Quinolines and derivatives
Apexbio Technology LLC Quinine HCl Dihydrate 6119-47-7 10g
Quinine HCl Dihydrate is a quinoline alkaloid hydrochloride salt presented as a dihydrate form It exerts its biological activity primarily through interference with heme detoxification mechanisms within Plasmodium species disrupting parasite-mediated heme metabolism and inducing cytotoxic free heme accumulation At the molecular level quinoline derivatives may inhibit nucleic acid synthesis affecting DNA replication and transcription events during erythrocytic lifecycle stages Researchers frequently utilize Quinine HCl Dihydrate for studies on antimalarial drug mechanisms parasite resistance pathways and as a reference standard in pharmacological and pharmacokinetic assessments
Medchemexpress LLC Quinine hydrochloride dihydrate | 6119-47-7 | 99.7% | 5 G
Quinine hydrochloride dihydrate is an orally active anti-malarial agent that functions as a potassium channel inhibitor. It has demonstrated inhibitory effects on WT mouse Slo3 (KCa5.1) channel currents and on the proliferation and cytostatic effects of Dengue virus (DENV) in human hepatocarcinoma HepG2 cells. Additionally, it has shown some tumor-suppressing effects on skin cancer in Swiss albino mice.
- Acts as a potassium channel inhibitor
- Inhibits WT mouse Slo3 (KCa5.1) channel currents
- Inhibits Dengue virus proliferation and cytostatic effects in HepG2 cells
- Reduces viral DENV RNA and protein levels
- Shows tumor-suppressing effects on skin cancer
- Molecular weight: 396.91
- Appearance: white to off-white solid
- In vitro solubility: soluble in DMSO (≥ 100 mg/mL) and H2O (20 mg/mL)
- For research use only
Medchemexpress LLC Quinine hydrochloride dihydrate | 6119-47-7 | 99.7% | 10 G
Quinine hydrochloride dihydrate is an orally active compound primarily used in anti-malarial studies. It functions as a potassium channel inhibitor, specifically targeting WT mouse Slo3 (KCa5.1) channel currents. This compound has also demonstrated effects against Dengue virus proliferation in HepG2 cell lines and exhibited some tumor-suppressing activity in skin cancer models.
- Acts as a potassium channel inhibitor
- Inhibits WT mouse Slo3 (KCa5.1) channel currents
- Inhibits DENV proliferation and cytostatic effects in HepG2 cell lines
- Reduces viral DENV RNA and protein levels
- Shows tumor-suppressing effects on skin cancer in mice
Medchemexpress LLC Quinine hydrochloride dihydrate | 6119-47-7 | 99.7% | 1 ML
Quinine hydrochloride dihydrate (Qualaquin) is an orally active anti-malarial agent and a potassium channel inhibitor. It inhibits WT mouse Slo3 (KCa5.1) channel currents with an IC50 of 169 μM.
- Used in anti-malarial studies.
- Inhibits WT mouse Slo3 (KCa5.1) channel currents.
- Shows antiviral activity against DENV (Dengue virus) in human HepG2 cell lines.
- May have tumor-suppressing effects on skin cancer in Swiss albino mice.
- Impacts the antioxidant defense system in rat testicular tissue.
Apexbio Technology LLC Quinine HCl Dihydrate 6119-47-7 10mM (in 1mL DMSO)
Quinine HCl Dihydrate is a quinoline alkaloid hydrochloride salt presented as a dihydrate form It exerts its biological activity primarily through interference with heme detoxification mechanisms within Plasmodium species disrupting parasite-mediated heme metabolism and inducing cytotoxic free heme accumulation At the molecular level quinoline derivatives may inhibit nucleic acid synthesis affecting DNA replication and transcription events during erythrocytic lifecycle stages Researchers frequently utilize Quinine HCl Dihydrate for studies on antimalarial drug mechanisms parasite resistance pathways and as a reference standard in pharmacological and pharmacokinetic assessments
AdipoGen Quinine HCl dihydrate
Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
AdipoGen Quinine HCl dihydrate
Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.
AdipoGen Quinine HCl dihydrate
Chemical. CAS 6119-47-7. Formula C20H24N2O2 . HCl . 2H2O. MW BD9837. Quinine hydrochloride dihydrate is isolated from the cinchona tree?s bark, is characterized by a bitter taste and shows antipyretic fever-reducing, anti-malarial, analgesic painkilling, anti-viral and anti-inflammatory properties. Quinine also possesses, at high concentrations, antibacterial properties, which suggests it has potential as an antimicrobial adjuvant. It is believed to impede the activity of enzymes associated with nucleic acid and protein biosynthesis and act as an antagonist for specific neurotransmitters, including serotonin. Quinine acts as a competitive inhibitor of monoamine oxidase MAO, an enzyme that removes neurotransmitters from the brain and a general potasssium channel blocker. Quinine is a flavor component of tonic water and bitter lemon drink mixers.