Cinnamic acids and derivatives
Selleck Chemical LLC BLU 451-E1877-1G
BLU 451 is a central nervous system (CNS)-penetrant wild-type EGFR-sparing covalent inhibitor of epidermal growth factor receptor (EGFR) exon 20 insertion (Ex20ins) with an IC50 of 7-78 nM It also exhibits a potent anti-tumor efficacy
Medchemexpress LLC Cinnamic acid | 621-82-9 | MFCD00004369 | 148.16 | 1 G
Cinnamic acid has potential use in cancer intervention, exhibiting IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate, and lung carcinoma cells. In addition to inhibiting tumor-cell proliferation, Cinnamic acid induces morphological changes consistent with melanocyte differentiation. Treatment with Cinnamic acid also leads to a dose-dependent loss of invasive capacity in various tumor lines.
- Endogenous metabolite
- Potential use in cancer intervention
- Exhibits dose-dependent growth inhibition in various tumor cells
- Induces morphological changes consistent with melanocyte differentiation
- Causes dose-dependent loss of invasive capacity in tumor lines
- Purity: 99.98%
- Appearance: Solid
- Color: White to off-white
- Initial source: Microorganisms
- Storage: powder at -20°C for 3 years, 4°C for 2 years; in solvent at -80°C for 2 years, -20°C for 1 year
Medchemexpress LLC 2-Hydroxycinnamic acid | 614-60-8 | MFCD00004379 | 98.71% | 164.16 | 100 MG
2-Hydroxycinnamic acid (Standard) serves as the analytical standard for 2-Hydroxycinnamic acid, intended for research and analytical applications. It is a phenolic acid possessing antimicrobial and antioxidant properties. This analytical standard grade compound is commonly employed in qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- Demonstrates antimicrobial activity against *Staphylococcus aureus* without susceptibility to drug resistance.
- Exhibits inhibitory effects on HIV/SARS-CoV S pseudovirus infection, with an IC50 of 0.3 mM.
- Possesses neuroprotective activity.
- Possesses antitumor activity.
Medchemexpress LLC (E)-Ethyl p-methoxycinnamate | 24393-56-4 | 99.4% | 206.24 | 1 ML
(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic, and anti-microbial effects. It acts as an inhibitor of COX-1 and COX-2 enzymes in vitro, with IC50 values of 1.12 μM and 0.83 μM, respectively. The product is intended for research use only and is not sold to patients.
- Natural product sourced from Kaempferia galangal.
- Exhibits anti-inflammatory, anti-neoplastic, and anti-microbial effects.
- Inhibits COX-1 (IC50: 1.12 μM) and COX-2 (IC50: 0.83 μM) in vitro.
- Shows moderate inhibitory activity against α-glucosidase (IC50: 50 μM).
- Inhibits migration and tubular structure formation in HUVECs.
- Exhibits cytotoxicity in various cancer cells.
- Induces apoptosis through caspase-3/7/8/9 activation in cancer cells.
- Inhibits bFGF and heparin-induced angiogenesis.
Medchemexpress LLC 3-carboxy-6-hydroxycoumarin | 56437-16-2 | MFCD16295011 | 99.9% | 206.15 g/mol | C10H6O5 | 1 ML
3-Carboxy-6-hydroxycoumarin is a coumarin-derived intermediate used in organic synthesis and chemical research. It is supplied in both solid form and as a 10 mM solution in DMSO for use in screening, synthesis, and analytical workflows.
- High purity, typically around 99.9%.
- Molecular formula C10H6O5 and molecular weight 206.15 g/mol.
- Available as a white to yellow solid and as a 10 mM solution in DMSO.
- Solid pack sizes commonly include 25 mg, 50 mg, 100 mg, 200 mg, and 500 mg.
- Storage recommendations: powder at -20°C (up to 3 years) or 4°C (up to 2 years).
- In solvent, store at -80°C (up to 6 months) or -20°C (up to 1 month).
Medchemexpress LLC M-carboxycinnamic acid bishydroxamide | 174664-65-4 | MFCD03453553 | 98.0% | 222.20 g·mol⁻¹ | C10H10N2O4 | 10 MG
m-Carboxycinnamic acid bishydroxamide (CBHA) is a small-molecule histone deacetylase (HDAC) inhibitor supplied for research use. It inhibits HDAC1 and HDAC3 with reported ID50 values of approximately 10 nM and 70 nM, respectively, and has been reported to induce apoptosis and suppress tumor growth in experimental models.
- Potent HDAC inhibitor with reported ID50 ≈ 10 nM (HDAC1) and ≈ 70 nM (HDAC3).
- High purity (98.0%).
- Molecular formula C10H10N2O4 and molecular weight 222.20 g·mol⁻¹.
- Suitable for biochemical and cell-based assays.
- Demonstrated induction of apoptosis and tumor-growth suppression in studies.
- Supplied as a research-grade chemical for laboratory use.
Apexbio Technology LLC BIBF 1202 894783-71-2 5mg
BIBF 1202 (CAS 894783-71-2) is a carboxylate metabolite derivative of BIBF 1120 characterized as a selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) kinase In biochemical assays BIBF 1202 demonstrates inhibitory activity against VEGFR2 kinase with an IC50 of 62 nM This compound is frequently employed in studies investigating the regulation of the VEGFR2 signaling pathway and its role in endothelial cell function Additionally BIBF 1202 is utilized in preclinical models related to tumor angiogenesis and associated pharmacological research
eMolecules 3-Hydroxycinnamic acid methyl ester | Combi-Blocks | 66417-46-7 | MFCD09259949 | 178.187 | C10H10O3 | 98.000 | COC(=O)\C=C\c1cccc(O)c1 | 1g | 232339016
3-Hydroxycinnamic acid methyl ester | Combi-Blocks | 66417-46-7 | MFCD09259949 | 178.187 | C10H10O3 | 98.000 | COC(=O)\C=C\c1cccc(O)c1 | 1g | 232339016
eMolecules 2'-(3-Fluorobenzyloxy)acetophenone | 845823-26-9 | MFCD06411645 | 1g
Oakwood Chemical | 2'-(3-Fluorobenzyloxy)acetophenone | 1g | 537680623 | 023221 | | 845823-26-9 | MFCD06411645 | 244.265 | C15H13FO2
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Medchemexpress LLC Trans-cinnamic acid-d7 | 343338-31-8 | 100.0% | 155.20 | C9HD7O2 | 10 MG
trans-Cinnamic acid-d7 is the deuterium-labeled analogue of trans-cinnamic acid, used as an internal standard and tracer in analytical chemistry and metabolic studies. It is supplied as a high-purity white to off-white solid intended for research applications.
- Deuterium-labeled for use as an internal standard in mass spectrometry and tracer studies.
- High reported purity (99.98%).
- White to off-white solid, stable under standard storage conditions.
- Suitable for analytical and metabolic research applications.
- Available in a 10 mg analytical-scale quantity.
eMolecules Ambeed / 2-Methoxycinnamic Acid / 5g / 490558558 / A377987 / / 6099-03-2 / MFCD00064238 / 178.187 / C10H10O3
Ambeed / 2-Methoxycinnamic Acid / 5g / 490558558 / A377987 / / 6099-03-2 / MFCD00064238 / 178.187 / C10H10O3
Medchemexpress LLC Ferulic acid methyl ester | 2309-07-1 | MFCD00017208 | 99.9% | 208.21 g/mol | C11H12O4 | 25 G
Ferulic acid methyl ester is the methyl ester derivative of ferulic acid used in biochemical and pharmacological research. It functions as a lipophilic antioxidant with reported activity in pathways such as p38 MAPK and autophagy, and is commonly used in in vitro and cell-based studies.
- High purity suitable for research applications.
- Lipophilic antioxidant and cell-permeable compound.
- Solid, off-white to pink appearance for easy handling.
- Available in multiple pack sizes, including 25 g.
- Stable when stored according to supplier recommendations (powder: -20°C or 4°C).
Selleck Chemical LLC BLU 451-E1877-100MG
BLU 451 is a central nervous system (CNS)-penetrant wild-type EGFR-sparing covalent inhibitor of epidermal growth factor receptor (EGFR) exon 20 insertion (Ex20ins) with an IC50 of 7-78 nM It also exhibits a potent anti-tumor efficacy
![eMolecules trans-[4-(trifluoromethoxy)cyclohexyl]methanamine;hydrochloride | | | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502160103.JPG-250.jpg)
eMolecules trans-[4-(trifluoromethoxy)cyclohexyl]methanamine;hydrochloride | | | 1g
Pharmablock | trans-[4-(trifluoromethoxy)cyclohexyl]methanamine;hydrochloride | 1g | 599151995 | PBJL100373-1 | | | | 233.660 | C8H15ClF3NO
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Selleck Chemical LLC p-Coumaric Acid S4759-25mg
p-Coumaric acid (4-Hydroxycinnamic acid P-Hydroxycinnamic acid 4-Coumaric acid Trans-p-Coumaric acid para-Coumaric Acid) is a hydroxy derivative of cinnamic acid found in a variety of edible plants and is reported to have antioxidant anti-inflammatory and antimicrobial activity