Sulfoxides
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.05% | 315.80 | 50 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits the phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. This product can be used for cancer research, including leukemia.
- Potently inhibits purified CDK9 enzymatic activity
- Exhibits high selectivity over CDK1 and CDK2
- Inhibits proliferation of MV4-11 leukemia cells
- Induces dose-dependent inhibition of tumor growth in CDX mice models
- Suppresses CDK9-regulated gene expression
- Upregulates cleaved caspase 3, indicating induced apoptosis
- Maintains a good safety profile in vivo with no significant body weight changes
Medchemexpress LLC Yk-2168 | 2571068-74-9 | 98.1% | 315.80 | 1 ML
YK-2168 is a potent and selective CDK9 inhibitor (IC50 of 5.9 nM) that targets the pS2-RNA Pol II C-terminal domain. It induces apoptosis, suppresses CDK9-regulated genes like MYC and Mcl1, and inhibits tumor growth in CDX mice models. This compound is suitable for cancer research, particularly leukemia.
- Potent and selective CDK9 inhibitor (IC50 of 5.9 nM).
- Induces apoptosis and suppresses CDK9-regulated genes.
- Inhibits tumor growth in CDX mice models (80% inhibition at 10 mg/kg).
- Highly selective over CDK1 and CDK2, with no hERG channel inhibition up to 30 μM.
- Reduces pS2-RNA Pol II CTD levels and upregulates cleaved caspase 3.
- Demonstrates good safety in vivo with no significant body weight changes.
Medchemexpress LLC Sodium butane-1-sulfonate | 2386-54-1 | MFCD00007540 | 98.0% | 160.17 g/mol | C4H9NaO3S | 500 MG
Sodium butane-1-sulfonate is the sodium salt of butane-1-sulfonic acid used as an ionic mobile-phase additive for chromatographic separation of arsenic, selenium, and related analytes. It appears as a white to off-white crystalline powder, supplied for research use, and is commonly used to improve ion-pairing and retention in aqueous chromatographic methods.
- Used as ionic mobile-phase additive for chromatographic separations.
- Improves separation and resolution of arsenic and selenium species.
- High purity suitable for analytical applications (manufacturer lists ~98% assay).
- White to off-white crystalline powder; stable and easy to weigh.
- Suits ion-pairing and retention control in aqueous methods.
Medchemexpress LLC MRGPRX2 modulator-1 | 2781839-42-5 | 99.0% | 459.39 | 25 MG
MRGPRX2 modulator-1 is a mas-related g-protein receptor x2 (MRGPRX2) modulator. It can be used for the research of inflammation, pain, and autoimmune disorders.
- Purity: 99.03%
- Form: solid
- Color: white to off-white
- For research use only
- Molecular weight: 459.39
- Formula: C20H19F6N5O
Medchemexpress LLC AHL modulator-1 | 942296-18-6 | 99.2% | 298.13 | 25 MG
AHL modulator-1 is a compound that modulates N-acylated L-homoserine lactone (AHL) activity. It exhibits both agonism and antagonism in cellulase activity and potato maceration. This product is suitable for laboratory research applications.
- Soluble in DMSO
- Stable as powder at -20°C for 3 years
- Stable as powder at 4°C for 2 years
- Stable in solvent at -80°C for 6 months
- Stable in solvent at -20°C for 1 month
Medchemexpress LLC Nourseothricin sulfate | 96736-11-7 | 99.9% | 1 ML
Nourseothricin sulfate is a broad-spectrum antibiotic that works by destroying the outer membrane of Gram-negative bacteria. It also functions as a dominant selective marker for Fonsecaea pedrosoi. This antibiotic inhibits protein biosynthesis in prokaryotic cells and strongly suppresses the growth of eukaryotic organisms such as fungi.
- Broad-spectrum antibiotic
- Destroys the outer membrane of Gram-negative bacteria
- Functions as a dominant selective marker for Fonsecaea pedrosoi
- Inhibits protein biosynthesis in prokaryotic cells
- Suppresses the growth of eukaryotic organisms such as fungi
- Can be used as a selective marker for bacteria, yeast, filamentous fungi, and plant cells
Medchemexpress LLC 3',4'-Tetramethylene-α-pyrrolidinobutiophenone (hydrochloride) | 2749504-65-0 | 99.9% | 307.86 | 50 MG
3',4'-Tetramethylene-α-pyrrolidinobutiophenone hydrochloride is structurally categorized as a drug derivative.
- Applications: Neuroscience-Neuromodulation
- Research area: Neurological disease
- Target: Drug derivative
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 10MG
Mutant p53 modulator-1 is a small-molecule research reagent reported to modulate mutant p53 and to reduce progression of cancers harboring p53 mutations. It is supplied as a powder for laboratory research and includes stability instructions for storage and handling.
- High purity: 99.9% suitable for analytical and biological studies.
- Defined chemical formula: C27H32F4N8O2 for unambiguous identification.
- Documented stability: powder stable at -20°C for long-term storage.
- Reported activity against mutant p53 to support targeted cancer research.
- Intended for research use only, not for human or clinical use.
Medchemexpress LLC MicroRNA modulator-2 | 438599-31-6 | 99.5% | 432.49 g·mol⁻¹ | C23H20N4O3S | 10 MG
MicroRNA modulator-2 is an oxadiazole-class small molecule inhibitor of microRNA-21 (miR-21) with an AC50 of 16.48 μM. Supplied as a solid for research use, it is intended for in vitro miRNA inhibition studies and related cancer research. Molecular formula C23H20N4O3S; molecular weight 432.49 g·mol⁻¹.
- Oxadiazole-class small molecule inhibitor of miR-21.
- AC50 16.48 μM in reported assays.
- High purity (≈99.5%).
- Supplied as a solid; common size 10 mg.
- Suitable for in vitro cellular and biochemical miRNA studies.
- Store at -20°C; for research use only.
Medchemexpress LLC Sulindac sulfone | 59973-80-7 | 98.1% | 1 MG
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. It inhibits colon cancer cell growth and induces cell cycle arrest. It is used in cancer research.
- Inhibits mTORC1 pathway
- Metabolite of Sulindac
- Inhibits colon cancer cell growth
- Induces cell cycle arrest
- Used in cancer research
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | 99.88% | 100 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM). It selectively reduces Aβ42 production in favor of shorter Aβ species, and it can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM)
- Selectively reduces Aβ42 production in favor of shorter Aβ species
- Can be used for researching Alzheimer's disease
Apexbio Technology LLC Sulforaphane(Synonyms: Broccoli sulforaphane, DL-Sulforaphane, R-Sulforaphane, 1-Isothiocyanato-4-(methylsulfinyl)butane), 10mg, CAS: 4478-93-7.
Sulforaphane (CAS 4478-93-7) is a naturally occurring isothiocyanate abundantly found in vegetables especially broccoli It acts primarily through activation of the Keap1-Nrf2 signaling pathway enhancing cellular defense against oxidative and electrophilic stress Sulforaphane has demonstrated antiproliferative activity in vitro as shown by dose-dependent cell cycle arrest at G2/M and apoptosis induction in HT29 human colon carcinoma cells Such effects involve elevated cyclin A and B1 levels increased pro-apoptotic Bax expression mitochondrial cytochrome c release and poly(ADP-ribose) polymerase cleavage These properties make sulforaphane relevant for investigating cancer chemoprevention and cellular stress responses