Sulfoxides
Medchemexpress LLC Cytochrome P450 2E1 Antibody (YA2302) | 50 UL
Cytochrome P450 2E1 Antibody (YA2302) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2E1. It is for research use only and demonstrates endogenous sensitivity. This antibody is supplied as a liquid formulation in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol.
- Involved in fatty acid metabolism and potentially xenobiotic oxidative metabolism.
- Catalyzes hydroxylation of carbon-hydrogen bonds, specifically at the omega-1 position of saturated fatty acids.
- Subcellular localization includes endoplasmic reticulum membrane, microsome membrane, and mitochondrion inner membrane.
- Application in western blot (WB) with a dilution ratio of 1:500-1:1000.
- Species reactivity includes human, mouse, and rat.
- Immunogen is a synthesized peptide derived from human CYP2E1 aa52-114.
Medchemexpress LLC 2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG
2,4-Pentanedione, 3-pentadecylidene- | 1314006-43-3 | C20H36O2 | 25 MG
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 50 MG
CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor, with Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R, and an IC50 value of 3.4 μM for FAAH. At 10 μM, it reduces the production of pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL6 in unstimulated monocytes and macrophages. This modulator can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
- Molecular weight: 341.49
- Formula: C22H31NO2
- CAS no.: 2876918-67-9
- Appearance: Solid
- Color: White to off-white
- Purity: 99.71%
Medchemexpress LLC Cytochrome P450 2C9 Antibody (YA2166) | 100 UL
Cytochrome P450 2C9 Antibody (YA2166) is a Rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 2C9. It is for research use only and is involved in the metabolism of various endogenous substrates, including fatty acids and steroids, contributing to the pharmacokinetic variability of drugs.
- Host: Rabbit
- Clonality: Recombinant, monoclonal
- Species reactivity: Human
- Conjugation: Non-conjugated
- Isotype: IgG
- Formulation: Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles
- Shipping: Shipping with blue ice
- Application & dilution ratio: WB: 1:500-1:1000; ICC/IF: 1:50-1:200; FC: 1:50-1:100
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 1 ML
CB2R/FAAH modulator-3 is a dual-targeting modulator that functions as a Cannabinoid receptor 2 (CB2R) agonist and a Fatty Acid Amide Hydrolase (FAAH) inhibitor. This modulator demonstrates a high affinity for CB2R with a Ki value of 20.1 nM, and a lower affinity for CB1R with a Ki value of 67.6 nM. It inhibits FAAH with an IC50 value of 3.4 μM. In in vitro studies, at a concentration of 10 μM, it has been shown to reduce the production of pro-inflammatory cytokines, including TNFα, IFN-γ, IL-1β, and IL6, in unstimulated monocytes and macrophages.
- Suitable for use in research related to various conditions, such as cancer.
- Suitable for use in research related to inflammatory cascades associated with neurodegenerative diseases.
- Suitable for use in research related to COVID-19 infection.
Cayman Chemical GlycerophosphoNPalmitoyl Etha
Precursor of PEA, an endogenous CB found in brain, liver, and other mammalian tissues; PEA has potent anti-inflammatory activity in vivo
