Organic nitroso compounds
Sigma Aldrich Fine Chemicals Biosciences Isopentyl nitrite 96% | 110-46-3 | MFCD00002057 | 100ML
Isopentyl nitrite 96% | Purity: 96% | Mol Wt: 117.15 | 110-46-3 | MFCD00002057 | 100ML
Medchemexpress LLC Tripeptide epoxyketone immunoproteasome (LMP-7) inhibitor | 1416709-79-9 | 98.9% | 618.72 g/mol | C37H38N4O5 | 50MG
A selective tripeptide epoxyketone inhibitor of the immunoproteasome LMP7 subunit for biochemical and cellular research. It covalently modifies proteasomal N-terminal threonine active sites and has demonstrated antitumor activity in preclinical studies.
- Selective LMP7 (β5i) immunoproteasome inhibitor.
- Covalently modifies N-terminal threonine active sites.
- Reported IC50 of 22 nM against LMP7.
- Demonstrated inhibition of multiple myeloma cell growth and induction of apoptosis.
- High chemical purity (98.9%).
- Enantiomeric excess 100%.
- Molecular weight 618.72 g/mol and formula C37H38N4O5.
- Supplied in small research pack sizes, e.g., 50 mg.
- For research use only; not for human use.
Medchemexpress LLC L-tryptophanamide, N-((3-methyl-1H-inden-2-yl)carbonyl)-D-alanyl-N-((1S)-2-((2R)-2-methyl-2-oxiranyl | 1416709-79-9 | 98.9% | 618.72 g·mol⁻¹ | C37H38N4O5 | 10MM 1ML
PR-924 is a selective tripeptide epoxyketone inhibitor of the immunoproteasome subunit LMP-7, intended for research use in biochemical and cellular assays. It is supplied in ready-to-use solutions and in solid quantities to support formulation and dosing studies.
- Selective tripeptide epoxyketone LMP-7 inhibitor.
- Available as 10 mM solution in DMSO and multiple solid sizes.
- High reported purity: 98.9%.
- Molecular weight 618.72 g·mol⁻¹; formula C37H38N4O5.
- Soluble in DMSO; in vivo formulation options described for PEG300/tween/saline and corn oil.
- Storage recommendations provided for powder and in solvent to preserve stability.
Pfaltz & Bauer N-nitrosodiethylamine 98% - C | 55-18-5 | 10ml
N-nitrosodiethylamine 98% - C | 55-18-5 | 10ml
![Medchemexpress LLC L-Tryptophanamide, N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]- | 1416709-79-9 | 98.5% | 618.72 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438557-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC L-Tryptophanamide, N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]- | 1416709-79-9 | 98.5% | 618.72 | 100 MG
(R)-PR-924 is an isomer of PR-924 and can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. It covalently modifies proteasomal N-terminal threonine active sites, inhibits growth, and triggers apoptosis in multiple myeloma (MM) cells, demonstrating antitumor activities.
- Can be used as an experimental control.
- Selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor.
- Covalently modifies proteasomal N-terminal threonine active sites.
- Inhibits growth and triggers apoptosis in multiple myeloma (MM) cells.
- Exhibits antitumor activities.
Sigma Aldrich Fine Chemicals Biosciences N-Nitrosodiethylamine Phar1G
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Medchemexpress LLC 4-nitroso hydrochlorothiazide-13C,15N2,d2 | 63779-86-2 | 99.3% | C613CH5D2ClN215N2O5S2 | 100 UG
4-Nitroso hydrochlorothiazide-13C,15N2,d2 is an isotopically labeled compound, primarily used for research purposes. This compound serves as a tracer and an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. The incorporation of stable heavy isotopes like deuterium, 13C, and 15N into drug molecules is a common practice in drug development to facilitate quantitation and to study their pharmacokinetic and metabolic profiles, as deuteration can influence these aspects.
- Used as a tracer in research applications
- Functions as an internal standard for quantitative analysis
- Suitable for use with NMR, GC-MS, or LC-MS techniques
- Incorporates stable heavy isotopes for enhanced research capabilities
Cayman Chemical N-NItroso SarcosIn 250mg
A carcinogen; induces the formation of metastatic liver carcinomas in mice at 225 mg/kg
Cayman Chemical 5-NItroso-8-quInolInol 50mg
An HDAC inhibitor, antitumor agent that at 10 μM can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells; inhibits T. gondii tachyzoite propagation in human fibroblasts (EC50 = 80 nM) and inhibits P. falciparum growth in human red blood cells (EC50 = 1.3 μM)
![Medchemexpress LLC N-nitroso-3-azabicyclo[3.3.0]octane-d4 | 1346604-35-0 | 95.0% | C7H8D4N2O | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000258410.png-250.jpg)
Medchemexpress LLC N-nitroso-3-azabicyclo[3.3.0]octane-d4 | 1346604-35-0 | 95.0% | C7H8D4N2O | 10MG
N-Nitroso-3-azabicyclo[3.3.0]octane-d4 is a deuterium-labeled N-nitroso azabicyclic compound supplied for research use as an isotope-labeled standard. It is intended for use as a tracer or internal standard in quantitative analyses by NMR, GC-MS, or LC-MS, and is provided with specified purity and cold-storage recommendations to maintain stability.
- Deuterium-labeled internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, and LC-MS applications.
- Provided with stated purity of 95.0%.
- Available in multiple small pack sizes, including 10 mg, for trace-level work.
- Recommended storage: pure form at -20°C; in solvent, -80°C for extended stability.
Medchemexpress LLC N-Nitroso-N-methylurea | 684-93-5 | 99.7% | 103.08 | 2 G
N-Nitroso-N-methylurea is a potent carcinogen, mutagen, and teratogen. It acts as a direct-acting alkylating agent that interacts with DNA, targeting multiple animal organs to cause various cancers and/or degenerative diseases. It is also a precursor in the synthesis of diazomethane.
- Potent carcinogen, mutagen, and teratogen
- Direct-acting alkylating agent that interacts with DNA
- Targets multiple animal organs to cause various cancers and/or degenerative diseases
- Precursor in the synthesis of diazomethane
- For research use only
World Precision Instrument SNAP S-Nitroso-N-acetyl-D-penicillamine-SNAP25
SNAP is a stable green crystalline S-nitrosothiol compound that mimics the action of nitric oxide in vivo. It has vasodilatory properties and has been shown to relax isolated bovine coronary artery rings by activating soluble granulate cyclase. This reagent also actuates apoptosis in mouse thymocytes and has been accounted for reversible inactivation of protein Kinase C. SNAP can be used for calibration of all WPI NO sensors. Call for details. M.W. 220.2, Purity > 98% by NMR or TLC.