Sulfoxides
Medchemexpress LLC IL-17 modulator 4 | 2446803-65-0 | >99.0% | C27H34N6O2 | 1 ML
IL-17 modulator 4 is a proagent of IL-17 modulator 1, active against IL-17A mediated diseases. This orally active modulator shows promise for the research of conditions including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. It inhibits IL-17A-mediated signaling pathways by stabilizing the IL-17A dimer and preventing its binding to the IL-17RA receptor.
- Modulates IL-17A protein-protein interaction
- Stabilizes IL-17A dimer conformation
- Prevents IL-17A from binding to IL-17RA receptor
- Inhibits IL-17A-mediated signaling pathways
- Exhibits good pharmacokinetic properties in rat models
- Oral bioavailability of 100% in rat models
Medchemexpress LLC (+)-LRH-1 modulator-1 | 2244781-29-9 | 99.38% | 464.66 | 50 MG
(+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1, a potent LRH-1 (liver receptor homolog-1) modulator/agonist. It exhibits anti-inflammatory effects in intestinal organoids by inducing the anti-inflammatory cytokine IL-10 and reducing the inflammatory cytokines IL-1b and TNFa.
- Potent LRH-1 modulator/agonist
- Exhibits anti-inflammatory effects in intestinal organoids
- Induces anti-inflammatory cytokine IL-10
- Reduces inflammatory cytokines IL-1b and TNFa
- Pure form storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Shipping conditions: Room temperature if less than 2 weeks
Medchemexpress LLC Ritonavir metabolite (Desthiazolylmethyloxycarbonyl Ritonavir) | 176655-55-3 | 99.6% | 579.80 | 5 MG
Ritonavir metabolite is a metabolite of Ritonavir, which is an HIV protease inhibitor. The product appears as a white to off-white solid.
- Purity of 99.6%
- Molecular weight of 579.80
- CAS number 176655-55-3
- Storage at -20°C for powder, -80°C for 6 months in solvent
- Shipping at room temperature in continental US
Medchemexpress LLC Cytochrome P450 17A1 Antibody (YA478) | 57 kDa | 10 UL
This Cytochrome P450 17A1 Antibody (YA478) is supplied as a liquid and is suitable for various laboratory applications. It is stable under recommended storage conditions and intended for research use only.
- Host: Rabbit
- Reactivity: Human, mouse, rat
- Clonality number: YA478
- SwissProt ID: P05093
- Gene ID: 1586
- Appearance: Liquid
- Concentration: 1.0 mg/mL
- Conjugation: Non-conjugated
- Application: WB, ICC/IF, IHC-P, FC
- Dilution ratio: WB: 1:500; ICC/IF: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:100
- Formulation: Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles.
- Shipping: Shipping with blue ice.
- Molecular weight: 57 kDa
TARGETMOL CHEMICALS INC NOT Receptor Modulator 1 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.NOT Receptor Modulator 1 (2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol) is a modulator of nuclear receptor NOT. Purity 97.01%
Medchemexpress LLC Cytochrome P450 1B1 antibody (YA1836) | 10 UL
Cytochrome P450 1B1 antibody (YA1836) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 1B1. It is intended for research use only.
- Rabbit host
- Recombinant, monoclonal
- Species reactivity: Human, mouse, rat
- Immunogen: A synthesized peptide derived from human CYP1B1 aa400-543
- Isotype: IgG
- Appearance: Liquid
- Formulation: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- Storage & stability: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles
- Shipping: Shipping with blue ice
- Applications & dilution ratios: WB (Western Blot): 1:500-1:1000, IHC-P (Immunohistochemistry-Paraffin): 1:50-1:100, FC (Flow Cytometry): 1:50-1:100
- Sensitivity: Endogenous
- Conjugation: Non-conjugated
- Modification: Unmodified
Medchemexpress LLC Cytochrome P450 24A1 Antibody (YA2121) | 50 UL
Cytochrome P450 24A1 Antibody (YA2121) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically targeting Cytochrome P450 24A1. This antibody is intended for research use only. Cytochrome P450 24A1 is a monooxygenase crucial for vitamin D catabolism and calcium homeostasis, inactivating calcidiol and calcitriol via C24- and C23-oxidation pathways.
- Host: Rabbit
- Clonality: Monoclonal
- Conjugation: Non-conjugated
- Isotype: IgG
- Appearance: Liquid
- Purity: Affinity chromatography
- Application: Western blot (WB)
- Dilution ratio: 1:500-1:1000
- Species reactivity: Human
- Molecular weight: 59 kDa (predicted and observed)
- Subcellular localization: Mitochondrion
- Research field: Cardiovascular
Medchemexpress LLC KAT modulator-1 | 1314006-43-3 | C20H36O2 | 50 MG
KAT modulator-1 is a laboratory chemical identified for research use only. It has a molecular formula of C20H36O2 and a molecular weight of 308.50. This substance appears as a solid and is considered stable under recommended storage conditions, though it has not been fully validated for medical applications.
- Not classified as a hazardous substance
- Stable under recommended storage conditions
- Store in a tightly sealed container in a cool, well-ventilated area
- Avoid direct sunlight and ignition sources
- Recommended powder storage: -20°C for 3 years, 4°C for 2 years
- Recommended in-solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Sulforaphane | 4478-93-7 | 99.75% | 177.29 | 200 MG
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. It promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. It protects the heart through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission and exhibits both anticancer and anti-inflammatory properties.
- Targets: HDAC, Keap1-Nrf2, Apoptosis, Bcl-2 family, Caspase, Reactive oxygen species (ROS)
- Research areas: Inflammation/Immunology, Cancer
Sigma Aldrich Fine Chemicals Biosciences Cytochrome P450 3A4 human
Supplied as purified soluble proteins rather than microsomal preparations.
TARGETMOL CHEMICALS INC GPR40/FFAR1 MODULATOR 1 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. purity: 99%
Medchemexpress LLC Nourseothricin sulfate | 96736-11-7 | 99.9% | 25 MG
Nourseothricin sulfate is a broad-spectrum antibiotic that targets the outer membrane of Gram-negative bacteria. It inhibits protein biosynthesis in prokaryotic cells and suppresses the growth of eukaryotes like fungi. It can also be utilized as a selective marker for a wide array of organisms.
- Broad-spectrum antibiotic
- Targets outer membrane of Gram-negative bacteria
- Serves as a dominant selective marker for *Fonsecaea pedrosoi*
- Inhibits protein biosynthesis in prokaryotic cells
- Suppresses the growth of eukaryotes like fungi
- Can be used as a selective marker for various organisms, including bacteria, yeast, filamentous fungi, and plant cells
Medchemexpress LLC Iduronate 2-sulfatase, recombinant human (His-tag) | 50936-59-9 | >95.0% | 5 UG
Recombinant human iduronate 2-sulfatase (IDS) produced in HEK293 cells and provided as a lyophilized, C-terminal His-tagged protein for research applications. The glycosylated enzyme is highly pure and supplied with low endotoxin; enzymatic activity is reported by manufacturer assay. Follow storage and reconstitution instructions for optimal stability.
- Expressed in HEK293 cells
- C-terminal His tag for purification and detection
- Purity >95.0% by reducing SDS-PAGE
- Endotoxin <1 EU/μg
- Specific activity ~6.1 pmoL/min/μg
- Lyophilized formulation; reconstitute per instructions
- Store frozen; aliquot to avoid freeze-thaw
Apexbio Technology LLC Sulindac sulfone 59864-04-9 5mg
Sulindac sulfone (CAS 59864-04-9) is a metabolite of the NSAID sulindac and has been investigated for its effects on colorectal cancer models It modulates cellular signaling by decreasing -catenin pro-caspase 3 cyclin D1 and PPAR levels in SW480 cells and reduces TCF-mediated transcription in a dose-dependent manner In vitro sulindac sulfone inhibits PGE2 production in HCA-7 cells (IC50 360 mmol/L) and decreases colony formation in HCA-7 and HCT-116 cells (EC50 50 mmol/L) In vivo it lowers tumor incidence in the AOM-induced colorectal cancer rat model Clinically it has led to regression of rectal polyps in familial adenomatous polyposis patients Sulindac sulfone is utilized in research focused on colorectal cancer chemoprevention and -catenin pathway modulation