Carboximidamides
Medchemexpress LLC BNC375 | 1557240-80-8 | 99.6% | 10 MG
BNC375 is a potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs with an EC50 of 1.9 μM. It exhibits good CNS-agent like properties and clinical candidate potential. BNC375 significantly potentiates the acetylcholine signal without changing the rapid receptor desensitization. In vivo, BNC375 (0.003-10.0 mg/kg, administered orally) exhibits a Minimum Effective Dose (MED) of 0.03 mg/kg, achieving full reversal of scopolamine-induced impairment at 1.0 mg/kg in a mouse T-maze model. It has a plasma half-life (t1/2) of 1.2 hours.
- Potent, selective, and orally available type I positive allosteric modulator of α7 nAChRs.
- Exhibits good CNS-agent like properties.
- Clinical candidate potential.
- Significantly potentiates acetylcholine signal.
- Achieves full reversal of scopolamine-induced impairment in mouse T-maze model.
- Plasma half-life (t1/2) of 1.2 hours.
Medchemexpress LLC Smap-2 (DT-1154) | 1809068-70-9 | 99.5% | 5 MG
SMAP-2 (DT-1154) is a small-molecule, orally active activator of protein phosphatase 2A (PP2A) with demonstrated anti-cancer activity in preclinical studies. It is supplied as a white to off-white solid and includes manufacturer-reported solubility and storage guidance.
- Orally bioavailable PP2A activator with anticancer activity.
- High purity: 99.53% (manufacturer reported).
- Molecular weight 532.57; formula C27H27F3N2O4S.
- Soluble in DMSO (300 mg/mL); in vivo formulation guidance provided.
- Powder storage: -20°C (3 years) or 4°C (2 years); in solvent: -80°C (2 years).
Medchemexpress LLC Siguazodan | 115344-47-3 | 99.1% | 10 MG
Siguazodan is a selective phosphodiesterase 3 (PDE3) inhibitor supplied as a high-purity research reagent. It increases intracellular cAMP, exhibits anti-platelet and vasodilatory activity in preclinical studies, and is provided as a solid suitable for laboratory use.
- Potent and selective PDE3 inhibitor.
- High purity (99.1%).
- Provided as a 10 MG solid for laboratory use.
- Demonstrated anti-platelet and vasodilatory effects in preclinical studies.
- Intended for research and analytical applications only.
AdipoGen 4Me-indotricarbocyanine PF6
Chemical. CAS 134339-08-5. Formula C35H45F6N2P. MW 638.72. Cyanine dye. Spectral Data lambdaex=747nm lambdaem=774nm. Cyanine dyes were first synthesized over a century ago, used to sensitize photographic plates and comprise a diverse family of fluorophores. With their narrow absorption and fluorescence spectral profiles, together with high oscillator strengths for the lowest-energy absorption transition, these dyes are ideal candidates for fluorescence standards for the far-red region.
Medchemexpress LLC Creatine kinase M-type (CKM) protein, human (N-His tag) | 9001-15-4 | >95.0% | 10 UG
Recombinant human creatine kinase M-type (CKM) protein with an N-terminal His tag, expressed in E. coli and supplied as a purified, biologically active enzyme for research use. The protein is approximately 45 kDa, available in microgram quantities, and characterized for activity and purity (>95% by reducing SDS-PAGE). Intended for biochemical assays, enzyme activity studies, and antibody validation; not for clinical or diagnostic use.
- Recombinant human CKM with N-terminal His tag.
- Expressed in E. coli for high-yield production.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Biologically active and suitable for enzymatic assays.
- Supplied in microgram quantities for small-scale experiments.
- Datasheet and COA provided for lot-specific quality information.
Medchemexpress LLC 3-O-Methylquercetin | 1486-70-0 | 316.26 | 5 MG
3-O-Methylquercetin acts as an inhibitor of cAMP and cGMP-phosphodiesterase (PDE) with IC50 values of 13.8 μM and 14.3 μM, respectively. It also inhibits β-secretase with an IC50 of 6.5 μM. This compound demonstrates neuroprotective effects against neuronal death caused by oxidative damage and exhibits strong antiviral activity against poliovirus, coxsackie virus, and human rhinovirus. Additionally, it has anti-inflammatory and trachea-relaxing properties, making it relevant for the study of inflammatory diseases and asthma.Key characteristics include:
- Inhibits cAMP and cGMP-phosphodiesterase.
- Inhibits β-secretase.
- Provides neuroprotection against oxidative damage.
- Exhibits strong antiviral activity.
- Possesses anti-inflammatory and trachea-relaxing effects.
eMolecules 108800-18-6 | 1-(3-(BENZYLOXY)PHENYL)GUANIDINE NITRATE | MFCD21364703 | 1g
Ambeed | 5-Cyclopropylpyridin-2-ol | 100mg | 525115768 | A199306 | 1159821-42-7 | MFCD12033218 | 135.166 | C8H9NO
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Medchemexpress LLC 1H-1,2,3-triazole-4-carboxamide derivative (BIIB091) | 2247614-80-6 | 99.9% | C28H34N10O2 | 10MG
BIIB091 is a potent, selective, reversible Bruton's tyrosine kinase (BTK) inhibitor supplied as a high-purity small-molecule reagent for research and preclinical studies. It is used to probe BTK signaling and to evaluate therapeutic approaches in autoimmune and B-cell-mediated disease models. Not for human or clinical use.
- Potent, selective reversible BTK inhibitor (IC50 <0.5 nM).
- High purity (99.85% by HPLC).
- Molecular formula C28H34N10O2; molecular weight 542.64.
- Suitable for in vitro and preclinical assays.
- Orally active profile reported in preclinical studies.
- Supplied as a powder; soluble in DMSO.
Medchemexpress LLC Creatine kinase M-type (mouse), recombinant, His-tagged | >90.0% | 20UG
Recombinant mouse creatine kinase M-type (CKM) is expressed in E. coli and purified with an N-terminal His tag; it is supplied lyophilized for research use and formulated for stability. The product has >90% purity and an approximate molecular weight of 49.0 kDa; store frozen and follow reconstitution instructions for enzymatic or immunological applications.
- Recombinant mouse CKM with N-terminal His tag.
- High purity (>90%) determined by reducing SDS-PAGE.
- Molecular weight approximately 49.0 kDa.
- Supplied lyophilized for convenient storage and shipping.
- Formulated in 20 mM Tris-HCl, 0.5 M NaCl, 6% trehalose, pH 8.0.
- Suitable for enzymatic assays, antibody production, and biochemical studies.
- Store at -20°C for long-term stability; aliquot to avoid freeze-thaw cycles.
STA Pharmaceutical ANA 2'-F U amidite | 1 g | CAS 1190089-70-3 | MDL MFCD15145421
ANA 2'-F U amidite is a Amidite reagent (Subcategory: ANA Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 1190089-70-3
- MDL: MFCD15145421
- InChIKey: HQHQPAYRJJMYQX-CPBIVIIKSA-N
- Molecular Weight: 748.789165161
- Molecular Formula: C39H46FN4O8P
- Purity: ≥98%
- Container Type: 30 mL Glass (28-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 50.1 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(NC(C=C5)=O)=O)F)OCCC#N)C(C)C)C
eMolecules 1758-73-2 | Formamidinesulfinic acid | Oakwood Chemicals | MFCD00002397 | 108.120 | CH4N2O2S | 98.000 | NC(=N)S(O)=O | 100g | 480166951
Formamidinesulfinic acid | Oakwood Chemicals | 1758-73-2 | MFCD00002397 | 108.120 | CH4N2O2S | 98.000 | NC(=N)S(O)=O | 100g | 480166951
eMolecules 1399191-70-8 | Ambeed | 55-(14-Phenylene)dipicolinaldehyde | 100mg | 603089926 | A1226399 | 288.306 | C18H12N2O2
Medchem Express | SB 242084 | 5mg | 446262835 | HY-13409 | 181632-25-7 | MFCD05662310 | 394.860 | C21H19ClN4O2
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![Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000233883.png-250.jpg)
Medchemexpress LLC 7-ethyl-4-[3-(4-ethylsulfonyl-2-methoxyphenyl)-4-fluorophenyl]imidazo[4,5-c]pyridazine | 1614245-70-3 | 99.3% | 25 MG
Darigabat is an orally active, subtype-selective GABAA positive allosteric modulator used in neuroscience and pharmacology research. It has molecular formula C22H21FN4O3S and molecular weight 440.49 g/mol, and is supplied in small research quantities with high purity.
- Orally active GABAA positive allosteric modulator.
- Subtype-selective for α2/α3/α5 receptor subunits.
- High purity of 99.3% suitable for research applications.
- Molecular weight 440.49 g/mol and formula C22H21FN4O3S.
- Supplied in small-quantity packages for in vitro and in vivo studies.
Medchemexpress LLC Clonidine hydrochloride | 4205-91-8 | 99.9% | 5 G
Clonidine hydrochloride is an agonist of α2-adrenoceptor and a potent antihypertensive agent. It is for research use only.
- Agonist of α2-adrenoceptor
- Potent antihypertensive agent
- Significantly induces CGRP (α and β) mRNA expression in endothelial cells
- Significantly increases NO level in endothelial cells
- Causes a significant decrease in rat body temperature
- Potently suppresses dopamine efflux in the prefrontal cortex
Apexbio Technology LLC Guanidine HCl 50-01-1 10g
Guanidine hydrochloride (Guanidine HCl CAS 50-01-1) is a highly alkaline crystalline compound derived from the oxidative metabolism of guanine Functioning primarily as a strong chaotropic agent it disrupts hydrogen bonding and secondary structure in proteins leading to efficient protein denaturation and solubilization Widely utilized in molecular biology and biochemistry Guanidine HCl facilitates protein unfolding for downstream applications such as protein purification refolding studies and RNA extraction protocols where it also serves to inactivate nucleases and other enzymes