Thioureas
AdipoGen Desacetylcolchicine tartrate
Chemical. CAS 49720-72-1. Formula C20H23NO5 . C4H6O6. MW 357.4 . 150.1. Synthetic. Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.
AdipoGen GSH-OEt
Chemical. CAS 92614-59-0. Formula C12H21N3O6S. MW 335.38. Synthetic. GSH-OEt is cellpermeable and has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. GSH-OEt is a protective agent against cellular damage, such as cataracts and mitochondrial degeneration. It undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Glutathione monoethyl ester may be used to supplement cellular pools of GSH in vitro and in vivo and can prevent ROS formation, neutralize toxic products and block apoptosis pathway. The effect of glutathione GSH and glutathione ethyl ester GSH-OEt supplementation on GSH homeostasis and exercise-induced oxidative stress was also examined. Glutathione ethyl ester protects against cisplatin-induced ototoxicity in the rat.
AdipoGen Desacetylcolchicine tartrate
Chemical. CAS 49720-72-1. Formula C20H23NO5 . C4H6O6. MW 357.4 . 150.1. Synthetic. Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.
AdipoGen PLX4720
Chemical. CAS 918505-84-7. Formula C17H14ClF2N3O3S. MW 413.8. Synthetic. Potent and selective cell permeable B-Raf V600E and c-Raf-1 Y340D/Y341D inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-RafV600E-bearing tumor cell lines.
AdipoGen Necrostatin-5 Nec-5
Chemical. CAS 337349-54-9. Formula C19H17N3O2S2. MW 383.5. Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Cardioprotective
AdipoGen Suc-Leu-Leu-Val-Tyr-AMC
Chemical. CAS 94367-21-2. Formula C40H53N5O10. MW 763.9. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases. Extinction 380nm. Emission 460 nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Z-Leu-Leu-Glu-AMC
Chemical. CAS 348086-66-8. Formula C35H44N4O9. MW 664.8. Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing PGPH caspase-like activity of the 20S proteasome. Excitation 380nm. Emission 460nm.
AdipoGen Carboplatin
Chemical. CAS 41575-94-4. Formula C6H12N2O4Pt. MW 371.3. Potent platinum-based antineoplastic agent. Analog of cisplatin Prod. No. AG-CR1-3590 with reduced nephrotoxicity and higher stability. Antitumor agent. Forms inter- and intrastrand DNA adducts/crosslinks, consequently blocking DNA replication and transcription and inducing cell death. Interferes with cell division by mitosis. The damaged DNA elicits DNA repair mechanisms, which in turn activate apoptosis when repair is impossible. Apoptosis inducer. Enhances radiation-induced single-strand DNA breakage.
AdipoGen MnTBAP chloride
Chemical. CAS 55266-18-7. Formula C48H28MnN4O8Cl. MW 879.2. Cell permeable superoxide dismutase SOD mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions peroxynitrite scavenger, but not a scavenger of nitric oxide NO. Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK. .
AdipoGen MS-275
Chemical. CAS 209783-80-2. Formula C21H20N4O3. MW 376.4. HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Review. Promotes either self-renewal or differentiation of embryonic stem cells.
AdipoGen Z-Leu-Leu-Phe-CHO
Chemical. CAS 133429-58-0. Formula C29H39N3O5. MW 509.7. Reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC.
AdipoGen 1 5-Isoquinolinediol
Chemical. CAS 5154-02-9. Formula C9H7NO2. MW 161.2. PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS inducible nitric oxide synthase/NOS II inhibitor. Stimulates homologous recombination.
AdipoGen Z-Leu-Leu-Leu-BOH2 MG-262
Chemical. CAS 179324-22-2. Formula C25H42BN3O6. MW 491.4. Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Similar structure as MG-132 AG-CP3-0011 but much higher potency.
AdipoGen Colcemid
Chemical. CAS 477-30-5. Formula C21H25NO5. MW 371.4. Semisynthetic from colchicine Prod. No. AG-CN2-0048. Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation inactivates spindle fibre formation. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.
AdipoGen Boc-Leu-Arg-Arg-AMC
Chemical. CAS 109358-46-5 free base. Formula C33H52N10O7 . C2H4O2. MW 700.8 . 60.1. Fluorogenic tri-peptide substrate for measuring the trypsin-like peptidase activity of the 20S proteasome. Substrate for the Kex2 endopeptidase from S. Cervisiae, which has substrate specificity toward the C-terminal side of LR, PR and RR sequences. Can be cleaved by Kallikrein 5 with a P1 site preference for basic residues R and K. Excitation 380nm. Emission 460nm. This substrate is useful for inhibitor screening and kinetic analysis.