Thiophenes
eMolecules 6164-79-0 | methyl pyrazine-2-carboxylate | Pharmablock | MFCD00014611 | 138.126 | C6H6N2O2 | 97.000 | COC(=O)c1cnccn1 | 5g | 596114927
methyl pyrazine-2-carboxylate | Pharmablock | 6164-79-0 | MFCD00014611 | 138.126 | C6H6N2O2 | 97.000 | COC(=O)c1cnccn1 | 5g | 596114927
![eMolecules 1013-23-6 | Dibenzo[b,d]thiophene 5-oxide | ChemScene | MFCD00046902 | 200.260 | C12H8OS | 96.000 | O=s1c2ccccc2c2ccccc12 | 25g | 711937355](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000473679.jpg-250.jpg)
eMolecules 1013-23-6 | Dibenzo[b,d]thiophene 5-oxide | ChemScene | MFCD00046902 | 200.260 | C12H8OS | 96.000 | O=s1c2ccccc2c2ccccc12 | 25g | 711937355
Dibenzo[b,d]thiophene 5-oxide | ChemScene | 1013-23-6 | MFCD00046902 | 200.260 | C12H8OS | 96.000 | O=s1c2ccccc2c2ccccc12 | 25g | 711937355
![eMolecules 127025-34-7 | THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | AstaTech | MFCD08059495 | 170.240 | C7H6OS2 | 95.000 | OCc1cc2sccc2s1 | 1g | 342445113](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502180630.JPG-250.jpg)
eMolecules 127025-34-7 | THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | AstaTech | MFCD08059495 | 170.240 | C7H6OS2 | 95.000 | OCc1cc2sccc2s1 | 1g | 342445113
THIENO[3,2-B]THIOPHEN-2-YLMETHANOL | AstaTech | 127025-34-7 | MFCD08059495 | 170.240 | C7H6OS2 | 95.000 | OCc1cc2sccc2s1 | 1g | 342445113
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | ≥98% | 581.71 | 1 ML
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells, leading to mitochondrial apoptosis. It also exhibits broad-spectrum antifungal and antibiofilm activity against various fungal pathogens, including fluconazole-resistant strains and mature biofilms.
- Targets mitochondrial tyrosine phosphatase (PTPMT1).
- Induces mitochondrial apoptosis.
- Shows broad-spectrum antifungal activity against diverse fungal pathogens.
- Effective against fluconazole-resistant Candida isolates.
- Inhibits filamentation and proliferation of fungi.
- Decimates mature biofilms of Candida, Cryptococcus, and Aspergillus species at low concentrations.
- Inhibits lateral yeast formation and biofilm dispersal in C. albicans.
- Reduces fungal biofilm growth and viability by 67% in C. albicans murine models.
Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 50 MG
DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It demonstrates significant in vitro and in vivo efficacy, inhibiting KDM1A and reducing colony forming ability in THP-1 cells. In mouse leukemia models, oral administration of DDP-38003 dihydrochloride led to increased survival.
- Inhibits histone lysine-specific demethylase 1A (KDM1A/LSD1)
- Orally available
- IC50 of 84 nM for KDM1A
- Reduces colony forming ability and induces differentiation of THP-1 cells
- Shows in vivo efficacy in mouse leukemia models
- Potential oral anticancer agent
Medchemexpress LLC Puromycin dihydrochloride | 58-58-2 | MFCD00012691 | 99.9% | 500 MG
Puromycin dihydrochloride is an aminonucleoside antibiotic that inhibits protein synthesis. It blocks protein synthesis after aminoacyl-sRNA formation, leading to the accumulation of small peptides. It induces premature termination of translation by serving as an acceptor substrate and by competing with aminoacyl-tRNA for binding to the A' site. This allows for direct evaluation of translation activity in single cells using immunofluorescence microscopy and in heterogeneous cell populations via fluorescence-activated cell sorting.
- Aminonucleoside antibiotic
- Inhibits protein synthesis
- Blocks protein synthesis after aminoacyl-sRNA formation
- Leads to the accumulation of small peptides
- Causes premature termination of translation
- Allows direct evaluation of translation activity in single cells by immunofluorescence microscopy and in heterogeneous cell populations by fluorescence-activated cell sorting
Apexbio Technology LLC Pramipexole 2HCl Monohydrate 191217-81-9 10mM (in 1mL DMSO)
Pramipexole 2HCl Monohydrate is a synthetic non-ergoline dopamine receptor agonist targeting dopamine receptor subtypes particularly D3 D2S D2L and D4 It is designed to activate these receptors thereby modulating dopaminergic transmission pathways Pramipexole 2HCl Monohydrate exerts its biological activity primarily through selective receptor activation Based on these pharmacological properties Pramipexole 2HCl Monohydrate holds research potential in studies of receptor-ligand interactions receptor subtype functional analysis and dopamine-related neurologic or psychiatric disorders including Parkinson s disease and restless legs syndrome
Apexbio Technology LLC GSK-LSD1 2HCl 2102933-95-7 10mM (in 1mL DMSO)
GSK-LSD1 2HCl (CAS 2102933-95-7) is a selective irreversible inhibitor of lysine-specific demethylase 1A (LSD1) a flavin-dependent histone demethylase that modulates mono- and dimethylated lysine residues and is implicated in processes such as oocyte growth and tissue-specific differentiation GSK-LSD1 2HCl inhibits LSD1 with an IC50 of 16 nM and exhibits over 1000-fold selectivity against related FAD-utilizing enzymes including LSD2 MAO-A and MAO-B In cancer cell lines it demonstrates EC50 values below 5 nM for both gene expression modulation and growth inhibition GSK-LSD1 2HCl serves as a valuable chemical probe in epigenetics and cancer research
Medchemexpress LLC Acetyl-CoA Carboxylase-IN-1 | 179343-23-8 | C13H9Br2N5 | 100 MG
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of less than 5 nM. It also exhibits antibacterial activity. This product is for research use only and not intended for sale to patients.
- Potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of less than 5 nM
- Exhibits antibacterial activity
- Demonstrates antibacterial activity against E. coli with varying MIC values depending on the strain
Medchemexpress LLC Netropsin dihydrochloride | 18133-22-7 | 1 MG
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic. It inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. It also possesses antibacterial and antiviral activity.
- Potential antibiotic and antiviral properties by binding to dsDNA in a non-intercalative manner.
- Improves survival from murine endotoxaemia by attenuating NOS2 induction through interference with HMGA1 DNA binding to the core NOS2 promoter.
- Radioprotective ability against radiation-induced damage in solutions of DNA due to high binding affinity and structural stabilization.
Aobchem 2-(4-Chlorophenyl)-5-iodothiophene | 95% | CAS 2182049-22-3 | C10H6ClIS | 250mg
2-(4-Chlorophenyl)-5-iodothiophene | 95% | CAS 2182049-22-3 | C10H6ClIS | 250mg
Aobchem 3 6-Dibromo-2-fluorobenzaldehyde | ≥97% | CAS 870703-68-7 | C7H3Br2FO | 25g
3 6-Dibromo-2-fluorobenzaldehyde | ≥97% | CAS 870703-68-7 | C7H3Br2FO | 25g
Aobchem 4-Decylthiophene-2-carboxylic acid | 95% | CAS 2969309-22-4 | C15H24O2S | 1g
4-Decylthiophene-2-carboxylic acid | 95% | CAS 2969309-22-4 | C15H24O2S | 1g
Sigma Aldrich Fine Chemicals Biosciences 2-Methylthianaphthene 97% | 1195-14-8 | MFCD00216250 | 1G
2-Methylthianaphthene 97% | Purity: 97% | Mol Wt: 148.22 | 1195-14-8 | MFCD00216250 | 1G
