Thioureas
AdipoGen Z-Phe-Arg-AFC
Chemical. CAS 93753-73-2 free base. Formula C33H33F3N6O6 . C2HF3O2. MW 666.7 . 114.0. Synthetic. Fluorogenic substrate, specifically used to determine the enzyme activity of Cathepsin L. Useful for the study of cathepsin activity and for screening small molecule inhibitors for drug discovery and HTS applications. Likely to be cleaved by cathepsins B, F, K, S and L, cathepsins L-like proteases and proteases such as papain, cruzipain, plasma kallikrein, soybean trypsin-like enzyme and the falcipains-1 and -2 malaria hemoglobinases. Hydrolysis of this substrate is monitored by observing fluorescence at an Excitation of 400nm and Emission at 505nm.
AdipoGen Z-Leu-Leu-Glu-AMC
Chemical. CAS 348086-66-8. Formula C35H44N4O9. MW 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing PGPH caspase-like activity of the 20S proteasome. Excitation 380nm. Emission 460nm.
AdipoGen Z-Leu-Leu-Glu-AMC
Chemical. CAS 348086-66-8. Formula C35H44N4O9. MW 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing PGPH caspase-like activity of the 20S proteasome. Excitation 380nm. Emission 460nm.
AdipoGen Boc-AspOMe-FMK
Chemical. CAS 187389-53-3. Formula C11H18FNO5. MW 263.3. Synthetic. Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha IC50=39µM. Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
AdipoGen Z-Leu-Leu-Leu-BOH2 MG-262
Chemical. CAS 179324-22-2. Formula C25H42BN3O6. MW 491.4. Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Similar structure as MG-132 AG-CP3-0011 but much higher potency.
AdipoGen Necrostatin-5 Nec-5
Chemical. CAS 337349-54-9. Formula C19H17N3O2S2. MW 383.5. Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective
AdipoGen Boc-AspOMe-FMK
Chemical. CAS 187389-53-3. Formula C11H18FNO5. MW 263.3. Synthetic. Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha IC50=39µM. Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
AdipoGen Indole-3-carbinol
Chemical. CAS 700-06-1. Formula C9H9NO. MW 147.2. Natural breakdown product of glucosinolates found in cruciferous vegetables. Widely used multifunctional aryl hydrocarbon receptor AhR agonist. AhR is emerging as a transcription factor involved in the regulation of both innate and adaptive immune responses in various immune cell types, including lymphocytes and antigen-presenting cells APCs. Studies have associated overexpression of AHR with the activation of cancer processes such as proliferation, epithelial-to-mesenchymal transition EMT, DNA damage, inflammation, migration and angiogenesis. Used to increase the population of innate lymphoid cells 3 ILC3 in gut microbiota. Chemopreventive agent that has multiple anticarcinogenic and antitumor properties and suppresses the proliferation of selective cancer cells, including breast cancer, prostate cancer, endometrial cancer, colon cancer and leukemic cells. Protects against nephrotoxicity. Proapoptotic.
AdipoGen CTPB
Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
AdipoGen Q-VD-OPh
Chemical. CAS 1135695-98-5 anhydrous. Formula C26H25F2N3O6. MW 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl OPh group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
eMolecules Chem-Impex Thiourea 1kg 386903162 30059 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
Chem-Impex Thiourea 1kg 386903162 30059 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
eMolecules 1-Hexyl-3-phenyl-2-thiourea | 15153-13-6 | MFCD00060425 | 1g
Oakwood Chemical | 1-Hexyl-3-phenyl-2-thiourea | 1g | 537677239 | 018708 | | 15153-13-6 | MFCD00060425 | 236.380 | C13H20N2S
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eMolecules Chem-Impex Thiourea 5kg 386903164 30059 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
Chem-Impex Thiourea 5kg 386903164 30059 0 000 62-56-6 MFCD00008067 76 120 CH4N2S