Coumarins and derivatives
Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 1 MG
AZP-531 is an analogue of unacylated ghrelin for research use, designed to improve glycaemic control and reduce weight. It shows survival effects on pancreatic β-cells and human pancreatic islets, and is highly stable in human plasma in vitro with no degradation after one day at 37°C.
- Exhibits survival effects on pancreatic β-cells and human pancreatic islets.
- Stable in human plasma in vitro at 37°C for one day.
- Prevents high-fat diet-induced weight gain, proinflammatory effects, and prediabetic metabolic state in mice.
- Stimulates mitochondrial function markers in brown adipose tissue.
- Well-tolerated in clinical trials; improves glucose without increasing insulin.
- Reduces mean body weight and HbA1c in clinical trials.
Medchemexpress LLC Coumarin 6H | 58336-35-9 | 99.6% | 250 MG
Coumarin 6H is a coumarin-derived laser dye that functions as a fluorescent probe for spectroscopy and imaging applications. It exhibits enhanced fluorescence through hydrogen-bonding interactions, and is supplied as a solid powder for laboratory use.
- High purity fluorescent dye for analytical applications.
- Solid powder, yellow to brown appearance for easy handling and storage.
- Enhanced fluorescence emission via hydrogen bonding interactions.
- Available in small-scale package sizes suitable for research use.
- Store protected from light at low temperatures to maintain stability.
Medchemexpress LLC Linarin | 480-36-4 | 592.55 | 5 MG
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). It exhibits various activities such as anti-inflammatory, antioxidant, sleep aid, sedation, bone differentiation, anti-tumor, antibacterial, and antiviral properties. Linarin can be utilized in research for diseases like nervous system disorders, osteoporosis, and cancer.
- Orally active and selective inhibitor of acetylcholinesterase (AChE)
- Possesses anti-inflammatory activity
- Exhibits antioxidant properties
- Acts as a sleep aid and sedative
- Promotes bone differentiation
- Shows anti-tumor effects
- Demonstrates antibacterial activity
- Has antiviral properties
- Can be used to study nervous system diseases, osteoporosis, and cancer
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | 97.0% | 220.18 g·mol⁻¹ | C11H8O5 | 5 G
7-methoxycoumarin-3-carboxylic acid is a coumarin-derived fluorescent dye (CAS 20300-59-8) commonly used to label peptides and amines and for HPLC derivatization. It is a white to off-white solid (C11H8O5, MW 220.18 g·mol⁻¹) that exhibits blue fluorescence; optical properties are solvent- and pH-dependent and should be validated for the intended assay.
- Fluorescent label suitable for peptide and amine conjugation.
- Useful for HPLC derivatization and fluorescent detection.
- Blue fluorescence with excitation and emission peaks that vary by solvent and pH.
- Available as a solid, white to off-white powder for easy handling.
- Well-characterized chemical identity and molecular weight for reproducible results.
Medchemexpress LLC Coumarin 314 | 55804-66-5 | MFCD00051334 | 98.0% | 313.35 g·mol⁻¹ | C18H19NO4 | 100 MG
Coumarin 314 is a fluorescent dye exhibiting strong absorption in the visible region and pronounced solvent-dependent spectral properties. It is supplied as a light yellow solid and is used primarily as a research reagent in fluorescence measurements, probe design, and photophysical studies.
- Strong visible absorption and fluorescence.
- Pronounced solvent-dependent spectral behavior.
- High purity for research applications.
- Light yellow solid appearance for easy handling and identification.
- Suitable for photophysical and fluorescence probe studies.
Selleck Chemical LLC Palomid 529 (P529) S2238-1g
Palomid 529 (P529 SG 00529) inhibits both the mTORC1 and mTORC2 complexes reduces phosphorylation of pAktS473 pGSK3 S9 and pS6 Phase 1
Selleck Chemical LLC 7-Methoxycoumarin S5163-25mg
7-Methoxycoumarin (Herniarine) also known as Herniarin is a methoxy derivative of coumarin and substrate for dealkylase It has been used in the synthesis of anti-first-pass effect compounds and detergents
Apexbio Technology LLC Palomid 529 914913-88-5 50mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Medchemexpress LLC 6-Hydroxycoumarin | 6093-68-1 | 250 MG
6-Hydroxycoumarin is a coumarin exhibiting various biological activities, including anti-inflammatory, anti-pyretic, anti-oxidant, and vasodilator effects. It also demonstrates anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic, and antitumor properties.
- Exhibits anti-inflammatory activity
- Exhibits anti-pyretic activity
- Exhibits anti-oxidant activity
- Functions as a vasodilator
- Shows anti-amoebic activity
- Shows anti-bacterial activity
- Shows anti-fungal activity
- Acts as a bacteriostatic agent
- Exhibits antitumor activity
- For research use only
TARGETMOL CHEMICALS INC 3-Aminocoumarin 50MG
Also available in 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. 3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes. Purity 99.54%
Apexbio Technology LLC Coumarin 91-64-5 10mM (in 1mL DMSO)
Coumarin (91-64-5) is a small-molecule inhibitor targeting cytochrome P450 isoforms It is designed to modulate enzyme activity thereby regulating metabolic pathways Coumarin exerts its biological activity primarily through inhibition of cytochrome P450 enzymes In in vitro studies coumarin demonstrates enzyme inhibitory activity with an IC50 range of approximately 0 5 to 10 M depending on the isoform and experimental system Based on these pharmacological properties coumarin holds research potential in anticoagulant anti-inflammatory and anticancer agent discovery
Cayman Chemical 4-HydroxycoumarIn 250g
A coumarin; inhibits vitamin K1 epoxidation and prothrombin synthesis by 18 and 67%, respectively, in cell-free assays at 6.2 mM; has been used in the synthesis of anticoagulants, as well as antithrombotic, anti-inflammatory, antibacterial, and antifungal agents
Medchemexpress LLC HY-N0709 100mg Medchemexpress, Coumarin CAS:91-64-5 Purity:>98%
Medchemexpress, HY-N0709 100mg Coumarin CAS:91-64-5 Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Apexbio Technology LLC Esculin 531-75-9 20mg
Esculin (CAS 531-75-9) is a coumarin glucoside isolated from the bark of Aesculus hippocastanum It functions primarily as a -glucosidase substrate hydrolyzing to esculetin and glucose upon enzymatic action Esculin s fluorescence properties make it valuable in assays monitoring -glucosidase activity in microbiological and biochemical research Additionally its antioxidant and vasoprotective effects have supported investigations into microcirculatory disorders and oxidative stress-related models Esculin is soluble in hot ethanol methanol pyridine ethyl acetate and acetic acid and should be stored in sealed cool and dry conditions