Coumarins and derivatives
Medchemexpress LLC Esculetin | 305-01-1 | 99.79% | 178.14 | 1 ML
Esculetin is an active ingredient extracted mainly from the bark of *Fraxinus rhynchophylla*. It primarily functions by inhibiting the PI3K/Akt pathway, which affects platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching. Additionally, Esculetin demonstrates antioxidant, anti-inflammatory, and antitumor properties, making it a subject of various research applications. It is intended for research use only and not for medical or patient use.
- Inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cell (ASMC) proliferation and migration.
- Demonstrates antioxidant activity.
- Exhibits anti-inflammatory effects.
- Possesses antitumor activities.
- Targets PI3K pathway.
- Induces apoptosis in certain cancer cell types.
- Ameliorates skin lesions in psoriatic mice models.
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 25mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 5mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
![eMolecules Ambeed / 12-Bis((2R5R)-25-diethylphospholano)ethane(cyclooctadiene)rhodium(I) trifluoromethanesulfonate / 50mg / 650569995 / A1228631 / / 136705-71-0 / [null] / 670.550 / C27H44F3O3P2RhS](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502450445.PNG-250.jpg)
eMolecules Ambeed / 12-Bis((2R5R)-25-diethylphospholano)ethane(cyclooctadiene)rhodium(I) trifluoromethanesulfonate / 50mg / 650569995 / A1228631 / / 136705-71-0 / [null] / 670.550 / C27H44F3O3P2RhS
Ambeed / 12-Bis((2R5R)-25-diethylphospholano)ethane(cyclooctadiene)rhodium(I) trifluoromethanesulfonate / 50mg / 650569995 / A1228631 / / 136705-71-0 / [null] / 670.550 / C27H44F3O3P2RhS
Cayman Chemical CoumarIn BoronIc AcId 50mg
A fluorescent probe for direct detection of peroxynitrite, hypochlorous acid, and hydrogen peroxide; reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydrogen peroxide (k =1.5 M/s); COH displays ex/em = 332/470 nm, respectively
Apexbio Technology LLC Coumarin-3-carboxylic Acid 531-81-7 200mg
Coumarin-3-carboxylic Acid is a coumarin-derived small molecule commonly applied as an investigative tool in biomedical research focusing on signal pathway regulation It is utilized to modulate enzymatic activities and cellular signaling pathways Coumarin-3-carboxylic Acid s biological activity has been studied in the context of its lanthanide complexes for inhibitory effects on cell growth in K-562 cell lines In cell-based studies it demonstrates antiproliferative activity in K-562 cells Based on these pharmacological properties Coumarin-3-carboxylic Acid holds research potential in elucidating biological mechanisms underlying hematologic malignancies and related diseases
Medchemexpress LLC Coumarin hydrazine | 113707-87-2 | MFCD09999551 | 97.1% | 190.20 g/mol | C10H10N2O2 | 50MG
Coumarin hydrazine is an aromatic hydrazine-containing coumarin fluorophore used as a chemical probe to label protein- and lipid-bound carbonyls in cells. It excites in the 420-450 nm range and emits near 468-490 nm, and is provided as a solid reagent for research applications.
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 50mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
Chem-Impex International, Inc. 7-Hydroxy-4-methylcoumarin | 90-33-5 | MFCD00006866 | 25G
7-Hydroxy-4-methylcoumarin, 90-33-5, MFCD00006866, 25G
Medchemexpress LLC 2H-1-Benzopyran-2-one, 6-bromo- | 19063-55-9 | 225.04 | 10 G
6-Bromocoumarin (6-Bromochromen-2-one) is a chemical compound identified as a potential anti-bacterial agent. It has been noted for not inhibiting 17β-HSD1 and for showing affinity for α and β estrogen receptors.
- Potential anti-bacterial agent
- Does not inhibit 17β-HSD1
- Shows affinity for α and β estrogen receptors
Medchemexpress LLC 4-Hydroxycoumarin | 1076-38-6 | 250 G
4-Hydroxycoumarin is an orally active coumarin derivative and a versatile heterocyclic scaffold used in the synthesis of various organic compounds. It exhibits both electrophilic and nucleophilic properties. It is identified as an HIV protease inhibitor and tyrosine kinase inhibitor, and also demonstrates anti-inflammatory, antibacterial, and anti-tumor effects.
- Acts as an HIV protease inhibitor
- Acts as a tyrosine kinase inhibitor
- Exhibits anti-inflammatory effects
- Exhibits antibacterial effects
- Exhibits anti-tumor effects
- Disrupts actin cytoskeleton in B16-F10 melanoma cells
- Reduces adhesion and motility to extracellular matrix proteins
- Inhibits tumor growth and improves survival rate in melanoma mice
- Reduces symptoms in a rat model of trinitrobenzene sulfonic acid-induced colitis
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 10mg
A fluorogenic CYP450 substrate; a substrate for CYP1A1 and CYP1A2; metabolized to a lesser extent by CYP2D6 and CYP2C19; metabolized to 3-cyano-7-hydroxycoumarin and its fluorescence can be used to quantify CYP450 isoform activity
