Sulfoxides
Medchemexpress LLC 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(2-oxo-2-phenylethyl)-1-(2-phenylethyl)- | 421578-93-0 | 99.81% | C24H21NO3 | 1 ML
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). This compound is for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Via a transmembrane site
Medchemexpress LLC N'-(3-acetylphenyl)-N-(3-(2-methoxyethyl)-2,4-dioxo-1-(2-(piperidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinazolin | 2946701-09-1 | 99.3% | 507.58 g/mol | C27H33N5O5 | 10 MG
COP1-ATGL modulator 1 is an orally active small-molecule research reagent that modulates the COP1-ATGL pathway. It increases ATGL protein expression, reduces ATGL and COP1 ubiquitination, and diminishes lipid accumulation in hepatocytes at nanomolar concentrations. Supplied as a white to off-white solid with high purity and defined storage recommendations for powder and solution.
- Orally active modulator of COP1-ATGL signaling.
- Increases ATGL protein expression at nanomolar concentrations.
- Reduces ATGL and COP1 ubiquitination in cellular assays.
- High purity suitable for research applications.
- Stable solid with recommended low-temperature storage.
Cayman Chemical Sulindac sulfide
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 10MG
Mutant p53 modulator-1 is a small-molecule research reagent reported to modulate mutant p53 and to reduce progression of cancers harboring p53 mutations. It is supplied as a powder for laboratory research and includes stability instructions for storage and handling.
- High purity: 99.9% suitable for analytical and biological studies.
- Defined chemical formula: C27H32F4N8O2 for unambiguous identification.
- Documented stability: powder stable at -20°C for long-term storage.
- Reported activity against mutant p53 to support targeted cancer research.
- Intended for research use only, not for human or clinical use.
Medchemexpress LLC Sulindac sulfide | 49627-27-2 | 98.1% | 100 MG
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity. For research use only. MedChemExpress does not sell to patients.
- Solubility in vitro: DMSO at 50 mg/mL (146.88 mM), requires ultrasonic assistance, use newly opened DMSO due to hygroscopic nature.
- Stock solution storage: -80°C for 6 months; -20°C for 1 month.
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage of powder: -20°C for 3 years; in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 87.3% | 250 MG
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and strongly suppresses the growth of eukaryotes. It targets the outer membrane of Gram-negative bacteria and serves as a selective marker for various organisms, including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Targets outer membrane of Gram-negative bacteria
- Serves as a selective marker for Fonsecaea pedrosoi
- Inhibits protein biosynthesis in prokaryotic cells
- Strongly suppresses growth of eukaryotes, such as fungi
- Sensitizes resistant Escherichia coli strains by eliminating outer membrane resistance
- Mixture of several Streptothricins (primarily D and F)
- Can create channels in the outer membrane
Medchemexpress LLC Yk-2168 | 2571068-74-9 | 98.1% | 315.80 | 1 ML
YK-2168 is a potent and selective CDK9 inhibitor (IC50 of 5.9 nM) that targets the pS2-RNA Pol II C-terminal domain. It induces apoptosis, suppresses CDK9-regulated genes like MYC and Mcl1, and inhibits tumor growth in CDX mice models. This compound is suitable for cancer research, particularly leukemia.
- Potent and selective CDK9 inhibitor (IC50 of 5.9 nM).
- Induces apoptosis and suppresses CDK9-regulated genes.
- Inhibits tumor growth in CDX mice models (80% inhibition at 10 mg/kg).
- Highly selective over CDK1 and CDK2, with no hERG channel inhibition up to 30 μM.
- Reduces pS2-RNA Pol II CTD levels and upregulates cleaved caspase 3.
- Demonstrates good safety in vivo with no significant body weight changes.
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.71% | 522.68 | 1 ML
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. It is for research use only and not sold to patients. This modulator offers protection against cardiac injury.
- Potent CXCR7-binding affinity (Ki=13 nM).
- β-arrestin activity (EC50=11 nM).
- Improved selectivity in the GPCR panel.
- Improved therapeutic index in the hERG patch-clamp assay.
- Moderate to high in vitro turnover in NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells).
- Good aqueous solubility.
- Rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL at 0.25 h (Tmax).
- Reduces cardiac fibrosis in an isoproterenol-induced cardiac injury model in mice.
Medchemexpress LLC Cytochrome P450 1B1 antibody (YA1836) | 10 UL
Cytochrome P450 1B1 antibody (YA1836) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 1B1. It is intended for research use only.
- Rabbit host
- Recombinant, monoclonal
- Species reactivity: Human, mouse, rat
- Immunogen: A synthesized peptide derived from human CYP1B1 aa400-543
- Isotype: IgG
- Appearance: Liquid
- Formulation: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- Storage & stability: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles
- Shipping: Shipping with blue ice
- Applications & dilution ratios: WB (Western Blot): 1:500-1:1000, IHC-P (Immunohistochemistry-Paraffin): 1:50-1:100, FC (Flow Cytometry): 1:50-1:100
- Sensitivity: Endogenous
- Conjugation: Non-conjugated
- Modification: Unmodified
Medchemexpress LLC Cytochrome P450 2E1 Antibody (YA2302) | 50 UL
Cytochrome P450 2E1 Antibody (YA2302) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2E1. It is for research use only and demonstrates endogenous sensitivity. This antibody is supplied as a liquid formulation in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol.
- Involved in fatty acid metabolism and potentially xenobiotic oxidative metabolism.
- Catalyzes hydroxylation of carbon-hydrogen bonds, specifically at the omega-1 position of saturated fatty acids.
- Subcellular localization includes endoplasmic reticulum membrane, microsome membrane, and mitochondrion inner membrane.
- Application in western blot (WB) with a dilution ratio of 1:500-1:1000.
- Species reactivity includes human, mouse, and rat.
- Immunogen is a synthesized peptide derived from human CYP2E1 aa52-114.
Sigma Aldrich Fine Chemicals Biosciences DL-Sulforaphane | 4478-93-7 | MFCD00198068 | 5 mg
DL-Sulforaphane | Purity: 90% | Mol Wt: 177.29 | 4478-93-7 | MFCD00198068 | 5 mg
