Triazines
Medchemexpress LLC Triglycidyl isocyanurate | 2451-62-9 | 99.6% | 297.26 | 10 G
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. It inhibits the growth of non-small-cell-lung cancer cells via p53 activation and induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research.
- Antiangiogenic and antineoplastic activities
- Inhibits the growth of non-small-cell-lung cancer cells via p53 activation
- Induces cell apoptosis
- Can be used for cancer research
Medchemexpress LLC 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2-oxiranylmethyl)- | 2451-62-9 | 99.6% | 297.26 | 1 ML
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide that exhibits antiangiogenic and antineoplastic activities. It inhibits the growth of non-small-cell-lung cancer cells by activating p53 and induces cell apoptosis. It can be used for cancer research.
- Antiangiogenic activity
- Antineoplastic activity
- Inhibits the growth of non-small-cell-lung cancer cells via p53 activation
- Induces cell apoptosis
- Applicable for cancer research
Medchemexpress LLC Triglycidyl isocyanurate | 2451-62-9 | 99.6% | 297.26 | 5 G
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. It inhibits the growth of non-small-cell-lung cancer cells via p53 activation, induces cell apoptosis, and can be used for cancer research.
- Reduces spheroid growth of human non-small-cell-lung cancer cells in culture.
- Inhibits akt1/2/3 expression and phosphorylated Aktser473/474/472 in tumorspheres.
- Cleavage of PARP and procaspase-3, with emergent active caspase-3 fragment, are visible in H460 and A549 tumorspheres.
- Suppresses xenograft tumor growth in nude mice without affecting weight.
Selleck Chemical LLC Vacuolin-1-5mg
Vacuolin-1 is a potent and cell-permeable inhibitor that blocks the Ca(2+)-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. Vacuolin-1 is also a potent and selective PIKfyve inhibitor, and inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition.
Medchemexpress LLC 5-Aza-4'-thio-2'-deoxycytidine | 169514-76-5 | 99.1% | 244.27 | 25 MG
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. It is a sulfur-containing deoxy-cytidine analog with potential for DNA hypomethylating and antitumor effects.
- Orally active DNA methyltransferase I (DNMT1) inhibitor
- Sulfur-containing deoxy-cytidine analog
- Potential for DNA hypomethylating and antitumor effects
- Inhibits leukemia cell lines and decreases viability in carcinoma lines
- Depletes DNMT1 in various cell types
- Induces CpG demethylation and re-expression of the p15 tumor suppressor gene
- Effective against NCI-H23 tumor xenografts
- Decreases DNMT1 levels in tumors and provides modest suppression of tumor growth in certain xenograft models
Medchemexpress LLC 1-Methylnicotinamide chloride | 1005-24-9 | 99.9% | 172.61 | 1 ML
TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite known for its antithrombotic and anti-inflammatory activities.
- Exhibits antithrombotic properties
- Shows anti-inflammatory effects
- Acts as an endogenous metabolite
- Relevant to metabolic disease research
- Induces G-actin polymerization in vitro
- Demonstrates anti-inflammatory activity in endothelial cells
Apexbio Technology LLC TRIGLYCIDYL ISOCYANURATE-500mg
Triglycidyl Isocyanurate (Teroxirone) (CAS No 2451-62-9) is a compound commonly used in biomedical research due to its ability to modify proteins and nucleic acids Originating from synthetic chemistry it primarily acts by alkylating nucleophilic sites in biological molecules interfering with DNA and protein functions Its mechanism involves the formation of cross-links which is a crucial factor in its in vitro activity often in the nanomolar to low micromolar range This compound is utilized in cell models and animal studies to investigate cellular responses and for drug screening applications Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC TRIGLYCIDYL ISOCYANURATE-1g
Triglycidyl Isocyanurate (Teroxirone) (CAS No 2451-62-9) is a compound commonly used in biomedical research due to its ability to modify proteins and nucleic acids Originating from synthetic chemistry it primarily acts by alkylating nucleophilic sites in biological molecules interfering with DNA and protein functions Its mechanism involves the formation of cross-links which is a crucial factor in its in vitro activity often in the nanomolar to low micromolar range This compound is utilized in cell models and animal studies to investigate cellular responses and for drug screening applications Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC Nintedanib (BIBF 1120) 656247-17-5 25mg
Nintedanib (BIBF 1120 CAS 656247-17-5) is an orally bioavailable small-molecule tri-kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR1-3) fibroblast growth factor receptors (FGFR1-3) and platelet-derived growth factor receptors (PDGFR / ) By inhibiting these receptor pathways at nanomolar concentrations (IC50 20 100 nmol/L) Nintedanib disrupts angiogenesis signaling and demonstrates antiangiogenic activity It is extensively investigated in preclinical and clinical research for idiopathic pulmonary fibrosis (IPF) as well as oncology including non-small-cell lung carcinoma ovarian cancer colorectal cancer and hepatocellular carcinoma
Apexbio Technology LLC AZOMETHINE-H-MONOSODIUM-100MG
Azomethine-H monosodium (CAS No 5941-07-1) is a compound widely used in biomedical research particularly in the field of analytical chemistry for its role as a colorimetric reagent Originating from the reaction of salicylaldehyde and primary amines it forms stable complexes with metal ions Its mechanism of action involves the chelation of metal ions often utilized in determining the presence of trace metals In vitro its activity is typically observed in the nanomolar to low micromolar range allowing for precise quantitative measurements It is commonly applied in various experimental setups including cell models and animal studies where it aids in the screening and determination of metal ion concentrations Azomethine-H monosodium is valued for its specificity and sensitivity which makes it a crucial tool in drug screening and chemical analysis Experimental concentrations typically depend on the specific research design ensuring its versatility across different studies
Apexbio Technology LLC AZOMETHINE-H-MONOSODIUM-500MG
Azomethine-H monosodium (CAS No 5941-07-1) is a compound widely used in biomedical research particularly in the field of analytical chemistry for its role as a colorimetric reagent Originating from the reaction of salicylaldehyde and primary amines it forms stable complexes with metal ions Its mechanism of action involves the chelation of metal ions often utilized in determining the presence of trace metals In vitro its activity is typically observed in the nanomolar to low micromolar range allowing for precise quantitative measurements It is commonly applied in various experimental setups including cell models and animal studies where it aids in the screening and determination of metal ion concentrations Azomethine-H monosodium is valued for its specificity and sensitivity which makes it a crucial tool in drug screening and chemical analysis Experimental concentrations typically depend on the specific research design ensuring its versatility across different studies