Coumarins and derivatives
Apexbio Technology LLC Palomid 529 914913-88-5 10mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Indofine Chemical 7-Hydroxycoumarin, 99%, 250 Mg
Molecular Formula: C10H6O5, Purity >99%, Molecular Weight: 206.16, Melting Point >270C, Appearance: Cream colored powder, Solubility: Soluble in DMF, Storage conditions: Store in a cool, dry place, Also known as 3-Carboxy-7-hydroxycoumarin
Cayman Chemical 7-EthoxycoumarIn 250mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
Cayman Chemical 7-EthoxycoumarIn 1g
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
Medchemexpress LLC Coumarin-C2-TCO | 2488174-16-7 | >98.0% | 455.55 | C25H33N3O5 | 10 MG
Coumarin-C2-TCO is a coumarin-derived fluorescent dye functionalized with a trans-cyclooctene (TCO) reactive handle that undergoes rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-bearing molecules for bioorthogonal labeling and conjugation.
- Fluorescent coumarin core provides a dye scaffold for imaging and detection.
- TCO reactive handle enables fast, bioorthogonal iEDDA conjugation to tetrazines.
- Suitable for labeling biomolecules and developing fluorescent probes in chemical biology workflows.
- Offered in small research quantities for synthesis and assay development.
TARGETMOL CHEMICALS INC 3-Aminocoumarin 50MG
Also available in 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. 3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes. Purity 99.54%
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | ≥97.0% | 220.18 | C11H8O5 | 1 G
7-Methoxycoumarin-3-carboxylic acid is a coumarin-derived fluorescent dye used to label peptides and other biomolecules for biochemical assays and HPLC derivatization. It is supplied as a solid with high purity and is prepared as a DMSO stock for use in fluorescence-based assays; handle and store protected from light.
- Excitation and emission in the near-UV/blue range (Ex ≈345-355 nm, Em ≈405-450 nm).
- Suitable for peptide labeling and HPLC derivatization.
- High purity appropriate for analytical applications (~97.0%).
- Soluble in DMSO (≈8 mg/mL with sonication and warming).
- Store protected from light; in solution, keep frozen for extended stability.
Apexbio Technology LLC Coumarin 6 38215-36-0 100mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Chem-Impex International, Inc. 4-Methylumbelliferyl acetate | MFCD00006865 | 1G
4-Methylumbelliferyl acetate, MFCD00006865, 1G
Apexbio Technology LLC Palomid 529 914913-88-5 50mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 1g
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays