Thioureas
Biomatik Corporation Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Glucose Oxidase, 100U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
AdipoGen Necrostatin-5 Nec-5
Chemical. CAS 337349-54-9. Formula C19H17N3O2S2. MW 383.5. Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective
Biomatik Corporation Glucose Oxidase, 225U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
Glucose Oxidase, 225U/MG. Grade High Purity. Storage -20C. CAS 9001-37-0
AdipoGen Boc-Leu-Arg-Arg-AMC
Chemical. CAS 109358-46-5 free base. Formula C33H52N10O7 . C2H4O2. MW 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues R and K. Excitation 380nm. Emission 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Q-VD-OPh
Chemical. CAS 1135695-98-5 anhydrous. Formula C26H25F2N3O6. MW 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl OPh group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
eMolecules 887913-52-2 | N-BOC-N'-METHYL THIOUREA | AstaTech | MFCD16036320 | 190.260 | C7H14N2O2S | 95.000 | CNC(=S)NC(=O)OC(C)(C)C | 0.25g | 296384358
N-BOC-N'-METHYL THIOUREA | AstaTech | 887913-52-2 | MFCD16036320 | 190.260 | C7H14N2O2S | 95.000 | CNC(=S)NC(=O)OC(C)(C)C | 0.25g | 296384358
AdipoGen LY2835219
Chemical. CAS 1231930-82-7. Formula C27H32F2N8 . CH4O3S. MW 602.7. LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 CDK4 and CDK6 IC50s = 2 and 10 nM, respectively. Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.
Matrix Scientific 1,3-DIBUTYL-2-THIOUREA-250G
1,3-Dibutyl-2-thiourea, 250g,C9H20N2S, MFCD00004926, mw 188.34, [109-46-6]
eMolecules 6938-68-7 | 2-METHYLAMINO THIOUREA | AstaTech | MFCD00010147 | 105.160 | C2H7N3S | 96.000 | CN(N)C(N)=S | 25g | 410713857
2-METHYLAMINO THIOUREA | AstaTech | 6938-68-7 | MFCD00010147 | 105.160 | C2H7N3S | 96.000 | CN(N)C(N)=S | 25g | 410713857
AdipoGen GSH-OEt
Chemical. CAS 92614-59-0. Formula C12H21N3O6S. MW 335.38. Synthetic. GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione GSH and glutathione ethyl ester GSH-OEt supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
![eMolecules 27231-36-3 | 2-Mercapto-5-methylbenzimidazole | Combi-Blocks | MFCD00010617 | 164.230 | C8H8N2S | 95.000 | Cc1ccc2[nH]c(S)nc2c1 | 1g | 290687361](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502184018.JPG-250.jpg)
eMolecules 27231-36-3 | 2-Mercapto-5-methylbenzimidazole | Combi-Blocks | MFCD00010617 | 164.230 | C8H8N2S | 95.000 | Cc1ccc2[nH]c(S)nc2c1 | 1g | 290687361
2-Mercapto-5-methylbenzimidazole | Combi-Blocks | 27231-36-3 | MFCD00010617 | 164.230 | C8H8N2S | 95.000 | Cc1ccc2[nH]c(S)nc2c1 | 1g | 290687361
AdipoGen 4-Methylumbelliferone
Chemical. CAS 90-33-5. Formula C10H8O3. MW 176.17. 4-Methylumbelliferone 4-MU is a selective inhibitor of hyaluronan HA by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan HA is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer. Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 plateau above pH10. The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data lambdaex=360nm lambdaem=448nm pH > 9.
AdipoGen R-Roscovitine
Chemical. CAS 186692-46-6. Formula C19H26N6O. MW 354.5. Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase IC50 = 450 nM, CDK2 IC50 = 700 nM and CDK5/p35 IC50 = 160 nM. Inhibits M phase promoting factor MPF kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways10. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Reviews.