Coumarins and derivatives
Medchemexpress LLC Coumarin | 91-64-5 | MFCD00006850 | 146.15 | 1 G
Coumarin is a potent and orally active anti-inflammatory agent. It also shows an antinociceptive effect, and antibacterial, antifungal, and anticancer activity.
- Potent and orally active anti-inflammatory agent
- Shows antinociceptive effect
- Exhibits antibacterial, antifungal, and anticancer activity
Cayman Chemical 3azido7hydroxy Coumarin
A click-reactive fluorescent dye; Upon CuAAC in a biological system, a fluorescent product is produced that displays excitation/emission maxima of 404 and 477 nM, respectively; has been used for spatially restricted metabolite labeling and the detection of foodborne pathogens
Medchemexpress LLC Coumarin-C2-exo-BCN | 2488174-17-8 | 95.7% | 479.57 g·mol⁻¹ | C27H33N3O5 | 10 MG
Coumarin-C2-exo-BCN is a coumarin-derived fluorescent dye functionalized with an exo-BCN strained alkyne for bioorthogonal labeling via strain-promoted alkyne-azide cycloaddition (SPAAC). It is intended for catalyst-free conjugation to azide-containing biomolecules to generate fluorescent triazole-linked products.
- Fluorescent coumarin scaffold for sensitive detection.
- exo-BCN strained alkyne enables catalyst-free SPAAC with azides.
- Used to prepare fluorescent conjugates and label azide-containing biomolecules.
- Supplied as a solid with reported purity of ~95.7%.
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 500mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Medchemexpress LLC Coumarin-d4 | 185056-83-1 | 150.17 | 5 MG
Coumarin-d4 is the deuterium labeled version of Coumarin, which is the primary bioactive ingredient found in Radix Glehniae, also known as Beishashen in China. It exhibits various pharmacological activities, including anticancer, anti-inflammation, and antiviral properties. Deuterium substitution has the potential to affect the pharmacokinetic and metabolic profiles of drugs. It is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis through techniques such as NMR, GC-MS, or LC-MS.
Medchemexpress LLC 7-hydrazinyl-4-methyl-2H-chromen-2-one | 113707-87-2 | MFCD09999551 | 97.1% | 190.20 | C10H10N2O2 | 100MG
Coumarin hydrazine is a fluorescent chemical probe used to label protein- and lipid-bound carbonyls in cells and biochemical assays. It reacts with aldehydes and ketones to form fluorescent hydrazones, producing a measurable signal suitable for live-cell and in vitro labeling when handled protected from light (λex = 420-450 nm; λem ≈ 468 nm).
- Fluorogenic probe for labeling protein- and lipid-bound carbonyls.
- Reacts with aldehydes and ketones to form fluorescent hydrazones.
- Excitation 420-450 nm; emission ≈468 nm.
- Molecular formula C10H10N2O2; molecular weight 190.20.
- Purity 97.1%; supplied as a 100 mg solid.
- Protect from light; in solvent store at -80°C for up to 6 months or at -20°C for up to 1 month.
Sigma Aldrich Fine Chemicals Biosciences 7-Methoxycoumarin suitable for fluorescence, >=98.0% (TLC) | 531-59-9 | MFCD00006876 | 500MG
7-Methoxycoumarin suitable for fluorescence, >=98.0% (TLC) | Purity: >=98.0% (TLC) | Mol Wt: 176.17 | 531-59-9 | MFCD00006876 | 500MG
Sigma Aldrich Fine Chemicals Biosciences 7-Ethoxycoumarin | 31005-02-4 | MFCD00006877 | 25mg
7-Ethoxycoumarin | Purity: 99% | Mol Wt: 190.2 | 31005-02-4 | MFCD00006877 | 25mg
Medchemexpress LLC Coumarin-3-carboxylic acid | 531-81-7 | MFCD00006852 | 99.9% | 190.15 g/mol | C10H6O4 | 500 G
Coumarin-3-carboxylic acid is an aromatic coumarin derivative (C10H6O4, MW 190.15 g/mol) commonly used as a fluorescence probe for detection of hydroxyl radicals and as a synthetic intermediate in organic and medicinal chemistry. It is supplied in high purity suitable for research and is available in a range of laboratory pack sizes.
- Used as a fluorescence probe for hydroxyl radical detection
- Serves as a synthetic intermediate for coumarin derivatives
- High purity suitable for analytical and research use
- Available in multiple laboratory pack sizes, including bulk options
- Compatible with standard organic solvents for synthesis and analysis
Medchemexpress LLC MTX-531 | 2791417-66-6 | 99.87% | 453.94 | 100 MG
MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. It also acts as a weak agonist of PPARγ, with an IC50 of 2.5 μM, helping to alleviate hyperglycemia induced by PI3K inhibitors.
- Shows a concentration-dependent inhibitory effect on EGFR, P13K, and mTOR in CAL-33 cells.
- Activates PPARγ in 3T3-L1 cells.
- Inhibits EGFR and PI3K-mTOR pathway signaling in a time-dependent manner in mice.
- Suppresses tumor proliferation in mice.
- Shows excellent tolerance in mice and uniquely does not cause the hyperglycemia commonly seen with PI3K inhibitors.
- Enhances MEK inhibition in CRC.
- Combined with KRAS-G12C inhibitors, it suppresses tumor growth in mice with KRAS-G12C mutant colorectal cancer or pancreatic tumors.
AdipoGen Coumarin 334
Chemical. CAS 55804-67-6. Formula C17H17NO3. Molecular Weight 283.32. Coumarin 334 is a laser dye with an absorption maximum of 452nm. It is used as starting material for the synthesis of cysteine-selective or pH indicator fluorescent probes. Spectral data lambdamax 452nm, epsilon extinction coefficient >45000 at 449-455 nm in ethanol, lambdalaser 532nm.
eMolecules 185040-35-1 | 4-Ethylamino-2-methanethiopyrimidine-5-carboxaldehyde | 1g
Ambeed | 4-Fluoro-5-methoxy-1H-indole | 100mg | 561133591 | A355562 | 288385-89-7 | MFCD12924604 | 165.167 | C9H8FNO
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Cayman Chemical 7-AmIno-4-methylcoumarIn 500mg
A fluorescent probe for peptide labeling commonly used in the study of proteases; conjugation via its amino group to a peptide substrate results in quenching of the fluorescent signal; upon enzymatic cleavage of the peptide by proteases, AMC is released and its fluorescence can be used to quantify enzyme activity; ex/em = 345/445 nm, respectively
Cayman Chemical CoumarIn BoronIc AcId 50mg
A fluorescent probe for direct detection of peroxynitrite, hypochlorous acid, and hydrogen peroxide; reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s); COH displays ex/em = 332/470 nm, respectively