Cinnamic acids and derivatives
![Medchemexpress LLC 2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)- | 456-12-2 | MFCD00048045 | 99.8% | 297.35 g/mol | C18H19NO3 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000209428.png-250.jpg)
Medchemexpress LLC 2-Propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)- | 456-12-2 | MFCD00048045 | 99.8% | 297.35 g/mol | C18H19NO3 | 1 G
Aegeline is an alkaloid reference standard intended for research use that mimics the yeast SNARE protein Sec22p and suppresses α-synuclein and Bax toxicity in yeast while exhibiting antioxidant activity.
- Alkaloid reference standard for research use.
- Cas number: 456-12-2.
- Chemical formula: C18H19NO3; molecular weight: 297.35 g/mol.
- Purity 99.81% (as provided on the certificate of analysis).
- Form: white to off-white solid powder.
- Solubility: soluble in DMSO (100 mg/mL); in vivo formulations listed for dosing preparations.
- Storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); in solution at -80°C or -20°C for shorter periods.
- Pack size: 1 g.
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 25 MG
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. Curcumin 5-8 also improves insulin resistance and insulin sensitivity. This product is for research use only and not sold to patients.
- Potent and orally active naturally active curcumin (CUR) analog.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance and insulin sensitivity.
- For research use only and not sold to patients.
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 100 MG
Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It causes a dose-dependent decrease of IL-12 p40 and blocks CD40L-induced translocation of NF-κB to the nucleus, reducing activation of the IL-12 p40 gene. This compound is a weaker inhibitor of TK, often used to differentiate TK-mediated effects from other non-specific effects.
- Inhibits CD40L-stimulated IL-12 production
- Reduces antigen-induced generation of Th1 cells
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Useful for differentiating TK-mediated effects from non-specific effects
- For research use only
Apexbio Technology LLC Cinnamic acid 621-82-9 200mg
Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection
Apexbio Technology LLC Entacapone 130929-57-6 100mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Apexbio Technology LLC Cinnamic acid 621-82-9 100mg
Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection
Bruker Daltonics alpha-Cyano-4-hydroxycinnamic acid | 28166-41-8 | MFCD00004204
alpha-Cyano-4-hydroxycinnamic acid | Mol Wt: 189.17 | 28166-41-8 | MFCD00004204
Cayman Chemical Ferulic Acid ethyl ester, Purity: ≥98%, CAS: 4046-02-0, 1 g
A lipophilic derivative of ferulic acid, with increased ability to cross cell membranes; less DPPH radical scavenging capacity than ferulic acid (IC50 = 66.7 μM for FAEE vs. 44.6 μM for ferulic acid); increases the expression of HO-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide
Selleck Chemical LLC Curcumin S1848-1g
Curcumin (Diferuloylmethane Natural Yellow 3 Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric which is a member of the ginger family (Zingiberaceae) It is an inhibitor of p300 histone acetylatransferase IC50 25 M and Histone deacetylase (HDAC) activates Nrf2 pathway and supresses the activation of NF- B Curcumin induces mitophagy autophagy apoptosis and cell cycle arrest with antitumor activity Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus hepatitis C virus HIV and so on
Sigma Aldrich Fine Chemicals Biosciences alpha-Cyano-4-hydroxycinnamic acid | 28166-41-8 | MFCD00004204 | 10 g
alpha-Cyano-4-hydroxycinnamic acid | Purity: ≥98% | Mol Wt: 189.17 | 28166-41-8 | MFCD00004204 | 10 g
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | MFCD00008365 | 10g
Curcumin from Curcuma longa (Turmeric), powder | Purity: 65% | 368.38 | 458-37-7 | MFCD00008365 | 10g
Medchemexpress LLC MRL-494 (hydrochloride) | 2699937-04-5 | 98.6% | 10 MG
MRL-494 hydrochloride is an antibacterial agent and an inhibitor of β-barrel assembly machine A (BamA). It is impervious to efflux and the outer membrane permeability barrier, making it effective against both Gram-positive and Gram-negative bacteria. This agent lethally disrupts the cytoplasmic membrane and inhibits outer membrane protein biogenesis by targeting BamA.
- Inhibits β-barrel assembly machine A (BamA)
- Effective against Gram-positive bacteria
- Effective against Gram-negative bacteria
- Disrupts cytoplasmic membrane
- Inhibits outer membrane protein biogenesis
- White to off-white solid
Accela Chembio Inc 4-(dimethylamino)cinnamic Acid | 5g | 1552-96-1 | MFCD00004397 | 97+% | Shelf Life: 1260 Days | Light Sensitive
4-(dimethylamino)cinnamic Acid | 5g | 1552-96-1 | MFCD00004397 | 97+% | Shelf Life: 1260 Days | Light Sensitive
Cayman Chemical m-Coumaric Acid, Purity: ≥98%, CAS: 588-30-7, 1 g
An active metabolite of polyphenols; inhibits cumene hydroperoxide-induced oxidation of DNA (IC50 = 54.7 µM); induces neurite outgrowth of fetal rat hippocampal neurons at 10 µM; induces apoptosis and cell cycle arrest at the G0/G1 phase in HeLa cells at 5 and 10 mM, respectively; increases locomotor activity in mice at 3 mmol/kg