Thioureas
AdipoGen Efavirenz
Chemical. CAS 154598-52-4. Formula C14H9ClF3NO2. MW 315.7. Efavirenz is a non-nucleoside reverse transcriptase inhibitor NNRTI that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs Ki= 2.93nM and 3.85-56.5nM, respectively. It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells IC95s = 1.5-1,500 nM. Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17nM. Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDS treatment. It is part of highly active antiretroviral therapy HAART for the treatment of a human immunodeficiency virus HIV type 1. In various cancer cell lines, Efavirenz inhibits cellular proliferation and increases activation of p53. CARD8 inflammasome senses HIV-1 protease activity. In HIV1-infected cells, CARD8 cannot detect the virus because the viral protease remains inactive as a subunit of unprocessed Gag-Pol polyprotein.
eMolecules 62-56-6 | Thiourea | Chem-Impex | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 250g | 449074787
Thiourea | Chem-Impex | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 250g | 449074787
eMolecules 62-56-6 | Thiourea ACS Reagent Grade | Oakwood Chemicals | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5g | 480154134
Thiourea ACS Reagent Grade | Oakwood Chemicals | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5g | 480154134
eMolecules 62-56-6 | Thiourea ACS Reagent Grade | Oakwood Chemicals | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 1g | 480154133
Thiourea ACS Reagent Grade | Oakwood Chemicals | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 1g | 480154133
eMolecules 62-56-6 | Thiourea | Combi-Blocks | MFCD00008067 | 76.120 | CH4N2S | 98.000 | NC(N)=S | 500g | 335351078
Thiourea | Combi-Blocks | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 98.000 | NC(N)=S | 500g | 335351078
AdipoGen L-Alanyl-L-glutamine
Chemical. CAS 39537-23-0. Formula C8H15N3O4. MW 217.22. Synthetic. L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine Ala-Gln and Gylcyl-L-glutamine Gly-Gln are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant peroxide and anti-apoptosis LPS-induced factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy.
AdipoGen Zoxamide
Chemical. CAS 156052-68-5. Formula C14H16Cl3NO2. MW 336.6. Synthetic. Fungicide. Primarily an oomycete fungicide although it has some activity against ascomycetes and basidiomycetes. The product acts by disruption of the microtubule structure and inhibition of cell division. The mechanism for this activity is through the covalent binding of the active ingredient to beta-tubulin in the cytoskeleton. Scanning microscopy studies showed zoxamide action against blight on potato crops begins after germination, achieving inhibition of hyphal development and sporangia production. This novel mode of action makes zoxamide an important new tool in antiresistance strategies. Can be used as a reference compound.
AdipoGen Colcemid
Chemical. CAS 477-30-5. Formula C21H25NO5. MW 371.4. Semisynthetic from colchicine Prod. No. AG-CN2-0048. Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation inactivates spindle fibre formation. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.
AdipoGen Boc-Leu-Arg-Arg-AMC
Chemical. CAS 109358-46-5 free base. Formula C33H52N10O7 . C2H4O2. MW 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues R and K. Excitation 380nm. Emission 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen MnTBAP chloride
Chemical. CAS 55266-18-7. Formula C48H28MnN4O8Cl. MW 879.2. Cell permeable superoxide dismutase SOD mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions peroxynitrite scavenger, but not a scavenger of nitric oxide NO. Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK. .
AdipoGen MS-275
Chemical. CAS 209783-80-2. Formula C21H20N4O3. MW 376.4. HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.
AdipoGen Z-Leu-Leu-Nva-CHO MG-115
Chemical. CAS 133407-86-0. Formula C25H39N3O5. MW 461.6. Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.
AdipoGen 1-Azakenpaullone
Chemical. CAS 676596-65-9. Formula C15H10BrN3O. MW 328.2. Potent and ATP-competitive GSK-3beta glycogen synthase kinase-3beta inhibitor IC50 = 18 nM.
AdipoGen Q-VD-OPh
Chemical. CAS 1135695-98-5 anhydrous. Formula C26H25F2N3O6. MW 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl OPh group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
AdipoGen Z-Leu-Leu-Phe-CHO
Chemical. CAS 133429-58-0. Formula C29H39N3O5. MW 509.7. Reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC.