Thioureas
eMolecules 1,3-Diethyl-2-thiourea | 105-55-5 | MFCD00004925 | 25g
Oakwood Chemicals | 1,3-Diethyl-2-thiourea | 25g | 480149343 | 098974 | | 105-55-5 | MFCD00004925 | 132.230 | C5H12N2S
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eMolecules 6-Phenyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one | 36822-11-4 | MFCD00465574 | 1g
Combi-Blocks, Inc. | 6-Phenyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one | 1g | 569293854 | QZ-6033 | 95.000 | 36822-11-4 | MFCD00465574 | 204.250 | C10H8N2OS
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AdipoGen Indole-3-carbinol
Chemical. CAS 700-06-1. Formula C9H9NO. MW 147.2. Natural breakdown product of glucosinolates found in cruciferous vegetables. Widely used multifunctional aryl hydrocarbon receptor AhR agonist. AhR is emerging as a transcription factor involved in the regulation of both innate and adaptive immune responses in various immune cell types, including lymphocytes and antigen-presenting cells APCs. Studies have associated overexpression of AHR with the activation of cancer processes such as proliferation, epithelial-to-mesenchymal transition EMT, DNA damage, inflammation, migration and angiogenesis. Used to increase the population of innate lymphoid cells 3 ILC3 in gut microbiota. Chemopreventive agent that has multiple anticarcinogenic and antitumor properties and suppresses the proliferation of selective cancer cells, including breast cancer, prostate cancer, endometrial cancer, colon cancer and leukemic cells. Protects against nephrotoxicity. Proapoptotic.
AdipoGen Necrostatin-5 Nec-5
Chemical. CAS 337349-54-9. Formula C19H17N3O2S2. MW 383.5. Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective
AdipoGen Raptinal
Chemical. CAS 1176-09-6. Formula C28H18O2. MW 386.4. Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4µM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore MPTP formation, suggesting a mitochondrial outer membrane permeabilization MOMP model of cytochrome c release.
eMolecules Thiourea-13C | 113899-66-4 | MFCD00084092 | 500mg
Toronto Research Chemicals | Thiourea-13C | 500mg | 601600936 | T375454 | | 113899-66-4 | MFCD00084092 | 77.110 | CH4N2S
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eMolecules Oakwood Chemicals Thiourea ACS Reagent Grade 25g 480154135 103320 62-56-6 MFCD00008067 76.120 CH4N2S
Oakwood Chemicals Thiourea ACS Reagent Grade 25g 480154135 103320 62-56-6 MFCD00008067 76.120 CH4N2S
AdipoGen Z-Leu-Leu-Leu-BOH2 MG-262
Chemical. CAS 179324-22-2. Formula C25H42BN3O6. MW 491.4. Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Similar structure as MG-132 AG-CP3-0011 but much higher potency.
AdipoGen Z-Leu-Leu-Glu-AMC
Chemical. CAS 348086-66-8. Formula C35H44N4O9. MW 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing PGPH caspase-like activity of the 20S proteasome. Excitation 380nm. Emission 460nm.
AdipoGen Z-Leu-Leu-Nva-CHO MG-115
Chemical. CAS 133407-86-0. Formula C25H39N3O5. MW 461.6. Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.
AdipoGen Q-VD-OPh
Chemical. CAS 1135695-98-5 anhydrous. Formula C26H25F2N3O6. MW 513.5. Synthetic. Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl OPh group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies.
AdipoGen Suc-Leu-Leu-Val-Tyr-AMC
Chemical. CAS 94367-21-2. Formula C40H53N5O10. MW 763.9. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases. Extinction 380nm. Emission 460 nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Suc-Leu-Leu-Val-Tyr-AMC
Chemical. CAS 94367-21-2. Formula C40H53N5O10. MW 763.9. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases. Extinction 380nm. Emission 460 nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Boc-Leu-Arg-Arg-AMC
Chemical. CAS 109358-46-5 free base. Formula C33H52N10O7 . C2H4O2. MW 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues R and K. Excitation 380nm. Emission 460nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Alsterpaullone
Chemical. CAS 237430-03-4. Formula C16H11N3O3. MW 293.3. Potent CDK1/cyclin B IC50 = 35 nM inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E IC50 = 200 nM, CDK5/p25 IC50 = 40 nM, CDK5/p35 IC50 = 40 nM. GSK-3beta glycogen synthase kinase-3beta inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.