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Ammonium salts in which a nitrogen atom (with a +1 formal charge) has four carbon-nitrogen single bonds; this nitrogen could be bonded to four functional groups containing carbon.
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Tetraethylammonium chloride is a non-selective potassium channel blocker. It also acts as a good substrate for organic cation transporter (OCTN1) and has demonstrated antitumor properties. In vitro studies show it inhibits proliferation and increases apoptosis in glioma cells, while in vivo it affects contractility of rat colon and rectum.
Acts as a non-selective potassium channel blocker.
Good substrate for organic cation transporter (OCTN1).
Exhibits antitumor properties.
Inhibits proliferation of C6 and 9L glioma cells.
Increases apoptosis in C6 and 9L glioma cells.
Elevates Bax/Bcl-2 protein ratio.
Increases intracellular ROS in C6 and 9L cells.
Increases amplitude and frequency of contractility of rat colon and rectum.
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Tetrabutylammonium (dihydrogen trifluoride) is a quaternary ammonium salt provided as a high-purity solid reagent for research applications. It is used as a convenient source of dihydrogen trifluoride/fluoride in synthetic chemistry and as an ionic component in specialized electrolyte systems; store sealed and protected from moisture.
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