Nitrogen mustard compounds
Medchemexpress LLC Mizagliflozin | 666843-10-3 | 99.2% | 564.67 | 100 MG
Mizagliflozin, also known by its synonyms DSP-3235 free base, KGA-3235 free base, and GSK-1614235 free base, is a highly potent and orally active compound primarily recognized as a selective inhibitor of SGLT1 (sodium-glucose cotransporter 1). Its inhibitory constant (Kᵢ) against human SGLT1 is 27 nM, showcasing a remarkable selectivity profile with 303-fold greater potency for SGLT1 compared to SGLT2. This selectivity makes it a promising antidiabetic agent, as it can effectively modify postprandial blood glucose excursion, helping to manage blood sugar levels after meals. Beyond its antidiabetic properties, Mizagliflozin has also demonstrated potential in alleviating chronic constipation, exhibiting a laxative effect in animal models.
- Potent and selective SGLT1 inhibitor
- Orally active compound
- Modifies postprandial blood glucose excursion
- Potential in ameliorating chronic constipation
Medchemexpress LLC Bis(2-chloroethyl)amine-1,1,2,2-d4 hydrochloride | 352431-06-2 | 98.0% | 182.51 | C4H6D4Cl3N | 25mg
Bis(2-chloroethyl)amine-1 1 2 2-d4 (hydrochloride) is the deuterium labeled Bis(2-chloroethyl)amine-1 1 2 2 hydrochloride[1]
Medchemexpress LLC Gamcemetinib (CC-99677) | 1887069-10-4 | 99.1% | 469.94 | 50 MG
Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway. It exhibits an IC50 of 156.3 nM in biochemical assays and an EC50 of 89 nM in cell-based assays.
- Potent, covalent, and irreversible MK2 inhibitor
- Exhibits IC50 of 156.3 nM in biochemical assays and EC50 of 89 nM in cell-based assays
- Extracted from patent WO2020236636, compound 1
- Available in solid and solution forms
- Appearance: Solid, light yellow to yellow color
- Useful for research purposes
- Offers high purity of 99.1%
Medchemexpress LLC Iriflophenone | 52591-10-3 | MFCD20260852 | 98.1% | 246.22 g/mol | C13H10O5 | 10 MG
Iriflophenone is a plant-derived phenolic compound (C13H10O5, MW 246.22) isolated from Aquilaria sinensis and provided for laboratory research; it has been reported to stimulate proliferation of MCF-7 and T-47D human breast cancer cell lines.
- Plant-derived phenolic compound isolated from Aquilaria sinensis.
- Reported to stimulate proliferation of MCF-7 and T-47D human breast cancer cells.
- High purity suitable for in vitro research (reported purity ~98.1%).
- Available as solid or as ready-to-use DMSO solution for cell-based assays.
- Characterized chemical profile with CAS 52591-10-3 and formula C13H10O5.
Medchemexpress LLC Bis(2-chloroethyl)amine hydrochloride | 821-48-7 | MFCD00012515 | 98.0% | 178.49 g/mol | C4H10Cl3N | 50g
Bis(2-chloroethyl)amine hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Medchemexpress LLC 2'-O-Methylisoliquiritigenin | 51828-10-5 | 270.28 | 5 MG
2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA, and GABA pathways, though its effect on the NE pathway is not significant. This compound has shown sedative-hypnotic and anxiolytic effects in mice studies and acts on 5-HT, Dopamine, and GABA Receptors, engaging GPCR/G Protein and Neuronal Signaling pathways. It is intended for research use only.
- Isolated from Arachis species.
- Up-regulates 5-HT, NE, DA, and GABA pathways.
- Acts on 5-HT Receptor, Dopamine Receptor, and GABA Receptor.
- Engages GPCR/G Protein and Neuronal Signaling pathways.
- Has sedative-hypnotic and anxiolytic effects.
- Appears as a solid with a light yellow to yellow color.
Medchemexpress LLC Bis(2-chloroethyl)amine hydrochloride | 821-48-7 | MFCD00012515 | 98.0% | 178.49 | C4H10Cl3N | 25g
Bis(2-chloroethyl)amine hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research
Medchemexpress LLC Bis(2-chloroethyl)amine hydrochloride | 821-48-7 | MFCD00012515 | ≥98.0% | 178.49 g/mol | C4H10Cl3N | 500g
Bis(2-chloroethyl)amine hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research
eMolecules 213211-10-0 | Medchem Express | BIRT 377 | 5mg | 758391260 | HY-110117 | MFCD28166481 | 442.13 | C18H15BrCl2N2O2
Medchem Express | Isoorientin | 1mg | 446275345 | HY-N0767 | 4261-42-1 | MFCD00017433 | 448.380 | C21H20O11
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Medchemexpress LLC Metarrestin | 1443414-10-5 | 99.9% | 100 MG
Metarrestin is a first-in-class small-molecule inhibitor of the perinucleolar compartment (PNC) used in preclinical cancer research to disrupt nucleolar structure and inhibit RNA polymerase I transcription.
- First-in-class perinucleolar compartment inhibitor for preclinical research.
- Disrupts nucleolar structure and inhibits RNA polymerase I transcription.
- Molecular formula C31H30N4O; molecular weight 474.60.
- Purity 99.9% (reported by supplier).
- Available as a 100 MG powder; store powder at -20°C (long term) or 4°C.
- For research use only; not for human or clinical applications.
eMolecules 1801-10-1 | 3-(Trifluoromethyl)benzamide | Ambeed | MFCD00014802 | 189.137 | C8H6F3NO | 98.000 | NC(=O)c1cccc(c1)C(F)(F)F | 1mg | 761204476
3-(Trifluoromethyl)benzamide | Ambeed | 1801-10-1 | MFCD00014802 | 189.137 | C8H6F3NO | 98.000 | NC(=O)c1cccc(c1)C(F)(F)F | 1mg | 761204476
Medchemexpress LLC ML-184 25mg | 794572-10-4 | 470.63 g·mol⁻¹ | C25H34N4O3S | 25 MG
ML-184 is a small-molecule research compound described as a GPR55 agonist and used in cell-based and pharmacological studies. It is supplied as a high-purity solid for laboratory research and is identified by CAS 794572-10-4.
- Acts as a GPR55 agonist for pharmacology and cell studies.
- High reported purity suitable for research applications.
- Molecular formula C25H34N4O3S and molecular weight 470.63 g·mol⁻¹.
- Supplied as a solid in a 25 mg package for benchtop use.
- CAS number 794572-10-4 provides an unambiguous chemical identifier.
Medchemexpress LLC ML-184 5mg | 794572-10-4 | 470.63 g/mol | C25H34N4O3S | 5 MG
ML-184 is a selective GPR55 agonist research compound (CAS 794572-10-4) used to investigate GPR55-mediated signaling. It activates GPR55 with an EC50 of approximately 250 nM, induces ERK1/2 phosphorylation and PKCβII translocation, and has been reported to increase neural stem cell proliferation and promote neuronal differentiation. The supplied material is a 5 mg vial with reported purity of 99.57% and molecular weight 470.63 g/mol.
- Selective GPR55 agonist with EC50 ≈ 250 nM.
- Induces ERK1/2 phosphorylation and PKCβII translocation.
- Shown to increase neural stem cell proliferation and promote neuronal differentiation in vitro.
- High reported purity suitable for research use.
- Supplied as a 5 mg vial for small-scale experiments.
Medchemexpress LLC Mizagliflozin (DSP-3235 free base) | 666843-10-3 | 99.2% | 564.67 g/mol | C28H44N4O8 | 10 MG
Mizagliflozin is a potent, orally active, selective SGLT1 inhibitor used in research on postprandial glucose regulation and constipation amelioration. It exhibits a Ki of approximately 27 nM for human SGLT1 and about 303-fold selectivity versus SGLT2.
- Selective SGLT1 inhibition (Ki ≈ 27 nM).
- High purity (99.2%).
- Molecular formula C28H44N4O8; molecular weight 564.67 g/mol.
- Solid, off-white to light yellow appearance.
- Store at 4°C protected from light; in solution store -80°C for long-term.