Quaternary ammonium salts
Medchemexpress LLC Cholic acid 7-sulfate | 60320-05-0 | 99.9% | 100 MG
Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). It acts as a gut-restricted TGR5 agonist, binding to TGR5 on enteroendocrine L cells, inducing GLP-1 secretion, and improving glucose tolerance in a TGR5-dependent manner. Additionally, it serves as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells (MAIT) and the expression of homeostatic gene signatures, influencing MAIT cell development and function. It is primarily used in the research of diabetes and MAIT cell-related immune regulation.
- Selective agonist targeting TGR5.
- Ligand for MHC class I-related protein (MR1).
- Induces GLP-1 secretion and improves glucose tolerance.
- Promotes survival of mucosal-associated invariant T cells (MAIT) and expression of homeostatic gene signatures.
- Mainly used for research in diabetes and MAIT cell-related immune regulation.
Medchemexpress LLC Cholic acid 7-sulfate | 60320-05-0 | 99.9% | 10 MG
Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). It is primarily used in the research of diabetes and MAIT cell-related immune regulation.
- Gut-restricted TGR5 agonist
- Induces GLP-1 secretion and improves glucose tolerance
- Promotes survival of mucosal-associated invariant T cells (MAIT)
- Affects MAIT cell development and function
Medchemexpress LLC Cholic acid 7-sulfate | 60320-05-0 | 99.9% | 25 MG
Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). It functions as a gut-restricted TGR5 agonist, binding to TGR5 on enteroendocrine L cells to induce GLP-1 secretion and improve glucose tolerance in a TGR5-dependent manner. Additionally, it acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells (MAIT) and affecting MAIT cell development and function. This compound is primarily used in the research of diabetes and MAIT cell-related immune regulation.
- Selective agonist targeting TGR5 (EC50=0.17 μM)
- Ligand for MHC class I-related protein (MR1)
- Induces GLP-1 secretion
- Improves glucose tolerance
- Promotes MAIT cell survival
- Used in diabetes research
- Used in MAIT cell-related immune regulation
Medchemexpress LLC Cholic acid 7-sulfate (7-Sulfocholic acid) | 60320-05-0 | 99.9% | 50 MG
Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC50=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, it binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. It also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells (MAIT) and the expression of homeostatic gene signatures, affecting MAIT cell development and function. It is mainly used in the research of diabetes and MAIT cell-related immune regulation.
- Selective agonist targeting TGR5 (EC50=0.17 μM).
- Ligand for MHC class I-related protein (MR1).
- Binds to TGR5 on enteroendocrine L cells.
- Induces GLP-1 secretion and improves glucose tolerance.
- Promotes survival of mucosal-associated invariant T cells (MAIT).
- Used in research of diabetes and MAIT cell-related immune regulation.
Medchemexpress LLC Cholic acid 7-sulfate | 60320-05-0 | 99.9% | 488.63 g/mol | C24H40O8S | 5 MG
Cholic acid 7-sulfate is a sulfated bile acid used as a research compound. It functions as a potent TGR5 (GPBAR1) agonist and an endogenous ligand for MR1, and is used to study bile acid signaling, GLP-1 secretion, glucose tolerance, and MAIT cell biology in metabolic and immunology research.
- High reported purity (99.92%).
- Potent TGR5 agonist (EC50 = 0.17 μM).
- Acts as an MR1 ligand affecting MAIT cell survival and function.
- Suitable for in vitro and in vivo research applications.
- Offered in small research pack sizes for preclinical studies.