Isocyanates
Sigma Aldrich Fine Chemicals Biosciences Hexamethylene diisocyanate puriss., >=99.0% (GC) | 822-06-0 | MFCD00002047 | 100ML
Hexamethylene diisocyanate puriss., >=99.0% (GC) | Purity: >=99.0% (GC) | Mol Wt: 168.19 | 822-06-0 | MFCD00002047 | 100ML
Sigma Aldrich Fine Chemicals Biosciences Octyl isocyanate 97% | 3158-26-7 | MFCD00013887 | 5G
Octyl isocyanate 97% | Purity: 97% | Mol Wt: 155.24 | 3158-26-7 | MFCD00013887 | 5G
Cayman Chemical 14 15EpEDE Fatty Acids and Der
An EpEDE acid formed from DGLA, either by a strong oxidizing agent or by cytochrome P450 epoxygenases; biological properties are poorly understood
Cayman Chemical Zeaxanthin Fatty Acids and Der
A carotenoid with diverse biological activities; decreases immobility time in the forced swim test and reduces hippocampal levels of IL-6, IL-1β, and TNF-α in a rat model of STZ-induced diabetes at 50 mg/kg; reduces albuminuria, serum levels of urea nitrogen and MDA, and kidney damage in a rat model of STZ-induced diabetic nephropathy; high dietary intake of zeaxanthin is positively correlated with reduced risk of advanced neovascular age-related macular degeneration in humans
Cayman Chemical 14 15EETSI Fatty Acids and Der
A metabolically stable methyl sulfonamide analog of 14(15)-EET; equipotent to 14(15)-EET in vascular agonist activity
Cayman Chemical 16 17EpDPA Fatty Acids and Der
A DHA metabolite derived via epoxidation of the 16,17-double bond; epoxygenase metabolites of DHA have been detected in a mouse model of inflammation
Cayman Chemical Licofelone Fatty Acids and Der
A dual inhibitor of COX-1/COX-2 and 5-LO (IC50s = 0.16 µM and 0.23 µM for human thrombocyte COX and human 5-LO, respectively); decreases levels of PGE2, LTB4, and lipoxins and prevents LPS-stimulated IL-1β expression; causes little or no damage to the gastric mucosa in rabbit parietal cells
Cayman Chemical Perifosine Fatty Acids and Der
An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
Cayman Chemical 14 15EpEDE Fatty Acids and Der
An EpEDE acid formed from DGLA, either by a strong oxidizing agent or by cytochrome P450 epoxygenases; biological properties are poorly understood
Cayman Chemical Licofelone Fatty Acids and Der
A dual inhibitor of COX-1/COX-2 and 5-LO (IC50s = 0.16 µM and 0.23 µM for human thrombocyte COX and human 5-LO, respectively); decreases levels of PGE2, LTB4, and lipoxins and prevents LPS-stimulated IL-1β expression; causes little or no damage to the gastric mucosa in rabbit parietal cells
Cayman Chemical Perifosine Fatty Acids and Der
An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest
Cayman Chemical 19 20EpDPA Fatty Acids and Der
An epoxide metabolite of DHA; formed from DHA by various CYP isoforms; suppresses hCLS formation and liver fibrosis in wild-type mice in a model of NASH at 100 ng/animal, i.p., intraplantar administration induces acute mechanical hyperalgesia in mice
Cayman Chemical LBiopterin Fatty Acids and Der
An intermediate for tetrahydro-L-biopterin; oxidized form of BH4, a NOS cofactor; toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs); rarely found under physiological conditions except in the epidermis of patients with Vitiligo
Cayman Chemical 14 15EETSI Fatty Acids and Der
A metabolically stable methyl sulfonamide analog of 14(15)-EET; equipotent to 14(15)-EET in vascular agonist activity
Cayman Chemical 14 15EpETE Fatty Acids and Der
EDHF is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (NO) and COX-derived (prostacyclin) vasodilators.{6485,7204} CYP450 metabolism of PUFAs, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of EPA (Item No. 90110) and DHA (Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of (±)14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.