Guanidines
Sigma Aldrich Chlorhexidine dihydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich 1,1-Dimethylbiguanide hydrochloride
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Sigma Aldrich Fine Chemicals Biosciences Metformin Related Compound30mg
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Apexbio Technology LLC Metformin 657-24-9 25mg
Metformin (CAS 657-24-9) is a biguanide compound widely employed as an antihyperglycemic agent in type II diabetes research Its primary mechanism involves enhancing insulin sensitivity in peripheral tissues and reducing hepatic gluconeogenesis leading to lower circulating glucose levels without directly inducing hypoglycemia Metformin is also associated with decreased fasting plasma insulin concentrations and modest weight reduction These properties make it a valuable small molecule for investigating metabolic regulation insulin resistance and therapeutic strategies for obesity-associated metabolic disorders in preclinical and clinical studies
Medchemexpress LLC BioE-1115 | 1268863-35-9 | >98.2% | 1 ML
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. It also acts as a potent casein kinase 2α inhibitor with an IC50 of ~10 μM. This compound is intended for research use only.
- Highly selective and potent PAS kinase inhibitor
- Potent casein kinase 2α inhibitor
- Reduces SREBP activity without affecting cell morphology or growth rate
- Decreases insulin resistance, hepatic and serum TAG, and serum glucose in animal models
- Suppresses expression of SREBP-1c target genes
Medchemexpress LLC Phenylbiguanide hydrochloride | 55-57-2 | MFCD00035040 | 99.8% | 213.67 g/mol | C8H12ClN5 | 10 G
Phenylbiguanide hydrochloride is the hydrochloride salt of phenylbiguanide, a selective 5-HT3 receptor agonist supplied as a high-purity research chemical for in vitro pharmacology and neuroscience studies. The material is characterized with standard identifiers, purity specification, and storage guidance for laboratory use.
- Selective 5-HT3 receptor agonist with an EC50 of 3.0 ± 0.1 μM.
- Chemical identifiers: CAS 55-57-2; formula C8H12ClN5; molecular weight 213.67 g/mol.
- High purity solid (≈99.8%) suitable for analytical and pharmacological assays.
- Available in multiple lab-scale pack sizes (10 G-100 G) for research workflows.
- Storage: store at room temperature up to 3 years; in solvent, -80 °C (2 years) or -20 °C (1 year).
- For research use only; not for human or veterinary use.
Med Vet International Metformin Hcl 500mg, 100 Tablets
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Metformin HCL 500mg, 100 Tablets
Medchemexpress LLC Phenylbiguanide | 55-57-2 | MFCD00035040 | 100.0% | 213.67 g/mol | C8H12ClN5 | 100 G
Phenylbiguanide hydrochloride is a research-grade small molecule used as a selective agonist of the 5-HT3 receptor in pharmacology and neuronal signaling studies. It exhibits an EC50 of approximately 3.0 μM and has documented solubility and stability data suitable for laboratory use.
- Selective 5-HT3 receptor agonist (EC50 ≈ 3.0 μM).
- Chemical identity: CAS 55-57-2; formula C8H12ClN5; molecular weight 213.67 g/mol.
- High purity for research applications (COA reports 99.96%).
- Soluble in DMSO (≈40 mg/mL); formulations reported for in vivo dosing.
- Stable as solid at room temperature; defined solvent storage conditions available.
- Suitable for GPCR and neuronal signaling assays and related pharmacology studies.
Med Vet International Metformin, Er, 500mg, 500 Tablets
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Metformin, ER, 500Mg, 500 Tablets
Medchemexpress LLC Metformin | 657-24-9 | 100 MG
Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhanced insulin sensitivity, which makes it useful for the study of type 2 diabetes. It also exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons, and inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. Additionally, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway.
- Inhibits mitochondrial respiratory chain
- Enhances insulin sensitivity
- Reduces liver oxidative and nitrosative stress
- Regulates autophagy-related proteins
- Inhibits tumor cell autophagy and growth of renal cell carcinoma
Medchemexpress LLC Phenylbiguanide hydrochloride | 55-57-2 | 100.0% | 213.67 g/mol | C8H12ClN5 | 1 ML
Phenylbiguanide hydrochloride is a research-grade 5-HT3 receptor selective agonist used in receptor pharmacology and electrophysiology. It is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid forms for preparation. CAS number 55-57-2; reported EC50 ≈ 3.0 ± 0.1 μM.
- Selective 5-HT3 receptor agonist with an EC50 of 3.0 ± 0.1 μM.
- Ready-to-use 10 mM solution in DMSO for in vitro assays.
- High purity suitable for research applications.
- Molecular weight 213.67 g/mol; molecular formula C8H12ClN5.
- Formulation and solubility guidance provided for in vitro and in vivo studies.
Medchemexpress LLC Phenylbiguanide | 102-02-3 | MFCD00179077 | 98.0% | 177.21 g/mol | C8H11N5 | 1 ML
Phenylbiguanide is a selective 5-HT3 receptor agonist used in pharmacology and neuroscience research to probe 5-HT3-mediated responses. It is supplied as a pre-made 10 mM solution in DMSO (1 mL) and is also available in solid forms, offering defined purity and stability for reproducible in vitro and in vivo preparation.
- Selective 5-HT3 receptor agonist with EC50 ≈ 3.0 μM.
- Offered as a 10 mM solution in DMSO and in solid pack sizes.
- High purity (98.0%) for reliable experimental results.
- Soluble in DMSO and water for flexible formulation options.
- Stable under recommended storage conditions for long-term use.
Apexbio Technology LLC Metformin 657-24-9 50mg
Metformin (CAS 657-24-9) is a biguanide compound widely employed as an antihyperglycemic agent in type II diabetes research Its primary mechanism involves enhancing insulin sensitivity in peripheral tissues and reducing hepatic gluconeogenesis leading to lower circulating glucose levels without directly inducing hypoglycemia Metformin is also associated with decreased fasting plasma insulin concentrations and modest weight reduction These properties make it a valuable small molecule for investigating metabolic regulation insulin resistance and therapeutic strategies for obesity-associated metabolic disorders in preclinical and clinical studies