-1H-indazole-7-carboxylic acid methyl ester | J & W PharmLab LLC | MFCD08458991 | 255.071 | C9H7BrN2O2 | 96.000 | COC(=O)c1cc(Br)cc2cn[nH]c12 | 5g | 289352063

5-Bromo-1H-indazole-7-carboxylic acid methyl ester | J & W PharmLab LLC | 898747-24-5 | MFCD08458991 | 255.071 | C9H7BrN2O2 | 96.000 | COC(=O)c1cc(Br)cc2cn[nH]c12 | 5g | 289352063

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1,142

Medchemexpress LLC Rivastigmine (ENA 713 free base) | 123441-03-2 | 99.9% | 250.34 | 200 MG

Rivastigmine (ENA 713 free base) | 123441-03-2 | 99.9% | 250.34 | 200 MG

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1,143

Apexbio Technology LLC KNK437 218924-25-5 200mg

KNK437 (CAS 218924-25-5) is a benzylidene lactam small molecule that inhibits stress-induced synthesis of heat shock proteins (HSPs) HSPs function as molecular chaperones with increased expression under cellular stress and involvement in protein folding cancer and cardiovascular disease KNK437 suppresses the induction of various HSPs in human colon carcinoma cells (COLO 320DM) including after heat stress and arsenite exposure thereby preventing the development of thermotolerance in a dose-dependent manner In murine tumor models KNK437 reduces Hsp72 synthesis when administered prior to hyperthermia This compound is widely used to investigate HSP-mediated stress responses and mechanisms of thermotolerance in cancer research

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1,144

Medchemexpress LLC 1H-Imidazole-2-carbaldehyde | 10111-08-7 | MFCD00003544 | 96.09 | 10 G

1H-Imidazole-2-carbaldehyde is a biochemical reagent suitable for life science research as a biological material or organic compound. This compound acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor with potential applications in suppressing type-2 diabetes.

Can be used as a biological material or organic compound for life science related research.
Acts as a novel protein tyrosine phosphatase 1B (PTP1B) inhibitor.
Has potential application to suppress type-2 diabetes.
Used in the preparation of tridentate Schiff-base carboxylate-containing ligands by condensation reaction with amino acids.
Involved in the study of imidazole-directed allylation of aldimines.

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1,145

Medchemexpress LLC Methotrexate metabolite | 19741-14-1 | MFCD00075774 | 98.4% | 325.33 g/mol | C15H15N7O2 | 200 MG

Methotrexate metabolite (DAMPA) is the primary active metabolite of methotrexate, supplied as an analytical standard for laboratory research, pharmacokinetic, and metabolism studies. It is intended for use as a reference standard in analytical assays and for investigation of methotrexate metabolism and clearance.

Active metabolite of methotrexate used as an analytical standard.
Suitable for pharmacokinetic and metabolism research.
Molecular formula C15H15N7O2.
Molecular weight 325.33 g/mol.
Purity 98.4% (HPLC).
Supplied as a solid for laboratory use.
Not for human or veterinary use.

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1,146

Medchemexpress LLC 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine | 1262618-39-2 | 99.6% | 347.22 | C14H7F6N3O | 200MG

GS967 (GS-458967) is a potent, selective inhibitor of the cardiac late sodium current (late INa) used as a research tool in preclinical electrophysiology and arrhythmia studies. It preferentially blocks persistent NaV1.5 currents and has reported IC50 values of 0.13 μM in ventricular myocytes and 0.21 μM in isolated hearts.

Potent, selective late INa inhibition suitable for arrhythmia research.
Reported IC50: 0.13 μM (ventricular myocytes), 0.21 μM (isolated hearts).
High purity (approximately 99.6%), with certificate of analysis available.
Molecular formula C14H7F6N3O; molecular weight 347.22 g/mol.
Supplied as a powder; recommended storage -20°C for long-term storage, -80°C for solutions.
Available in multiple package sizes to support assay development and in vivo studies.

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1,147

Apexbio Technology LLC Palifosfamide 31645-39-3 200mg

Palifosfamide (CAS 31645-39-3) is the active metabolite derivative of ifosfamide (IFA) an alkylating agent exhibiting cytotoxic effects through cross-linking DNA strands thereby interfering with replication and transcription Palifosfamide lysine demonstrates anticancer activity against pediatric sarcoma cell lines including osteosarcoma models such as SAOS-2 (IC50 2 25 6 75 M) and decreased sensitivity in OS222 (IC50 31 5 M) In murine xenograft experiments (MX-1 tumors) palifosfamide treatment at 100 mg/kg showed substantial tumor growth inhibition ( 80%) and partial complete response rates ( 17%) highlighting its applicability in preclinical oncology research

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1,148

Apexbio Technology LLC Torin 2 1223001-51-1 200mg

Torin 2 (CAS 1223001-51-1) is a selective orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) exhibiting an EC50 of approximately 0 25 nM Structurally improved from Torin 1 Torin 2 interacts via hydrogen bonding with residues V2240 and Y2225 in mTOR and two additional interactions between its aniline amino group and residues D2195 and D2357 enhancing potency and pharmacokinetic properties It displays high selectivity for mTOR over phosphoinositide 3-kinases (PI3Ks) and other protein kinases by nearly 800-fold Due to these properties Torin 2 is extensively studied in oncological research targeting mTOR signaling pathways

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1,149

eMolecules 63875-01-4 | 2-methylpyridine-4-carbaldehyde | Pharmablock | MFCD06410683 | 121.139 | C7H7NO | 97.000 | Cc1cc(C=O)ccn1 | 500mg | 551305104

2-methylpyridine-4-carbaldehyde | Pharmablock | 63875-01-4 | MFCD06410683 | 121.139 | C7H7NO | 97.000 | Cc1cc(C=O)ccn1 | 500mg | 551305104

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1,150

Apexbio Technology LLC SR1078 1246525-60-9 200mg

SR1078 (CAS 1246525-60-9) is a small-molecule agonist targeting retinoic acid receptor-related orphan receptors alpha and gamma (ROR and ROR ) It is designed to selectively activate these nuclear receptors thereby regulating transcriptional processes involved in metabolic homeostasis and immune responses SR1078 exerts its biological activity primarily through direct binding to the ligand-binding domains of ROR and ROR promoting receptor-mediated transcription In in vitro studies treatment of HepG2 cells with SR1078 enhances ROR-driven gene expression including upregulation of glucose-6-phosphatase and fibroblast growth factor 21 mRNA levels Based on these pharmacological properties SR1078 holds research potential in studying ROR / -mediated biological pathways and their physiological functions

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1,151

Medchemexpress LLC 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile | 131341-86-1 | MFCD01631158 | 98.0% | 248.19 g/mol | C12H6F2N2O2 | 200 MG

Fludioxonil is a phenylpyrrole fungicide supplied as an analytical standard (CAS 131341-86-1) for laboratory research and method development. The material is provided as a high-purity solid suitable for reference, calibration, and analytical assays.

High purity (98.0%) suitable for analytical applications.
Molecular formula C12H6F2N2O2 and molecular weight 248.19 g/mol.
Supplied as a stable solid for reliable storage and handling.
Suitable for method development, calibration, and reference standards.
Compatible with HPLC and GC analytical techniques.

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1,152

Apexbio Technology LLC Sotalol 3930-20-9 200mg

Sotalol (CAS 3930-20-9) is a non-selective adrenergic beta-receptor antagonist that inhibits both 1- and 2-adrenergic signaling pathways By blocking these receptors sotalol reduces sympathetic stimulation of the myocardium leading to decreased heart rate and myocardial contractility Furthermore it exhibits class III antiarrhythmic properties by prolonging cardiac action potential duration through inhibition of potassium channels Sotalol is utilized in biomedical research for investigating mechanisms underlying arrhythmogenesis and for evaluating therapeutic strategies in models of life-threatening ventricular and supraventricular arrhythmias

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1,153

Medchemexpress LLC Azatadine (dimaleate) | 3978-86-7 | 99.85% | 200 MG

Azatadine dimaleate is an inhibitor of histamine and cholinergic with an IC50 of 6. It also exhibits antiserotonin activity and can be used in research on perennial allergic rhinitis.

Inhibitor of histamine and cholinergic
Exhibits antiserotonin activity
Can be studied in research on perennial allergic rhinitis
Targets histamine receptor
Involves GPCR/G protein, immunology/inflammation, and neuronal signaling pathways

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1,154

Apexbio Technology LLC MI-2(Synonyms: Menin-MLL Inhibitor MI-2, MI2, MI 2, Menin inhibitor MI-2), 200mg, CAS: 1271738-62-5.

MI-2 (CAS 1271738-62-5) is a small molecule inhibitor targeting the menin-MLL protein-protein interaction with an IC50 of 0 45 M The formation of menin-MLL fusion protein complexes resulting from chromosomal rearrangements plays an essential role in the pathogenesis of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) MI-2 selectively binds wild-type menin disrupting its interaction with MLL-fusion proteins such as MLL-AF9 thereby inhibiting cellular proliferation and colony formation in MLL-AF9-transduced mouse bone marrow cells MI-2 serves as a research tool in studies of leukemia biology and menin-associated oncogenesis

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1,155

Apexbio Technology LLC KN-92 176708-42-2 200mg

KN-92 is a structurally related but inactive analog of the CaMKII inhibitor KN-93 primarily utilized as a negative control compound in investigations of Ca2 /calmodulin-dependent kinase II (CaMKII) function Unlike KN-93 KN-92 does not effectively interfere with the binding of calmodulin (CaM) to the CaMKII enzyme and does not demonstrate substantial inhibition of CaMKII catalytic activity As a molecular control KN-92 allows researchers to distinguish between CaMKII-specific inhibitory effects and potential non-specific cellular influences when employing KN-93 in experimental models KN-93 itself selectively interacts with the CaM-binding region of CaMKII impeding enzyme activity implicated in cellular responses such as calcium-induced calcium release in cardiac cells histamine-stimulated aminopyrine uptake in gastric parietal cells and calcium-dependent induction of HIF-1 in cancer cells

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Quinolines and derivatives

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Medchemexpress LLC Rivastigmine (ENA 713 free base) | 123441-03-2 | 99.9% | 250.34 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1H-Imidazole-2-carbaldehyde | 10111-08-7 | MFCD00003544 | 96.09 | 10 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Methotrexate metabolite | 19741-14-1 | MFCD00075774 | 98.4% | 325.33 g/mol | C15H15N7O2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine | 1262618-39-2 | 99.6% | 347.22 | C14H7F6N3O | 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 4-(2,2-difluoro-1,3-benzodioxol-4-yl)-1H-pyrrole-3-carbonitrile | 131341-86-1 | MFCD01631158 | 98.0% | 248.19 g/mol | C12H6F2N2O2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Azatadine (dimaleate) | 3978-86-7 | 99.85% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More