Sulfoxides
TARGETMOL CHEMICALS INC IL-17 MODULATOR 4 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. IL-17 modulator 4 is a prodrug of IL-17 modulator 1 which is an efficacious modulator of IL-17. purity: 98%
AdipoGen Prosulfocarb sulfoxide
Chemical. CAS 51954-81-5. Formula C14H21NO2S. MW 267.39. Metabolite of the herbicide Prosulfocarb. Can be used as a reference compound.
Medchemexpress LLC N'-(3-acetylphenyl)-N-(3-(2-methoxyethyl)-2,4-dioxo-1-(2-(piperidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinazolin | 2946701-09-1 | 99.3% | 507.58 g/mol | C27H33N5O5 | 10 MG
COP1-ATGL modulator 1 is an orally active small-molecule research reagent that modulates the COP1-ATGL pathway. It increases ATGL protein expression, reduces ATGL and COP1 ubiquitination, and diminishes lipid accumulation in hepatocytes at nanomolar concentrations. Supplied as a white to off-white solid with high purity and defined storage recommendations for powder and solution.
- Orally active modulator of COP1-ATGL signaling.
- Increases ATGL protein expression at nanomolar concentrations.
- Reduces ATGL and COP1 ubiquitination in cellular assays.
- High purity suitable for research applications.
- Stable solid with recommended low-temperature storage.
Medchemexpress LLC Hydrazinecarbothioamide, 2-(1H-indol-3-ylmethylene)-N-(4-methylphenyl)-, (2E)- | 2097787-75-0 | 99.0% | 308.40 g/mol | C17H16N4S | 10 MG
Nur77 modulator 3 is a small-molecule research compound that binds nuclear receptor Nur77 (NR4A1) and modulates its activity. It has been reported to inhibit TGF-β1-induced α-SMA and COLA1 expression and to reduce hepatic stellate cell activation and extracellular matrix deposition. Technical identifiers include CAS 2097787-75-0, formula C17H16N4S, molecular weight 308.40 g/mol, and purity 99.01%.
- Modulates Nur77 activity in cellular and in vivo models.
- Inhibits TGF-β1-induced α-SMA and COLA1 expression.
- High purity (99.01%) suitable for biochemical and cell-based assays.
- Supplied in small quantities appropriate for assay development and pilot studies.
Medchemexpress LLC A1AT modulator 1 | 2406205-61-4 | 99.8% | 370.42 | C21H23FN2O3 | 5 MG
A1AT modulator 1 is a research-grade small molecule inhibitor used to study Z α1-antitrypsin polymerization and related biochemical pathways. The compound is a solid (white to off-white) with molecular formula C21H23FN2O3 and molecular weight 370.42. It is provided for laboratory research use with storage recommendations for both powder and solution to maintain stability.
- Potent inhibitor of Z α1-antitrypsin polymerization (pIC50 = 8.3).
- High analytical purity (99.77%).
- Solid, white to off-white appearance suitable for handling in lab settings.
- Stable when stored under recommended conditions (powder: -20°C or 4°C; in solvent: -80°C or -20°C).
- Provided in small-quantity packaging appropriate for research assays.
Apexbio Technology LLC Sulindac sulfone 59864-04-9 5mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation