Thioureas
Biomatik Corporation T4 DNA Ligase, 5U/uL One pouch containing 2 tubes T4 and 10X buffer. Grade Biotechnology. Storage -20C.
T4 DNA Ligase, 5U/uL One pouch containing 2 tubes T4 and 10X buffer. Grade Biotechnology. Storage -20C.
AdipoGen Thapsigargin
Chemical. CAS 67526-95-8. Formula C34H50O12. Molecular Weight 650.75. Thapsigargin is a non-competitive, cell permeable inhibitor of calcium transport by SERCAs IC50 values are cell type-dependent and range from ~2-80 nM. Inhibition of SERCAs leads to an increase in intracellular calcium, which has been linked to cell activation, release of histamine from mast cells, and increased proliferation of certain types of cancer cells. Thapsigargin shows anti-inflammatory and anti-cancer effects.
AdipoGen PTACH
Chemical. CAS 848354-66-5. Formula C20H26N2O2S2. MW 390.56. Synthetic. Non-hydroxamate HDAC inhibitor HDACi IC50 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively. Cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro EC50 = 1.1 - 9.1mM. Also reactivates latent HIV-1 gene expression.
AdipoGen TPEN
Chemical. CAS 16858-02-9. Formula C26H28N6. MW 424.5. TPEN is a cell permeable metal ion chelator. TPEN is a chelator that has a high affinity for zinc Zn2, next to other transition metals Zn2 >Fe2 >Mn2 and is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. TPEN has lower affinity for Ca2 and Mg2 and can also form complexes with other soft metal ions such as Cd2. In addition to a heavy metal chelator, TPEN is also known to be an apoptosis inducer. Depletion of zinc by TPEN induces apoptosis in several cell lines. TPEN shows anticancer activity through induction of caspase-dependent apoptosis, via reactive oxygen species ROS signaling mechanism and inhibiting cell autophagy. TPEN also inhibits RNA binding protein Lin28 and has been shown to be useful in extracting Abeta depostis from Alzheimers disease brain tissue.
AdipoGen TPEN
Chemical. CAS 16858-02-9. Formula C26H28N6. MW 424.5. TPEN is a cell permeable metal ion chelator. TPEN is a chelator that has a high affinity for zinc Zn2, next to other transition metals Zn2 >Fe2 >Mn2 and is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. TPEN has lower affinity for Ca2 and Mg2 and can also form complexes with other soft metal ions such as Cd2. In addition to a heavy metal chelator, TPEN is also known to be an apoptosis inducer. Depletion of zinc by TPEN induces apoptosis in several cell lines. TPEN shows anticancer activity through induction of caspase-dependent apoptosis, via reactive oxygen species ROS signaling mechanism and inhibiting cell autophagy. TPEN also inhibits RNA binding protein Lin28 and has been shown to be useful in extracting Abeta depostis from Alzheimers disease brain tissue.
AdipoGen Colcemid
Chemical. CAS 477-30-5. Formula C21H25NO5. MW 371.43. Synthetic. Depolymerizes microtubules and blocks mitosis at metaphase. Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.
AdipoGen Aluminon
Chemical. CAS 569-58-4. Formula C22H14O9 . 3NH3. MW 422.3 . 51.1. Synthetic. Aluminon, the triammonium salt of aurintricarboxylic acid, is a dye commonly used to detect the presence of the aluminium ion in an aqueous solution. In addition to its use in qualitative inorganic analysis, aluminon has applications in pigment production. It forms brilliantly colored lake pigments with aluminum, chromium, iron and beryllium. Spectral data AL-Complex Absorbance at ~525nm. Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of RNA-directed DNA polymerase and topoisomerase II. Angiogenesis inhibitor. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells.
AdipoGen Budesonide
Chemical. CAS 51333-22-3. Formula C25H34O6. MW 430.5. Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors EC50=45.7pM in a transactivation assay, selective for glucocorticoid over mineralocorticoid receptors. Budesonide is a synthetic anti-inflammatory agent that displays chemopreventive activity. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis and inflammatory bowel disease and is evaluated in prevention of lung cancer. It prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. It also reverses DNA hypomethylation and modulates expression of cancer related genes. Due to its potent activity, as an inhaled glucocorticoid, in reducing airway inflammation, Budesonide has potential as treatment for early COVID-19 infection.
AdipoGen Salidroside
Chemical. CAS 10338-51-9. Formula C14H20O7. MW 300.3. Synthetic. Glycoside isolated from plants, most commonly from members of the genus Rhodiola, with many biological activities. Shown to have neuroprotective, antioxidant, antiviral, antidepressant, cardioprotective, anti-inflammatory and anticancer activity. Ameliorates insulin resistance.
AdipoGen Ozagrel
Chemical. CAS 82571-53-7. Formula C13H12N2O2. MW 228.2. Synthetic. Ozagrel, an antithrombic drug, is a potent and selective TXA Synthase thromboxane A2 TXAS inhibitor. Acts as a selective inhibitor of TXAS with an IC50=11nM. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke, and antihypertensive effects in spontaneously hypertensive rats.
AdipoGen Budesonide
Chemical. CAS 51333-22-3. Formula C25H34O6. MW 430.5. Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors EC50=45.7pM in a transactivation assay, selective for glucocorticoid over mineralocorticoid receptors. Budesonide is a synthetic anti-inflammatory agent that displays chemopreventive activity. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis and inflammatory bowel disease and is evaluated in prevention of lung cancer. It prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. It also reverses DNA hypomethylation and modulates expression of cancer related genes. Due to its potent activity, as an inhaled glucocorticoid, in reducing airway inflammation, Budesonide has potential as treatment for early COVID-19 infection.
eMolecules 62-56-6 | Thiourea | Chem-Impex | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5kg | 342448903
Thiourea | Chem-Impex | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5kg | 342448903
![eMolecules 18741-24-7 | 2-Mercapto-3-phenylquinazolin-4-one | Oakwood Chemical | MFCD00023895 | 254.310 | C14H10N2OS | 95.000 | O=c1n(-c2ccccc2)c(=S)[nH]c2ccccc12 | 100mg | 537713488](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502149935.JPG-250.jpg)
eMolecules 18741-24-7 | 2-Mercapto-3-phenylquinazolin-4-one | Oakwood Chemical | MFCD00023895 | 254.310 | C14H10N2OS | 95.000 | O=c1n(-c2ccccc2)c(=S)[nH]c2ccccc12 | 100mg | 537713488
2-Mercapto-3-phenylquinazolin-4-one | Oakwood Chemical | 18741-24-7 | MFCD00023895 | 254.310 | C14H10N2OS | 95.000 | O=c1n(-c2ccccc2)c(=S)[nH]c2ccccc12 | 100mg | 537713488
eMolecules 62-56-6 | Thiourea | Combi-Blocks | MFCD00008067 | 76.120 | CH4N2S | 98.000 | NC(N)=S | 100g | 290691754
Thiourea | Combi-Blocks | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 98.000 | NC(N)=S | 100g | 290691754
![Sigma Aldrich Fine Chemicals Biosciences [beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1, O-Me-Tyr2, Orn8]-Oxytocin >=93% (HPLC), solid | 77327-45-8 | MFCD00135712 | 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501769998.PNG-250.jpg)
Sigma Aldrich Fine Chemicals Biosciences [beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1, O-Me-Tyr2, Orn8]-Oxytocin >=93% (HPLC), solid | 77327-45-8 | MFCD00135712 | 1MG
[beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1, O-Me-Tyr2, Orn8]-Oxytocin >=93% (HPLC), solid | Purity: >=93% (HPLC) | Mol Wt: 1075.3 | 77327-45-8 | MFCD00135712 | 1MG
