Thioureas
AdipoGen Z-Leu-Leu-Leu-AMC
Chemical. CAS 152015-61-7. Formula C36H48N4O7. MW 648.8. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Excitation 345nm. Emission 445nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Pifithrin-alpha HBr
Chemical. CAS 63208-82-2. Formula C16H18N2OS . HBr. MW 286.4 . 80.9. p53 inhibitor. Reversibly blocks p53-dependent transcriptional activation. Tool to combat side effects of cancer therapy. Apoptosis inhibitor.
AdipoGen Q-VD-OPh
Chemical. CAS 1135695-98-5 anhydrous. Formula C26H25F2N3O6. MW 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl OPh group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
AdipoGen Boc-Leu-Arg-Arg-AMC
Chemical. CAS 109358-46-5 free base. Formula C33H52N10O7 . C2H4O2. MW 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues R and K. Excitation 380nm. Emission 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Z-Leu-Arg-Gly-Gly-AMC
Chemical. CAS 167698-68-2 free base. Formula C34H44N8O8 . C2HF3O2. MW 692.8 . 114.0. Fluorogenic tetrapeptide substrate for ubiquitin C-terminal hydrolases UCHs, e.g. UCHL3 and isopeptidase T. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and SENP7. Excitation 380nm. Emission 460nm.
Allylthiourea, 98%, Thermo Scientific™
CAS: 109-57-9 Molecular Formula: C4H8N2S Molecular Weight (g/mol): 116.182 InChI Key: HTKFORQRBXIQHD-UHFFFAOYSA-N Synonym: allylthiourea,n-allylthiourea,thiosinamine,1-allyl-2-thiourea,rhodalline,thiosinamin,tiosinamine,1-allylthiourea,aminosin,rhodallin PubChem CID: 1549517 ChEBI: CHEBI:74079 IUPAC Name: prop-2-enylthiourea SMILES: C=CCNC(=S)N
Thiourea, Cytiva
CAS: 45-001-296 Molecular Formula: CH4N2S
1-Adamantylthiourea 97.0+%, TCI America™
CAS: 25444-82-0 Molecular Formula: C11H18N2S Molecular Weight (g/mol): 210.339 MDL Number: MFCD01321124 InChI Key: LRWQENBAFMBIJR-UHFFFAOYSA-N PubChem CID: 796429 IUPAC Name: 1-adamantylthiourea SMILES: C1C2CC3CC1CC(C2)(C3)NC(=S)N