Thiophenes
Medchemexpress LLC (±)-Decursinol | 5993-18-0 | 5 MG
(±)-Decursinol is a potent FtsZ inhibitor. It inhibits *B. anthracis* FtsZ polymerization with an IC50 of 102 μM. This compound is provided as a white to light yellow solid.
- Potent FtsZ inhibitor
- Inhibits *B. anthracis* FtsZ polymerization with an IC50 of 102 μM
- White to light yellow solid
- For research use only
Medchemexpress LLC Roflupram 10mg | 1093412-18-0 | 10 MG
Roflupram is a selective, orally active, brain-penetrant phosphodiesterase 4 (PDE4) inhibitor used in preclinical research. It exhibits potent activity against human PDE4 catalytic domains and has been reported to reverse cognitive deficits and reduce production of pro-inflammatory factors.
- Selective PDE4 inhibitory activity (IC50 26.2 nM).
- High purity (99.45%).
- Molecular formula C16H20F2O4; molecular weight 314.32 g·mol-1.
- Soluble in DMSO (≈100 mg/mL) and compatible with several in vivo formulations.
- Stable when stored under recommended conditions (pure form: -20°C for up to 3 years).
Medchemexpress LLC Fluzoparib 10mg | 1358715-18-0 | 10 MG
Fluzoparib is a potent, orally active PARP-1 inhibitor used for preclinical research into DNA repair and PARP-targeted cancer therapies. It shows sub-nanomolar enzymatic potency and has demonstrated activity in homologous recombination-deficient cancer models, with practical formulations for laboratory use.
- Potent PARP-1 inhibition (IC50 ≈ 1.46 nM)
- Selective activity against homologous recombination-deficient cells
- Sensitizes cells to cytotoxic agents
- Suitable for in vitro and in vivo preclinical studies
- Available as small solid quantities and DMSO solution formats
Medchemexpress LLC Roflupram 5mg | 1093412-18-0 | 5 MG
Roflupram is a selective, orally active, brain-penetrant phosphodiesterase 4 (PDE4) inhibitor used as a research compound for preclinical pharmacology and biochemical studies. Packaged as a 5 mg solid for laboratory use.
- Selective PDE4 inhibition with reported IC50 26.2 nM
- Brain-penetrant and orally active in preclinical models
- Reported to reverse cognitive deficits and reduce pro-inflammatory factor production
- High purity suitable for biochemical assays
- Soluble in DMSO for solution preparations
Medchemexpress LLC VB124 (MCT4 inhibitor) | 2230186-18-0 | MFCD34602725 | 98.9% | C23H23ClN2O4 | 10MG
VB124 is an orally active, potent, and selective monocarboxylate transporter 4 (MCT4) inhibitor used in research to block lactate import and export. It exhibits low-nanomolar cellular activity (IC50 = 8.6 nM for import, 19 nM for export in MDA-MB-231 cells) and is applied in studies of cancer metabolism, cardiac hypertrophy, and heart failure.
- Selective MCT4 inhibition.
- Low-nanomolar potency in cellular assays.
- Redirects glycolytic carbon flux toward mitochondria.
- Available as solid and DMSO solution formulations.
- Recommended storage for powder and solvent formulations.
- High reported purity (~98.9%).
Apexbio Technology LLC Dorsomorphin 2HCl 1219168-18-9 50mg
Dorsomorphin 2HCl (CAS 1219168-18-9) is a small-molecule inhibitor targeting BMP signaling through selective blockade of BMP type I receptors ALK2 ALK3 and ALK6 It prevents phosphorylation of downstream effectors SMAD1/5/8 with an IC50 of approximately 0 47 mM Originally identified by zebrafish phenotypic screening as a disruptor of embryonic dorsoventral patterning Dorsomorphin has been employed to dissect BMP-regulated pathways in iron homeostasis significantly affecting hepcidin expression and iron metabolism in vitro and in vivo It is widely utilized in mechanistic studies of BMP function and signaling regulation
Apexbio Technology LLC Dorsomorphin 2HCl 1219168-18-9 5mg
Dorsomorphin 2HCl (CAS 1219168-18-9) is a small-molecule inhibitor targeting BMP signaling through selective blockade of BMP type I receptors ALK2 ALK3 and ALK6 It prevents phosphorylation of downstream effectors SMAD1/5/8 with an IC50 of approximately 0 47 mM Originally identified by zebrafish phenotypic screening as a disruptor of embryonic dorsoventral patterning Dorsomorphin has been employed to dissect BMP-regulated pathways in iron homeostasis significantly affecting hepcidin expression and iron metabolism in vitro and in vivo It is widely utilized in mechanistic studies of BMP function and signaling regulation