Sulfoxides
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 87.3% | 250 MG
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and strongly suppresses the growth of eukaryotes. It targets the outer membrane of Gram-negative bacteria and serves as a selective marker for various organisms, including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Targets outer membrane of Gram-negative bacteria
- Serves as a selective marker for Fonsecaea pedrosoi
- Inhibits protein biosynthesis in prokaryotic cells
- Strongly suppresses growth of eukaryotes, such as fungi
- Sensitizes resistant Escherichia coli strains by eliminating outer membrane resistance
- Mixture of several Streptothricins (primarily D and F)
- Can create channels in the outer membrane
AdipoGen GS-441524 Remdesivir Metabol
Chemical. CAS 1191237-69-0. Formula C12H13N5O4. MW 291.3. GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases RdRps. The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease ExoN, causing a decrease in viral RNA production RNA synthesis arrest, either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures EC50=74nM and 69nM and murine hepatitis virus MHV EC50=30nM. In vivo, remdesivir 25 and 50 mg/kg reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection.
Medchemexpress LLC Nourseothricin sulfate (streptothricin sulfate) | 96736-11-7 | 99.9% | 100 MG
Nourseothricin sulfate (Streptothricin sulfate) is a broad-spectrum antibiotic that destroys the outer membrane of Gram-negative bacteria and is a dominant selective marker for Fonsecaea pedrosoi. It inhibits protein biosynthesis in prokaryotic cells and strongly inhibits the growth of eukaryotes like fungi, and can also be used as a selective marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Destroys the outer membrane of Gram-negative bacteria
- Dominant selective marker for Fonsecaea pedrosoi
- Inhibits protein biosynthesis in prokaryotic cells
- Strongly inhibits the growth of eukaryotes like fungi
- Can be used as a selective marker for bacteria, yeast, filamentous fungi, and plant cells
Medchemexpress LLC Sulindac sulfone | 59973-80-7 | 98.1% | 5 MG
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. It inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is utilized in cancer research.
- Cytotoxicity against human COLO320 cells after 72 hrs by WST-1 assay (IC50 > 200 μM)
- Cytotoxicity against human MIAPaCa2 cells after 72 hrs by WST-1 assay (IC50 > 200 μM)
Medchemexpress LLC Hydrazinecarbothioamide, 2-(1H-indol-3-ylmethylene)-N-(4-methylphenyl)-, (2E)- | 2097787-75-0 | 99.0% | 308.40 g/mol | C17H16N4S | 10 MG
Nur77 modulator 3 is a small-molecule research compound that binds nuclear receptor Nur77 (NR4A1) and modulates its activity. It has been reported to inhibit TGF-β1-induced α-SMA and COLA1 expression and to reduce hepatic stellate cell activation and extracellular matrix deposition. Technical identifiers include CAS 2097787-75-0, formula C17H16N4S, molecular weight 308.40 g/mol, and purity 99.01%.
- Modulates Nur77 activity in cellular and in vivo models.
- Inhibits TGF-β1-induced α-SMA and COLA1 expression.
- High purity (99.01%) suitable for biochemical and cell-based assays.
- Supplied in small quantities appropriate for assay development and pilot studies.
Medchemexpress LLC Il-17 modulator 1 disodium | 2446803-91-2 | 98.4% | C28H35N6Na2O6P | 1 ML
IL-17 modulator 1 disodium is an orally active, highly efficacious small molecule IL-17 modulator. Extracted from patent WO 2020127685, this salt form offers enhanced water solubility and stability compared to its free form. It is suitable for research aimed at preventing or ameliorating diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis. This product is for research use only.
- Orally active and highly efficacious
- Small molecule IL-17 modulator
- Enhanced water solubility and stability in disodium salt form
- Useful for research into psoriasis, ankylosing spondylitis, and psoriatic arthritis
- White to off-white solid appearance
TARGETMOL CHEMICALS INC TETRABENAZINE METABOLITE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Tetrabenazine Metabolite ((-)-(beta)-HTBZ) a vesicles monoamine transporter 2 (VMAT2) inhibitor is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetrabenazine Metabolite is often used to study chorea associated with Huntington's disease and other hyperactivity disorders. purity: 95%
Medchemexpress LLC GLP-1R modulator L7-028 | 2648317-95-5 | 99.47% | C24H28N2O3 | 100 MG
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM). It is intended for research use only.
- Available as a solid, white to off-white in color.
- Soluble in DMSO at 100 mg/mL.
- Shipped at room temperature in continental US.
AdipoGen Prosulfocarb sulfoxide
Chemical. CAS 51954-81-5. Formula C14H21NO2S. MW 267.39. Metabolite of the herbicide Prosulfocarb. Can be used as a reference compound.
AdipoGen Prosulfocarb sulfoxide
Chemical. CAS 51954-81-5. Formula C14H21NO2S. MW 267.39. Metabolite of the herbicide Prosulfocarb. Can be used as a reference compound.
Medchemexpress LLC Quetiapine sulfoxide dihydrochloride | 329218-11-3 | MFCD09031385 | 98.6% | 472.43 g·mol-1 | C21H27Cl2N3O3S | 10 MG
Quetiapine sulfoxide dihydrochloride is the dihydrochloride salt of quetiapine sulfoxide, a primary metabolite of the antipsychotic quetiapine. It is provided as a research-grade biochemical reference for analytical, metabolic, and pharmacokinetic studies.
- Main metabolite of quetiapine used in metabolism research and metabolite identification.
- Provided as a stable dihydrochloride salt to improve solubility and handling.
- High purity suitable for analytical and reference-standard applications.
- Available in small milligram pack sizes and as a 10 mM solution for assay preparation.