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Filtered Search Results
Medchemexpress LLC Lificiguat | 170632-47-0 | 99.7% | 304.34 | 200 MG
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Lificiguat (YC-1) is a soluble guanylyl cyclase (sGC) activator that binds to the β subunit of sGC. It stimulates sGC activity, especially in the presence of CO or NO, leading to several hundred-fold activation. This compound has also been shown to inhibit tumor growth and improve rodent learning behavior.
- Binds to the β subunit of soluble guanylyl cyclase (sGC)
- Activates sGC, synergistically with carbon monoxide or nitric oxide
- Inhibits tumor growth
- Improves rodent learning behavior
- Enhances long-term potentiation (LTP)
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Apexbio Technology LLC Fludarabine(Synonyms: Fludarabine Phosphate, Fludara, Fludarabinum, 2-Fluoro-ara-AMP, 9H-Purin-6-amine), 200mg, CAS: 21679-14-1.
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Fludarabine (CAS 21679-14-1) is a purine analog prodrug that inhibits DNA synthesis Upon cellular uptake it undergoes phosphorylation to its active triphosphate form (F-ara-ATP) disrupting DNA replication through inhibition of critical enzymes such as DNA primase DNA ligase I ribonucleotide reductase and DNA polymerases and In human myeloma RPMI8226 cell assays fludarabine suppressed cell growth reduced Akt phosphorylation and lowered anti-apoptotic proteins XIAP and Survivin In vivo studies demonstrated marked tumor growth inhibition in RPMI8226 xenograft models Fludarabine serves as a tool in oncology research particularly leukemia and multiple myeloma-related studies
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Apexbio Technology LLC PF-431396 717906-29-1 200mg
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PF-431396 is a pyrimidine-based small-molecule inhibitor targeting proline-rich tyrosine kinase 2 (Pyk2) and focal adhesion kinase (FAK) It is designed to selectively inhibit these kinases thereby modulating signaling pathways involved in cellular adhesion migration and proliferation PF-431396 exerts its biological activity primarily through disruption of Pyk2 and FAK tyrosine autophosphorylation or transphosphorylation Based on these pharmacological properties PF-431396 holds research potential in the investigation of cancer biology inflammation and immunological cell responses in experimental models
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Apexbio Technology LLC Trospium chloride 10405-02-4 200mg
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Trospium chloride (CAS 10405-02-4) is a quaternary ammonium compound that functions as a competitive antagonist at muscarinic acetylcholine receptors thereby inhibiting cholinergic stimulation of the bladder detrusor muscle This action reduces involuntary bladder contractions leading to decreased urinary urgency frequency and urge incontinence Trospium chloride displays pharmacological properties distinct from tertiary amine antimuscarinics including limited central nervous system penetration It is widely utilized in preclinical and clinical research focused on urinary disorders and muscarinic receptor pharmacology
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Apexbio Technology LLC KY 02111 1118807-13-8 200mg
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KY 02111 (CAS 1118807-13-8) is a selective inhibitor of the Wnt signaling pathway acting downstream of GSK3 and APC within the -catenin destruction complex By modulating canonical Wnt signaling KY 02111 has been shown to significantly reduce luciferase reporter activity in IMR90-1 human induced pluripotent stem cells (hiPSCs) transfected with a TCF-responsive plasmid in a dose-dependent manner When applied to differentiating cardiac cell colonies KY 02111 induces the expression of cardiac-specific markers in approximately 73 85% of IMR90-1 hiPSCs by day 30 This compound is valuable for investigating Wnt-mediated cellular processes and optimizing protocols for directed differentiation of pluripotent stem cells
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TARGETMOL CHEMICALS INC 9-Phenanthrol 200MG
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Also available in 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. 9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. Purity 98.72%
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Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg
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Cobicistat (GS-9350) is a selective inhibitor of cytochrome P450 3A enzyme (CYP3A) showing inhibitory activity with an IC50 ranging from 0 03 to 0 285 M in vitro It lacks intrinsic anti-HIV activity but serves primarily as a pharmacokinetic enhancer used in combination therapy to increase the systemic exposure of HIV-1 protease inhibitors such as atazanavir and darunavir Clinically cobicistat is administered orally to HIV-1-infected adults facilitating optimized dosing regimens Due to its selective CYP3A inhibitory mechanism cobicistat is employed in pharmacokinetic studies and drug-drug interaction investigations related to HIV treatments
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Medchemexpress LLC Argatroban monohydrate | 141396-28-3 | MFCD23102419 | 99.6% | 1 ML
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Argatroban monohydrate is a direct, selective thrombin inhibitor. It may also have a complementary effect for preventing thrombus formation without aggravating bleeding tendency due to its monotarget specificity to thrombin.
- Administration (0.5 to 2 micrograms/kg/min) is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries.
- Appears to enhance reperfusion with TPA in patients with AMI, particularly in those with delayed presentation, and was associated with lower incidences of major bleeding and adverse clinical outcomes compared to heparin.
- Suitable for creating animal models for thrombolysis.
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Medchemexpress LLC 4,6-diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione | 6381-55-1 | MFCD00052358 | 98.6% | 266.36 g·mol⁻¹ | C16H14N2S | 200 MG
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KKII5 is a small-molecule research inhibitor of lipoxygenase (LOX-1) used to study lipid peroxidation pathways; it has an IC50 of 19 μM and is supplied as a high-purity solid or as a DMSO solution for biochemical and cell-based assays.
- Inhibits lipoxygenase (LOX-1) with an IC50 of 19 μM.
- Inhibits lipid peroxidation in biochemical assays.
- High purity (98.6%) suitable for research use.
- Available as solid in multiple sizes and as a 10 mM solution in DMSO.
- Stable when stored as powder at -20 °C or 4 °C; in solvent at -80 °C or -20 °C.
- Molecular formula C16H14N2S; molecular weight 266.36 g·mol⁻¹.
- CAS number 6381-55-1 for unambiguous identification.
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eMolecules Chem-Impex N N -Disuccinimidyl carbonate 5kg 342449122 02309 0 000 74124-79-1 MFCD00009767 256 170 C9H8N2O7
Chem-Impex N N -Disuccinimidyl carbonate 5kg 342449122 02309 0 000 74124-79-1 MFCD00009767 256 170 C9H8N2O7
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Medchemexpress LLC Recombinant rat B7-H2 (ICOSLG) protein, His-tagged | >95.0% | 10 UG
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Recombinant rat B7-H2 (ICOSLG) extracellular domain (E25-K261) expressed in HEK293 cells with C-terminal His tag. Purified to ≥95.0% and supplied as a research-grade recombinant protein for receptor-ligand binding assays, ELISA, flow cytometry controls, and cell signaling studies.
- Extracellular domain E25-K261 (rat ICOSLG)
- Expressed in HEK293 mammalian cells
- C-terminal His tag for purification and detection
- Purity ≥95.0%
- Suitable for binding assays, ELISA, and cell signaling studies
- Available in multiple microgram sizes for research use
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eMolecules 2-HYDROXYQUINOLINE-6-CARBOXYLIC ACID | 70639-78-0 | MFCD11007961 | 1g
AstaTech | 2-HYDROXYQUINOLINE-6-CARBOXYLIC ACID | 1g | 323612351 | K10089 | 95.000 | 70639-78-0 | MFCD11007961 | 189.170 | C10H7NO3
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![Medchemexpress LLC 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[2-(1-azetidinylsulfonyl)phenyl]-7-methyl-2-(3-methyl | 3055550-22-3 | 99.9% | 423.49 g·mol⁻¹ | C20H21N7O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000285839.png-250.jpg)
Medchemexpress LLC 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[2-(1-azetidinylsulfonyl)phenyl]-7-methyl-2-(3-methyl | 3055550-22-3 | 99.9% | 423.49 g·mol⁻¹ | C20H21N7O2S | 10 MG
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EGFR-IN-86 is a small-molecule epidermal growth factor receptor (EGFR) inhibitor reported to have an IC50 of 1.5 nM. It has demonstrated activity in glioblastoma models, inducing apoptosis and causing G2/M cell-cycle arrest in U87 cells. Supplied as a high-purity research compound (99.92%), it is intended for in vitro and preclinical studies. Molecular formula C20H21N7O2S; molecular weight 423.49 g·mol⁻¹.
- Potent EGFR inhibition with a reported IC50 of 1.5 nM.
- Demonstrated activity in glioblastoma models, inducing apoptosis.
- Induces G2/M cell-cycle arrest in U87 cells.
- High purity suitable for research applications.
- Supplied in small research-friendly quantities for laboratory use.
- Molecular formula C20H21N7O2S and molecular weight 423.49 g·mol⁻¹.
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Apexbio Technology LLC Tempo 2564-83-2 200mg
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Tempo (CAS 2564-83-2) is a stable nitroxide radical widely employed in biomedical research for its redox-active properties It facilitates the dismutation of superoxide radicals thereby modulating mitochondrial reactive oxygen species (ROS) levels and influencing cellular oxidative stress responses Tempo also serves as an oxidation catalyst particularly in the transformation of primary alcohols to aldehydes Studies indicate that Tempo exerts both antioxidant and mutagenic effects inducing DNA strand breaks and displaying cytotoxic and mutagenic activities in in vitro models such as murine lymphoma cells It is utilized for investigating oxidative stress redox regulation and chemical mutagenesis
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eMolecules Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 50mg 272386939 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
Chem-Impex Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt 50mg 272386939 23033 0 000 92921-24-9 MFCD00054978 436 370 C16H17N2NaO9S
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