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Organic nitroso compounds

Organic compounds that contain one or more nitroso functional groups; nitroso consists of a nitrogen atom bonded to an oxygen atom via a double bond in the following structure: R-N=O, where R is a carbon or nitrogen atom.

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1

Medchemexpress LLC Pr-924 | 1416709-79-9 | 98.9% | 618.72 | C37H38N4O5 | 25MG
SDP

PR-924 is a selective tripeptide epoxyketone inhibitor targeting the immunoproteasome subunit LMP-7. It covalently modifies proteasomal N-terminal threonine active sites, exhibits low-nanomolar potency (IC50 ≈ 22 nM), and has demonstrated antiproliferative and pro-apoptotic activity in multiple myeloma models. Intended for research use only.

  • Selective LMP-7 inhibition with low-nanomolar potency (IC50 ≈ 22 nM).
  • Covalent, irreversible mechanism of action for target engagement.
  • Demonstrated antiproliferative and pro-apoptotic activity in preclinical models.
  • High purity to support reproducible experimental results.
  • Available in multiple solid and solution formats for flexible dosing.
  • Supplied for research use only; not for human use.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC (R)-PR-924 | 1416709-79-9 | 98.5% | 618.72 | 50 MG
SDP

(R)-PR-924 is an isomer of PR-924, which can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. It covalently modifies proteasomal N-terminal threonine active sites, inhibits growth, and triggers apoptosis in multiple myeloma (MM) cells, also exhibiting antitumor activities.

  • Selective immunoproteasome subunit LMP-7 inhibitor.
  • Covalently modifies proteasomal N-terminal threonine active sites.
  • Inhibits growth in multiple myeloma (MM) cells.
  • Triggers apoptosis in multiple myeloma (MM) cells.
  • Exhibits antitumor activities.
  • Can be used as an experimental control.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC Tripeptide epoxyketone immunoproteasome (LMP-7) inhibitor | 1416709-79-9 | 98.9% | 618.72 g/mol | C37H38N4O5 | 50MG
SDP

A selective tripeptide epoxyketone inhibitor of the immunoproteasome LMP7 subunit for biochemical and cellular research. It covalently modifies proteasomal N-terminal threonine active sites and has demonstrated antitumor activity in preclinical studies.

  • Selective LMP7 (β5i) immunoproteasome inhibitor.
  • Covalently modifies N-terminal threonine active sites.
  • Reported IC50 of 22 nM against LMP7.
  • Demonstrated inhibition of multiple myeloma cell growth and induction of apoptosis.
  • High chemical purity (98.9%).
  • Enantiomeric excess 100%.
  • Molecular weight 618.72 g/mol and formula C37H38N4O5.
  • Supplied in small research pack sizes, e.g., 50 mg.
  • For research use only; not for human use.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC L-Tryptophanamide, N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]- | 1416709-79-9 | 98.5% | 618.72 | 100 MG
SDP

(R)-PR-924 is an isomer of PR-924 and can be used as an experimental control. PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. It covalently modifies proteasomal N-terminal threonine active sites, inhibits growth, and triggers apoptosis in multiple myeloma (MM) cells, demonstrating antitumor activities.

  • Can be used as an experimental control.
  • Selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor.
  • Covalently modifies proteasomal N-terminal threonine active sites.
  • Inhibits growth and triggers apoptosis in multiple myeloma (MM) cells.
  • Exhibits antitumor activities.

ENCOMPASS_PREFERRED
5

Medchemexpress LLC L-tryptophanamide, N-((3-methyl-1H-inden-2-yl)carbonyl)-D-alanyl-N-((1S)-2-((2R)-2-methyl-2-oxiranyl | 1416709-79-9 | 98.9% | 618.72 g·mol⁻¹ | C37H38N4O5 | 10MM 1ML
SDP

PR-924 is a selective tripeptide epoxyketone inhibitor of the immunoproteasome subunit LMP-7, intended for research use in biochemical and cellular assays. It is supplied in ready-to-use solutions and in solid quantities to support formulation and dosing studies.

  • Selective tripeptide epoxyketone LMP-7 inhibitor.
  • Available as 10 mM solution in DMSO and multiple solid sizes.
  • High reported purity: 98.9%.
  • Molecular weight 618.72 g·mol⁻¹; formula C37H38N4O5.
  • Soluble in DMSO; in vivo formulation options described for PEG300/tween/saline and corn oil.
  • Storage recommendations provided for powder and in solvent to preserve stability.

ENCOMPASS_PREFERRED