Enamines
Selleck Chemical LLC PF-562271 Besylate S2672-1g
PF-562271 Besylate is the benzenesulfonate salt of PF-562271 which is a potent ATP-competitive reversible inhibitor of FAK with IC50 of 1 5 nM 10-fold less potent for Pyk2 than FAK and 100-fold selectivity against other protein kinases except for some CDKs Phase 1
Med Vet International AmLodipine, 10mg Tablets, 1000 Count
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Amlodipine, 10mg Tablets, 1000 Count
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 g/mol | C27H26F3N7O6S2 | 1 ML
PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 used in biochemical, cell-based, and in vivo research. It is supplied as a 10 mM solution in DMSO and exhibits low-nanomolar activity against FAK and nanomolar activity against Pyk2.
- Potent inhibition of FAK and Pyk2 (FAK IC50 = 1.5 nM; Pyk2 IC50 = 13 nM).
- Supplied as a ready-to-use 10 mM solution in DMSO for in vitro assays.
- High reported purity suitable for research use (99.17%).
- Demonstrated antiproliferative activity across multiple cancer cell lines.
- Validated pharmacological effects in vivo, including inhibition of FAK phosphorylation.
Med Vet International AmLodipine Besylate (Generic Norvasc) Tablets, 10mg, 90ct
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Amlodipine besylate tablets are a type of medicine known as a calcium channel blocker (CCB). It is used to treat high blood pressure (hypertension) and a type of chest pain called angina.
Med Vet International AmLodipine Besylate 5mg, 90 Tablets
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Amlodipine Besylate 5mg, 90 tablets
Sigma Aldrich Fine Chemicals Biosciences Amlodipine besylate European Pharmacopoeia (EP) Reference Standard | 111470-99-6 | MFCD00887594 |
Amlodipine besylate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 567.05 | 111470-99-6 | MFCD00887594 |
Medchemexpress LLC Molibresib besylate | 1895049-20-3 | 97.0% | 1 ML
Molibresib besylate is an orally active pan-BET inhibitor that targets and binds to BRD2, BRD3, BRD4, and BRDT. It competitively occupies acetylated lysine binding sites, disrupting the interaction between BET proteins and chromatin. This action inhibits MYC expression and target gene transcription, demonstrating broad antiproliferative activity by inhibiting cancer cell growth and inducing growth arrest.
- Inhibits cancer cell proliferation and induces cell cycle arrest.
- Downregulates mitosis-related genes and upregulates p-ERK1/2.
- Shows synergistic anti-proliferative effects with MEK inhibitors.
- Reduces tumor burden and prolongs survival in mouse models of leukemia.
- Applicable to research in acute myeloid leukemia, multiple myeloma, triple-negative breast cancer, and other advanced solid tumors.
Medchemexpress LLC To-1187 (TFA) | 98.4% | 795.72 | 50 MG
TO-1187 TFA is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It functions by promoting the ubiquitination and degradation of HDAC6. This compound is suitable for use in research studying hematological malignancies and solid tumors. The compound is composed of an HDAC6 ligand, a CRBN ligase ligand, and a linker.
- Selective HDAC6 PROTAC degrader, exhibits a DC50 of 5.81 nM, indicating potent and specific degradation of HDAC6.
- Promotes ubiquitination and subsequent degradation of HDAC6.
- Useful in the study of hematological malignancies and solid tumors.
- Consists of a specific HDAC6 ligand, a CRBN ligase ligand, and a linker.
- Purity of 98.41%.
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.7 g/mol | C27H26F3N7O6S2 | 1 MG
PF-562271 besylate is an ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) used as a research tool in cell-signaling and oncology studies. It exhibits potent biochemical activity (FAK IC50 ≈ 1.5 nM; Pyk2 IC50 ≈ 13-14 nM), is supplied as the besylate salt, and is available at high purity for in vitro and in vivo research.
- Potent ATP-competitive, reversible inhibitor of FAK and Pyk2.
- Low nanomolar biochemical potency for target kinases.
- Provided as a besylate salt for improved stability and handling.
- High reported purity suitable for research applications.
- Used in cellular and animal model studies of tumor signaling pathways.
Medchemexpress LLC (S)-Nimodipine | 77940-93-3 | 99.9% | 418.44 | 100 MG
(S)-Nimodipine is an enantiomer of Nimodipine, an orally active, well-tolerated, and light-sensitive dihydropyridine calcium antagonist. It is used in the research of cerebrovascular disorders, targeting the Calcium Channel and involving Membrane Transporter/Ion Channel; Neuronal Signaling pathways.
- Enantiomer of Nimodipine
- Orally active dihydropyridine calcium antagonist
- Used in research of cerebrovascular disorders
- Targets Calcium Channel
- Involves Membrane Transporter/Ion Channel; Neuronal Signaling pathway
![Medchemexpress LLC Benzamide, n-hydroxy-3-[1-[(phenylthio)methyl]-1h-1,2,3-triazol-4-yl]- | 1316652-41-1 | MFCD21363002 | 99.3% | 326.37 g/mol | C16H14N4O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000227030.png-250.jpg)
Medchemexpress LLC Benzamide, n-hydroxy-3-[1-[(phenylthio)methyl]-1h-1,2,3-triazol-4-yl]- | 1316652-41-1 | MFCD21363002 | 99.3% | 326.37 g/mol | C16H14N4O2S | 10 MG
NCC-149 is a selective histone deacetylase 8 (HDAC8) inhibitor used in neural differentiation research. It is a small-molecule benzamide derivative (C16H14N4O2S; MW 326.37 g/mol; CAS 1316652-41-1) supplied as a solid with documented purity and batch COA.
- Selective HDAC8 inhibitor useful for neural differentiation studies.
- Batch-specific purity reported at 99.3% (COA).
- Available as a small 10 MG solid suitable for research-scale experiments.
- Solid stable at -20°C for up to 3 years; solvent solutions require colder storage.
- Comes with COA, SDS, and product datasheet for quality and safety information.
Sigma Aldrich Fine Chemicals Biosciences 1-Pyrrolidino-1-cyclopentene 98% | 7148-07-4 | MFCD00003162 | 10G
1-Pyrrolidino-1-cyclopentene 98% | Purity: 98% | Mol Wt: 137.22 | 7148-07-4 | MFCD00003162 | 10G
Medchemexpress LLC CDK2-IN-4 | 1316652-41-1 | 99.3% | 326.37 g/mol | C16H14N4O2S | 5 MG
NCC-149 is a selective histone deacetylase 8 (HDAC8) inhibitor used in cell biology research, including studies of neural differentiation. The product is provided with supporting documentation for purity, handling, and storage, and is available both as a solid and as a DMSO solution.
- Selective HDAC8 inhibitor for neural differentiation studies.
- Documented purity approximately 99.3% based on certificate of analysis.
- Available as a solid and as a 10 mM solution in DMSO.
- Datasheet, certificate of analysis, and safety data sheet provided for quality and safety information.
- Storage recommendations included for powdered material and solutions.
Medchemexpress LLC (S)-Nimodipine | 77940-93-3 | 99.9% | 418.44 | 1 MG
(S)-Nimodipine is an enantiomer of Nimodipine, a light-sensitive dihydropyridine calcium antagonist. This orally active and well-tolerated compound is utilized in the research of cerebrovascular disorders.
- Enantiomer of Nimodipine
- Orally active
- Dihydropyridine calcium antagonist
- Target: Calcium channel
- Pathway: Membrane transporter/ion channel; neuronal signaling
- Appearance: White to off-white solid
- Purity: 99.9%
- Molecular formula: C21H26N2O7
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 | C27H26F3N7O6S2 | 50 MG
PF-562271 besylate is the besylate salt of a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 commonly used in preclinical biochemical and cellular research. It shows low-nanomolar activity against FAK and is supplied at high purity in small-scale packages for laboratory studies.
- Potent ATP-competitive inhibitor of FAK and Pyk2 (FAK IC50 ≈ 1.5 nM; Pyk2 IC50 ≈ 13 nM).
- Reversible mechanism suitable for biochemical assays.
- High purity for research applications (reported ~99.17%).
- Available in multiple small-scale package sizes for laboratory use.
- Suitable for cellular and signaling pathway studies.