Carboximidamides
Medchemexpress LLC PIN1 inhibitor API-1 50mg | 680622-70-2 | 366.30 | C15H13F3N6O2 | 50 MG
PIN1 inhibitor API-1 is a selective peptidyl-prolyl cis-trans isomerase Pin1 inhibitor (IC50 = 72.3 nM) that binds the Pin1 PPIase domain and has been reported to up-regulate anticancer microRNA biogenesis and suppress hepatocellular carcinoma in preclinical models.
- Selective Pin1 inhibitor (IC50 72.3 nM).
- Molecular formula C15H13F3N6O2; molecular weight 366.30.
- Purity 99.63%.
- Appearance solid; color white to yellow.
- Soluble in DMSO (250 mg/mL); in vivo formulations ≥ 2.17 mg/mL in mixed solvents.
- Available in multiple package sizes including 50 MG.
Medchemexpress LLC PXS-5120A | 2125955-70-4 | 98.1% | 100 MG
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. It exhibits high selectivity for LOXL2 over LOXL and effectively inhibits various forms of LOXL2 and LOXL3. In vivo studies demonstrate its rapid absorption and hydrolysis to the active free base, maintaining therapeutic plasma concentrations for extended periods.
- Potent, irreversible fluoroallylamine inhibitor of LOXL2/3
- Exhibits anti-fibrotic activity
- Over 300-fold selective for LOXL2 over LOXL
- Effectively inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, and collagen oxidation assay
- Inhibits recombinant human LOXL3 and recombinant human LOXL4
- Readily absorbed orally and rapidly hydrolyzed to the active free base
- Maintains plasma concentrations above LOXL2 IC50 for prolonged periods in mice
STA Pharmaceutical ANA 2'-F U amidite | 1 g | CAS 1190089-70-3 | MDL MFCD15145421
ANA 2'-F U amidite is a Amidite reagent (Subcategory: ANA Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 1190089-70-3
- MDL: MFCD15145421
- InChIKey: HQHQPAYRJJMYQX-CPBIVIIKSA-N
- Molecular Weight: 748.789165161
- Molecular Formula: C39H46FN4O8P
- Purity: ≥98%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(NC(C=C5)=O)=O)F)OCCC#N)C(C)C)C
TARGETMOL CHEMICALS INC CLONIDINE 100MG
Also available in 50 mg and bulk. Please contact Fisher for quotes. Clonidine (Kapvay) is a centrally active alpha-adrenergic agonist used predominantly as an antihypertensive agent usually in combination with other agents. Despite wide-scale use for many years clonidine has not been linked definitively to either serum aminotransferase elevations or clinically apparent liver injury. purity: 99%
Medchemexpress LLC 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2 | 1121931-70-1 | 99.9% | C23H29N3O3 | 50 MG
CM398 is a highly selective, orally active sigma-2 receptor ligand with a Ki of 0.43 nM. It demonstrates a high sigma-1/sigma-2 selectivity ratio (1000-fold).
- Exhibits notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM).
- Shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice.
Sigma Aldrich Fine Chemicals Biosciences Creatine Phosphokinase fro
CREATINE Creatine Phosphokinase fro
Medchemexpress LLC Vas 3947 | 869853-70-3 | MFCD06751667 | 99.6% | 310.33 | C14H10N6OS | 5 MG
VAS 3947 is a small-molecule NADPH oxidase (NOX) inhibitor used in research to inhibit NOX-dependent reactive oxygen species production. It is supplied as a white to off-white solid and is commonly used in studies of ROS signaling, platelet function, and apoptosis.
- High purity suitable for biological studies
- Solid, white to off-white appearance for easy handling
- Molecular formula C14H10N6OS and molecular weight 310.33
- Available in small research quantities such as 5 MG
- Recommended storage: powder -20°C for long-term stability
Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 50 G
Guanidine hydrochloride is a strong chaotrope and a strong denaturant of proteins, intended for research use only.
- Refolds acid-unfolded apomyoglobin and cytochrome c at low concentrations.
- Causes co-operative unfolding of the molten globule state at concentrations greater than 1 M.
- Does not affect ordered structure remaining due to disulfide bonds.
- Causes efficient loss of the normally stable [PSI+] element from yeast cells at millimolar concentrations.
- Reduces Hsp104-mediated basal and acquired thermotolerance.
- Reduces Hsp104's ability to restore activity of thermally denatured luciferase.
- Significantly reduced death rate of infant mice infected with coxsackievirus A16 in vivo.
Apexbio Technology LLC MRTX-1133(Synonyms: MRTX1133, MRTX 1133, Mirati-1133, KRAS G12D inhibitor MRTX1133), 10mg, CAS: 2621928-55-8.
MRTX-1133 (CAS 2621928-55-8) is a non-covalent alkyne-based inhibitor specifically targeting the KRAS G12D mutant protein It binds KRAS G12D with sub-picomolar affinity occupying the Switch II pocket and forming multiple intermolecular interactions Through these interactions MRTX-1133 disrupts SOS1-mediated guanine nucleotide exchange and prevents the assembly of KRAS-GTP/RAF1 signaling complexes thereby inhibiting downstream KRAS-driven signaling pathways MRTX-1133 is applied in cancer biology research to investigate tumor signaling and therapeutic strategies involving KRAS G12D mutations