Sulfoxides
Medchemexpress LLC Tnfa Activ Modulator 3 Reconst | HY-160412-1MM/1ML RECONST
Tnfa Activ Modulator 3 Reconst
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | MFCD00869764 | 99.88% | 250 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. It can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM).
- Selectively reduces Aβ42 production.
- Useful for Alzheimer's disease research.
Medchemexpress LLC Sulindac sulfide | 49627-27-2 | 98.1% | 100 MG
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity. For research use only. MedChemExpress does not sell to patients.
- Solubility in vitro: DMSO at 50 mg/mL (146.88 mM), requires ultrasonic assistance, use newly opened DMSO due to hygroscopic nature.
- Stock solution storage: -80°C for 6 months; -20°C for 1 month.
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage of powder: -20°C for 3 years; in solvent: -80°C for 6 months, -20°C for 1 month.
Apexbio Technology LLC Sulindac 38194-50-2 100mg
Sulindac (CAS 38194-50-2) is a nonsteroidal anti-inflammatory drug that functions as a prodrug and is metabolized in vivo to pharmacologically active sulindac sulfide and sulindac sulfone Sulindac sulfide acts as a cyclooxygenase inhibitor and modulates intracellular signaling pathways including the repression of ras activity Sulindac sulfone possesses antitumor properties independent of cyclooxygenase inhibition Due to these distinct metabolites and their activities sulindac is utilized in biomedical research for studying inflammatory processes cyclooxygenase-mediated pathways and the chemopreventive mechanisms involved in tumorigenesis
eMolecules 67-68-5 | Dimethyl sulfoxide | Combi-Blocks, Inc. | MFCD00002089 | 78.130 | C2H6OS | 95.000 | CS(C)=O | 500g | 642100602
Dimethyl sulfoxide | Combi-Blocks, Inc. | 67-68-5 | MFCD00002089 | 78.130 | C2H6OS | 95.000 | CS(C)=O | 500g | 642100602
TARGETMOL CHEMICALS INC Sulindac sulfone 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes.Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM). Purity 98.19%
eMolecules 67-68-5 | Dimethyl Sulfoxide | AA Blocks LLC | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 25g | 598385588
Dimethyl Sulfoxide | AA Blocks LLC | 67-68-5 | MFCD00002089 | 78.130 | C2H6OS | 0.000 | CS(C)=O | 25g | 598385588
Apexbio Technology LLC Sulindac sulfone 59864-04-9 5mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation
Apexbio Technology LLC Sulindac 38194-50-2 1g
Sulindac (CAS 38194-50-2) is a nonsteroidal anti-inflammatory drug that functions as a prodrug and is metabolized in vivo to pharmacologically active sulindac sulfide and sulindac sulfone Sulindac sulfide acts as a cyclooxygenase inhibitor and modulates intracellular signaling pathways including the repression of ras activity Sulindac sulfone possesses antitumor properties independent of cyclooxygenase inhibition Due to these distinct metabolites and their activities sulindac is utilized in biomedical research for studying inflammatory processes cyclooxygenase-mediated pathways and the chemopreventive mechanisms involved in tumorigenesis