Sulfoxides
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 87.3% | 250 MG
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and strongly suppresses the growth of eukaryotes. It targets the outer membrane of Gram-negative bacteria and serves as a selective marker for various organisms, including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Targets outer membrane of Gram-negative bacteria
- Serves as a selective marker for Fonsecaea pedrosoi
- Inhibits protein biosynthesis in prokaryotic cells
- Strongly suppresses growth of eukaryotes, such as fungi
- Sensitizes resistant Escherichia coli strains by eliminating outer membrane resistance
- Mixture of several Streptothricins (primarily D and F)
- Can create channels in the outer membrane
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | MFCD00869764 | 99.88% | 250 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. It can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM).
- Selectively reduces Aβ42 production.
- Useful for Alzheimer's disease research.
Medchemexpress LLC GLP-1R modulator C5 | 421578-93-0 | 99.8% | C24H21NO3 | 100 MG
GLP-1R modulator C5 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). It is intended for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Suitable for research applications
- Targets glucagon receptor (GCGR)
- Relevant for inflammation or immune system disease research
- Relevant for metabolic or endocrine disease research
- Relevant for digestive system disease research
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.05% | 315.80 | 50 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits the phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. This product can be used for cancer research, including leukemia.
- Potently inhibits purified CDK9 enzymatic activity
- Exhibits high selectivity over CDK1 and CDK2
- Inhibits proliferation of MV4-11 leukemia cells
- Induces dose-dependent inhibition of tumor growth in CDX mice models
- Suppresses CDK9-regulated gene expression
- Upregulates cleaved caspase 3, indicating induced apoptosis
- Maintains a good safety profile in vivo with no significant body weight changes
Medchemexpress LLC 3',4'-Tetramethylene-α-pyrrolidinobutiophenone (hydrochloride) | 2749504-65-0 | 99.9% | 307.86 | 50 MG
3',4'-Tetramethylene-α-pyrrolidinobutiophenone (hydrochloride) | 2749504-65-0 | 99.9% | 307.86 | 50 MG
Medchemexpress LLC Kv3.1 modulator 2 | 3035827-42-7 | 99.8% | 437.88 | 25 MG
Kv3.1 modulator 2 is a Kv3.1 channels modulator with an EC50 value of 68 nM. It is for research use only and not sold to patients. This compound is a solid, appearing white to off-white, and has detailed storage and solubility protocols for various applications.
- Kv3.1 channels modulator
- EC50 value of 68 nM
- Solid, white to off-white appearance
- Specific storage recommendations for powder and in solvent
- Detailed solubility information for in vitro and in vivo use
![Medchemexpress LLC 1-(2-(dimethylamino)ethyl)-3-(7-methylbenzo[1,2-d:3,4-d']bis(thiazole)-2-yl)urea | 1428729-63-8 | MFCD31619259 | 99.5% | 335.45 | C14H17N5OS2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242667.png-250.jpg)
Medchemexpress LLC 1-(2-(dimethylamino)ethyl)-3-(7-methylbenzo[1,2-d:3,4-d']bis(thiazole)-2-yl)urea | 1428729-63-8 | MFCD31619259 | 99.5% | 335.45 | C14H17N5OS2 | 100 MG
RIG-1 modulator 1 is a small-molecule antiviral research compound described as "Compound of claim 13" that modulates RIG-1-related activity and is reported active against influenza virus, HBV, HCV, and HIV. It is supplied as a characterized solid for in vitro research and includes storage and stability information for powder and solutions.
- High purity: 99.5%.
- Appearance: solid, white to light yellow.
- Molecular formula: C14H17N5OS2; molecular weight: 335.45.
- Available in multiple pack sizes, including 100 mg.
- Storage recommendations: powder -20 °C (up to 3 years) or 4 °C (up to 2 years); in solvent -80 °C (up to 2 years).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Triclabendazole sulfoxide | 100648-13-3 | 98.8% | 375.66 | 100 MG
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole. It exhibits anti-parasite effects and can inhibit the membrane transporter ABCG2/BCRP.
- Main plasma metabolite of Triclabendazole.
- Exhibits anti-parasite effects.
- Inhibits membrane transporter ABCG2/BCRP.
- Targets parasite, BCRP, and PDGFR.
- Involved in anti-infection, membrane transporter/ion channel, and protein tyrosine kinase/RTK pathways.
Medchemexpress LLC Elafibranor sulfoxide | 95.0% | 400.49 | C22H24O5S | 10 MG
Elafibranor sulfoxide is the sulfoxide metabolite of elafibranor supplied as a research-grade powder for in vitro and preclinical studies. It is intended for laboratory research use only and can be used to investigate PPAR-related pathways and metabolic disease models such as primary biliary cholangitis.
- Chemical formula C22H24O5S, molecular weight 400.49.
- Supplied as a powder; pack sizes include 10 MG.
- Purity (NMR): 95.0%.
- Target: PPAR; drug metabolite.
- Storage: powder -20°C for 3 years, 4°C for 2 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Provided for research use only; not for human therapeutic use.
Medchemexpress LLC GPR120 modulator 2 | 1050506-87-0 | 97.1% | C20H18CINO3S | 50 MG
GPR120 modulator 2 | 1050506-87-0 | 97.1% | C20H18CINO3S | 50 MG
Alkali Scientific Novobiocin Sodium Salt, 100 Grams
Novobiocin Sodium Salt is an antibiotic used to inhibit bacterial growth, especially for the isolation of Gram-positive bacteria. This 100g powder formulation is a valuable tool for laboratory research, where it is primarily used to study bacterial resistance mechanisms and to control bacterial contamination in culture media. Novobiocin inhibits DNA gyrase, an essential enzyme in bacterial replication, making it effective for selective bacterial inhibition. Laboratories use this antibiotic for a variety of microbial assays, including testing bacterial susceptibility and studying the biochemical properties of different bacterial strains.
Medchemexpress LLC IL-17A modulator-3 | 2467732-95-0 | 99.37% | 639.80 | 5 MG
IL-17A modulator-3 (compound 253) is an IL-17A modulator. It inhibits IL-17A/A with an IC50 value of <10 μM. It can be used for the research of inflammation, cancer, and autoimmune diseases.
- Can be used for the research of inflammation
- Can be used for the research of cancer
- Can be used for the research of autoimmune diseases
FOCUS BIOMOLECULES Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms)
Biochemical Reagents, UHMCP1, Spliceosome modulator, CAS Unknown, 97% by HPLC/NMR (Conforms), UHMCP1 prevents the interaction (KD 80 uM) between the splicing factor SF3b155 and U2AF homology motif domain (UHM) U2AF65.1 The spliceosomal gene SF3B1 (which encodes for SF3b155) is frequently mutated in cancers as is the splicing factor U2AF.2 UHMCP1 displaying toxicity against HEK293 cells (EC50 140 uM) and various effects on pre-mRNA accumulation or intron retention, exon skipping and inclusion.1 An interesting new tool for study of the spliceosome.
Medchemexpress LLC Sulindac sulfone | 59973-80-7 | 98.1% | 1 MG
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. It inhibits colon cancer cell growth and induces cell cycle arrest. It is used in cancer research.
- Inhibits mTORC1 pathway
- Metabolite of Sulindac
- Inhibits colon cancer cell growth
- Induces cell cycle arrest
- Used in cancer research
Medchemexpress LLC Iduronate 2-sulfatase protein, human | 50936-59-9 | >95.0% | 1 MG
Recombinant human iduronate 2-sulfatase (IDS) is a lysosomal enzyme produced in HEK293 cells and supplied lyophilized for research use. It participates in the degradation of dermatan sulfate and heparan sulfate, and is suitable for biochemical assays and enzyme activity studies.
- Expression system: HEK293 cells
- Tag: C-terminal His
- Purity: >95.0% by reducing SDS-PAGE
- Molecular weight: ~75-95 kDa (glycosylated)
- Formulation: lyophilized from 0.22 μm filtered PBS, pH 7.4
- Storage: store lyophilized at -20°C; aliquot and freeze at -80°C for long term
- Activity: specific activity ~6.123 pmoL/min/μg