Thioureas
Sigma Organic Chemistry Thiourea | 5KG | 62-56-6 | MFCD00008067
Thiourea, 5KG
About This Item:
Storage: room temp
EINECS Number: 200-543-5
Sigma Organic Chemistry Thiourea | 100G | 62-56-6 | MFCD00008067
Thiourea, 100G
About This Item:
Storage: room temp
EINECS Number: 200-543-5
Sigma Organic Chemistry Thiourea | 50G | 62-56-6 | MFCD00008067
Thiourea, 50G
About This Item:
Storage: room temp
EINECS Number: 200-543-5
AdipoGen Vandetanib
Chemical. CAS 443913-73-3. Formula C22H24BrFN4O2. MW 475.4. Vandetanib is an orally available, ATP mimetic small molecule tyrosine kinases inhibitor that targets vascular endothelial growth factor receptor-2 VEGFR-2, VEGFR-3 and epidermal growth factor receptor EGFR, REarranged during Transfection RET and slightly VEGFR-1. Inhibition of these tyrosine kinases blocks multiple intracellular signaling pathways involved in tumor growth, proliferation, progression and angiogenesis. It inhibits RET, VEGFR2, VEGFR3, VEGFR1, EGFR, PDGFRbeta, Tie-2, and FGFR1 in cell-free assays IC50s = 34, 40, 110, 1,600, 500, 1,100, 2,500, and 3,600 nM, respectively. It also binds to 142 additional kinases in a panel of 442 kinases Kds = 4.6-7,900 nM. Vandetanib 1 and 2.5 µM induces apoptosis, autophagy, ROS and cell cycle arrest at the G0/G1 phase and has anti-proliferative properties in several cancer cell lines and in in vivo cancer models.
AdipoGen Thapsigargin
Chemical. CAS 67526-95-8. Formula C34H50O12. Molecular Weight 650.75. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs IC50 values are cell type-dependent and range from ~2-80 nM. Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. Thapsigargin shows anti-inflammatory and anti-cancer effects.
AdipoGen TPEN
Chemical. CAS 16858-02-9. Formula C26H28N6. MW 424.5. TPEN is a cell permeable metal ion chelator. TPEN is a chelator that has a high affinity for zinc Zn2, next to other transition metals Zn2 >Fe2 >Mn2 and is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. TPEN has lower affinity for Ca2 and Mg2 and can also form complexes with other soft metal ions such as Cd2. In addition to a heavy metal chelator, TPEN is also known to be an apoptosis inducer. Depletion of zinc by TPEN induces apoptosis in several cell lines. TPEN shows anticancer activity through induction of caspase-dependent apoptosis, via reactive oxygen species ROS signaling mechanism and inhibiting cell autophagy. TPEN also inhibits RNA binding protein Lin28 and has been shown to be useful in extracting Abeta depostis from Alzheimers disease brain tissue.
Biomatik Corporation Puromycin, Dihydrochloride. Grade Biotechnology. Storage -20C. CAS 58-58-2
Puromycin, Dihydrochloride. Grade Biotechnology. Storage -20C. CAS 58-58-2
Biomatik Corporation DNase II, Porcine Pancreas, 12000 Kunitz U/MG. Grade Biotechnology. Storage -20C. CAS 9025-64-3
DNase II, Porcine Pancreas, 12000 Kunitz U/MG. Grade Biotechnology. Storage -20C. CAS 9025-64-3
Biomatik Corporation T4 DNA Ligase, 5U/uL One pouch containing 2 tubes T4 and 10X buffer. Grade Biotechnology. Storage -20C.
T4 DNA Ligase, 5U/uL One pouch containing 2 tubes T4 and 10X buffer. Grade Biotechnology. Storage -20C.
AdipoGen L-Alanyl-L-glutamine
Chemical. CAS 39537-23-0. Formula C8H15N3O4. MW 217.22. Synthetic. L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine Ala-Gln and Gylcyl-L-glutamine Gly-Gln are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant peroxide and anti-apoptosis LPS-induced factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy.
AdipoGen Elbasvir
Chemical. CAS 88321-09-9. Formula C17H30N2O5. MW 342.4. Aloxistatin is a cell permeable irreversible inhibitor of lysosomal and cytosolic cysteine proteases cathepsin B an L, calpain 1/2, papain and has diverse biological activities. It is an ethyl ester form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L.
AdipoGen PLX4720
Chemical. CAS 918505-84-7. Formula C17H14ClF2N3O3S. MW 413.8. Synthetic. Potent and selective cell permeable B-Raf V600E and c-Raf-1 Y340D/Y341D inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-RafV600E-bearing tumor cell lines.
AdipoGen Ixazomib MLN2238
Chemical. CAS 1072833-77-2. Formula C14H19BCl2N2O4. MW 361. Synthetic. Potent selective and reversible proteasome inhibitor all proteolytic subunits. Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome IC50=3.4nM. Cross-reacts and inhibits the trypsin-like beta2 subunit IC50=3.5µM and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing PGPH beta1 subunit IC50=0.03µM. Anticancer compound effective in cell-based assays, in xenografts and against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma. Biologically active form of the prodrug MLN9708 AG-CR1-3671. Exhibits improved pharmacodynamics and antitumor activity compared to bortezomib in various B-cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models.
AdipoGen C646
Chemical. CAS 328968-36-1. Formula C24H19N3O6. MW 445.4. Reversible cell permeable p300/CBP histone acetyltransferase HAT inhibitor. Specific inhibition to p300 86% compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases <10%. Cell growth inhibitor in melanoma and non-small-cell-lung NSCL human cancer cell lines.
AdipoGen PK 11195
Chemical. CAS 85532-75-8. Formula C21H21ClN2O. MW 352.9. Selective peripheral benzodiazepine antagonist. Apoptosis enhancer. Glucose-induced insulin secretion inhibitor. Induces mitochondria cytochrome c release. Anticancer compound. Antiproliferative. Pharmacological tool in autophagy.