Tetrapyrroles and derivatives
Abcam Dorsomorphin (Compound C), AMP-kinase inhibitor, 5MG
MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable. Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
The product is subject to the following: Abcam Restricted Use Statement
Abcam ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist, 25MG
MW 283.41 Da, Purity >99%. Selective protease-activated receptor 2 (PAR2) antagonist (IC₅₀ = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 5-Aza-2'-deo x ycytidine (Decitabine), DNMT1 inhibitor, 10MG
MW 228.21 Da, Purity >99%. Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC₅₀ = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antio x idant, 100MG
MW 164.3 Da. Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Zinc phthalocyanine | 14320-04-8 | 98.0% | 577.90 | 5 G
Zinc phthalocyanine (ZnPc) is commonly applied in industry as catalysts and photoconductors, and in biomedical fields for photodynamic therapy (PDT). It can be used to photooxidise cyclohexane and is promising for research in solar-cell applications.
- Inhibits the growth of cancer cells Kyse-140 and OE-33 with IC50 values of 1.41 μM and 3.35 μM respectively (1-10 μM, 24 h).
- Acts as a photosensitizer that is taken up by cancer cells and produces Reactive Oxygen Species (ROS) under specific wavelength light irradiation (694 nm).
- Impairs mitochondrial membrane integrity, activates caspase-3, and induces apoptosis.
- Causes long-term damage to the microvascular network of the CAM (10 μM, topical application, single dose).
- Exhibits antitumor activity in chick chorioallantoic membrane models.
Abcam (S)-(-)-Raclopride, D2 receptor antagonist, 10MG
MW 347.24 g/mol, Purity >97%. High affinity (Kd = 1.2 nM) and high selectivity for D₂ receptors in vitro and in vivo (IC₅₀ = 32 nM). Centrally active following systemic administration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Desmethyl YM298198 hydrochloride, Analogue of mGlu1 antagonist YM298198, 50MG
MW 364.9 Da, Purity >99%. Derivative of mGlu1 antagonist YM298198 (ab120015). Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ODQ, NO-sensitive guanylyl cyclase inhibitor, 50MG
MW 187.15 Da, Purity >99%. Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam WAY-100635 maleate, 5-HT1A receptor antagonist, 10MG
MW 538.6 Da, Purity >98%. Potent, selective, silent 5-HT1A receptor antagonist (IC50 = 1.35 nM). Displays >100-fold selectivity for 5-HT1Arelative to a range of other CNS receptors including other 5-HT subtypes, adrenoceptors, dopamine, GABA, histamine and ion channels. Binds selectively to rodent brain 5-HT1A receptors *in vivo* (iv admin). Unlike WAY100135, WAY100635 displays no partial agonist activity in the ventral hippocampus of rats.
The product is subject to the following: Abcam Restricted Use Statement
Frontier Specialty Chemicals 1G PHTHALOCYANINE
This item has a minimum qty of 3 per supplier requirements.
Phthalocyanine; CAS No: 574-93-6
Abcam PNU 120596, Positive allosteric modulator for alpha7 nicotinic acetylcholine receptors, 50MG
MW 311.72 Da, Purity >99%. Competitive, type II positive allosteric modulator for α7nAChR (EC₅₀ = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Flupirtine maleate, Neuronal potassium channel opener, 25MG
MW 420.4 Da, Purity >99%. Neuronal potassium channel opener. Activates Kv7.2 channels and potently activates the inwardly rectifying potassium current (KIR; EC₅₀ = 600 nM). Centrally acting, non-opiate analgesic. Neuroprotective and antiapoptotic agent. Also has muscle relaxant properties. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC 2-Amino-2-(4-chlorophenyl)acetic acid | 6212-33-5 | 185.61 | 500 G
2-Amino-2-(4-chlorophenyl)acetic acid is a glycine derivative. Amino acids and their derivatives, like this product, are commercially used as ergogenic supplements. They are known to influence the secretion of anabolic hormones, supply fuel during exercise, enhance mental performance during stress-related tasks, and help prevent exercise-induced muscle damage, making them beneficial as ergogenic dietary substances.
- Influences secretion of anabolic hormones
- Supplies fuel during exercise
- Enhances mental performance during stress-related tasks
- Helps prevent exercise-induced muscle damage
Medchemexpress LLC 4-Amino-N-(2-chlorophenyl)benzamide | 888-79-9 | MFCD00628973 | 97% | C13H11ClN2O | 250 MG
4-Amino-N-(2-chlorophenyl)benzamide | 888-79-9 | MFCD00628973 | 97% | C13H11ClN2O | 250 MG
Medchemexpress LLC Chlorophyll b | 519-62-0 | MFCD00079053 | 95.0% | 908.48 g·mol⁻¹ | C55H71MgN4O6+ | 500 UG
Chlorophyll b is a naturally occurring tetrapyrrole pigment used in plant physiology and biochemical research. It functions in light harvesting for photosynthesis and exhibits antioxidant activity, making it suitable for studies of photosynthetic mechanisms, oxidative stress, and protective effects against DNA damage.
- Natural tetrapyrrole pigment for photosynthesis research.
- Antioxidant activity; may increase glutathione levels.
- Useful in assays for oxidative stress and DNA damage protection.
- Available in microgram and milligram research sizes for flexible dosing.
- High purity suitable for laboratory assays and analytical work.
- Molecular data provided to support experimental calculations.