Coumarins and derivatives
Sigma Aldrich 6,7-Dihydroxycoumarin
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Medchemexpress LLC Coumarin boronic aci 5mg
Coumarin boronic acid is a fluorescent probe The excitation and emission wavelengths of coumarin boronic acid are set to 360 nm and 430 nm respectively Coumarin boronic acid can be used to monitor the formation of amino acid and protein hydroxyl peroxides in real time which is beneficial for understanding the mechanisms of oxidative stress and protein post-translational modification[1]
Apexbio Technology LLC HX 531 188844-34-0 25mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Medchemexpress LLC 2H-1-Benzopyran-2-one, 6-bromo- | 19063-55-9 | 225.04 | 10 G
6-Bromocoumarin (6-Bromochromen-2-one) is a chemical compound identified as a potential anti-bacterial agent. It has been noted for not inhibiting 17β-HSD1 and for showing affinity for α and β estrogen receptors.
- Potential anti-bacterial agent
- Does not inhibit 17β-HSD1
- Shows affinity for α and β estrogen receptors
TARGETMOL CHEMICALS INC 7-ACETOXY-4-METHYLCOUMAR 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 7-Acetoxy-4-methylcoumarin is a fluorogenic substrate for carboxylesterase yielding a blue fluorescent solution upon cleavage. The compound has been used in aprotic media a cell membrane environmental mimic to study superoxide and related oxyl-radical reactions of model biological membranes dispersed in aqueous media. Due to the ability for AchE to cleave and activate 7-Acetoxy-4-methylcoumarin the fluorogenic substrate has been used to study the AchE inhibitor Tacrine·HCl (sc-200172). The compound has also been isolated from Trigonella foenum graceum. purity: 88%
Cayman Chemical 7-Acetoxy-4-methylcoumarIn 5g
A fluorogenic substrate for carboxylesterase and AChE; upon hydrolysis by carboxylic esterase or AChE, 4-MU is released, which displays pH-dependent excitation maxima of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, and an emission maximum between 445-454 nm; has been used to detect the presence of carboxylesterases in isolated human lung tissue
Accela Chembio Inc MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
MF: C14H15NO4 | MW: 261.27 | ?97% | BP: 438.2? at 760 mmHg.
Medchemexpress LLC Coumarin 106 | 41175-45-5 | MFCD00041949 | >98.0% | 281.35 | C18H19NO2 | 50 MG
Coumarin 106 is a dipolar laser dye used in research that also functions as a cholinesterase inhibitor. It exhibits mixed-type inhibition of acetylcholinesterase (reported pIC50 4.97, Ki 2.36 μM) and lower potency against butyrylcholinesterase (pIC50 4.56). Molecular formula C18H19NO2 and molecular weight 281.35. In vitro data report no toxicity in Caco-2 cells.
- Dipolar laser dye useful for fluorescence and photonic applications.
- Inhibits acetylcholinesterase with reported pIC50 4.97 and Ki 2.36 μM.
- Also inhibits butyrylcholinesterase with pIC50 4.56.
- Molecular weight 281.35 and formula C18H19NO2.
- Reported non-toxic in Caco-2 cell assays.
- Supplied as a 50 mg research reagent.
Selleck Chemical LLC 7-Methylcoumarin-E0656-100MG
7-Methylcoumarin can inhibit the growth of S aureus and the growth of Gram-positive bacteria within a concentration of 0 8 3 6 g/ml and also has a strong hepatoprotective activity
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 100mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Medchemexpress LLC 2-oxo-2H-1-benzopyran-3-carboxylic acid | 531-81-7 | MFCD00006852 | 99.9% | 190.15 g/mol | C10H6O4 | 50 G
Coumarin-3-carboxylic acid is a small-molecule research reagent (2-oxochromene-3-carboxylic acid) used as a fluorescent probe for hydroxyl radicals and as a synthetic building block. Supplied as a high-purity solid, it is suitable for in vitro studies and can be formulated for in vivo dosing when required.
Indofine Chemical 7-Diethylaminocou, 98%, 250 Mg
7-DIETHYLAMINOCOUMARIN 250 MG, Coumarin, C13H15NO2, MW: 217.27, 98%, 20571-42-0, MFCD00232946
Cayman Chemical 4-HydroxycoumarIn 100g
A coumarin; inhibits vitamin K1 epoxidation and prothrombin synthesis by 18 and 67%, respectively, in cell-free assays at 6.2 mM; has been used in the synthesis of anticoagulants, as well as antithrombotic, anti-inflammatory, antibacterial, and antifungal agents
Indofine Chemical 5,6,7,3',4'-Pentame, 98%, 5 Mg
5,6,7,3',4'-PENTAMETHOXYFLAVONE, Flavonoid & Coumarins, 2306-27-6, 98%, 5 mg
Cayman Chemical 3-HydroxycoumarIn 1g
A coumarin with diverse biological activities; inhibits 15-LO-1 (IC50 = 9.5 µM); scavenges DPPH radicals in a cell-free assay (IC50 = 0.61 mM); inhibits lipid peroxidation in vitro (IC50 = 69.07 mM); protective against UVB-induced embryotoxicity in sea urchins