Anthracyclines
Apexbio Technology LLC Daunorubicin 20830-81-3 50mg
Daunorubicin (20830-81-3) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit this target thereby disrupting nucleic acid synthesis within tumor cells Daunorubicin exerts its biological activity primarily through stabilizing the topoisomerase II-DNA cleavage complex interfering with DNA replication and transcription In in vitro studies daunorubicin demonstrates inhibition of metabolic incorporation of nucleoside precursors into DNA and RNA with reported IC50 values for inhibition of leukemia cell growth ranging from 0 02 1 M depending on cellular context and assay conditions Based on these pharmacological properties daunorubicin holds research potential in oncology studies related to chemotherapy-induced genotoxicity and nucleic acid metabolism
Apexbio Technology LLC Daunorubicin 20830-81-3 10mg
Daunorubicin (20830-81-3) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit this target thereby disrupting nucleic acid synthesis within tumor cells Daunorubicin exerts its biological activity primarily through stabilizing the topoisomerase II-DNA cleavage complex interfering with DNA replication and transcription In in vitro studies daunorubicin demonstrates inhibition of metabolic incorporation of nucleoside precursors into DNA and RNA with reported IC50 values for inhibition of leukemia cell growth ranging from 0 02 1 M depending on cellular context and assay conditions Based on these pharmacological properties daunorubicin holds research potential in oncology studies related to chemotherapy-induced genotoxicity and nucleic acid metabolism
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mM (in 1mL DMSO)
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 50mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)