Flavonoids
Apexbio Technology LLC (-)-epicatechin gallate 1257-08-5 20mg
(-)-Epicatechin gallate (ECG) is a catechin compound abundant in green tea displaying bioactivity to modulate cell proliferation apoptosis and gene expression pathways In colon HCT-116 cells ECG induces apoptosis through activating transcription factor 3 (ATF3) regulated via activation of early growth response protein 1 (EGR-1) In these cancer cells ECG upregulates apoptotic factor NAG-1 and increases caspase-3 activity at concentrations around 150 M ECG s cytotoxic potency differs among cell types with an NR50 (midpoint cytotoxic concentration) of approximately 67 M in HSC-2 oral cancer cells while normal human fibroblast HGF-2 cells show greater resistance with an NR50 near 100 M ECG metabolites identified in rat urine include various O-methylated derivatives useful as biomarkers for metabolism studies ECG serves as a research tool for oncology mechanisms and apoptosis signaling pathways
Medchemexpress LLC 3',4'-Dimethoxy-αNF | 14756-24-2 | MFCD00143008 | 98.5% | 332.35 | C21H16O4 | 5 MG
DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator provided as a research reagent. It is supplied as a light yellow solid or as DMSO solutions and intended for laboratory research use only.
- Selective aryl hydrocarbon receptor modulator used in AHR signaling studies.
- High purity (≈98.5%) suitable for biochemical assays.
- Molecular weight 332.35 and formula C21H16O4 for reference.
- Available in small solid quantities and as 10 mM DMSO solutions.
- Light yellow solid appearance for easy physical identification.
Cayman Chemical EpIgalocatechIn Galate 500mg
A phenol with diverse biological activities; lytic against T. cruzi amastigotes (MBC50 = 0.53 pM); decreases deoxyguanosine oxidation and tyrosine nitration (IC50s = 0.25 and 0.11 mM, respectively) and inhibits macrophage-mediated LDL oxidation in vitro; inhibits heregulin-β1-induced activation of ErbB2 and ErbB3, as well as migration and invasion of MCF-7 breast cancer cells; reduces food intake and body weight, serum levels of insulin, leptin, testosterone, and growth hormone, and the size of the ventral prostate, testis, liver, and spleen in male Sprague Dawley, lean Zucker and obese Zucker rats at 82, 81, and 92 mg/kg, respectively; reduces increases in hepatic steatosis, inflammatory cell infiltration, and injury in a mouse model of methionine- and choline-deficient diet-induced NASH at 50 and 100 mg/kg
Cayman Chemical Myricetin Natural Products Ext
A flavonoid compound that acts as a powerful antioxidant; inhibits TBARS formation with an IC50 value of 6.34 µM; blocks oxLDL uptake by U937-derived macrophages at 20 µM; demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit neoplastic transformation of murine JB6 Pt cells
Cayman Chemical Apigenin Inhibitors
Inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM; potent inhibitor of NO and PGE2 biosynthesis by reducing iNOS and COX-2 expression
Cayman Chemical Luteolin Inhibitors
A common dietary phenolic flavone; inhibits soybean and reticulocyte 15-lipoxygenases (IC50 = 0.6 µM); inhibits the release of TNFα from neutrophils; inhibits matrix metalloproteinases
Cayman Chemical Myricetin Natural Products Ext
A flavonoid compound that acts as a powerful antioxidant; inhibits TBARS formation with an IC50 value of 6.34 µM; blocks oxLDL uptake by U937-derived macrophages at 20 µM; demonstrates potent chemopreventative potential by binding JAK1/STAT3 to inhibit neoplastic transformation of murine JB6 Pt cells
Chem-Impex International, Inc. Quercetin | 117-39-5 | MFCD00006828 | 250G
Quercetin, 117-39-5, MFCD00006828, 250G
Medchemexpress LLC Engeletin | 572-31-6 | 434.39 | 50 MG
Engeletin is a flavanonol glycoside isolated from *Smilax glabra Roxb.*, which inhibits NF-κB signaling-pathway activation and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects. This compound is for research use only.
- Purity: 99.86%
- Formula: C21H22O10
- Appearance: Solid
- Color: White to yellow
- Structure classification: Flavonoids, Flavanonols, Phenols, Polyphenols
- Initial source: Plants (Liliaceae, Smilacis Glabrae Rhizoma), Microorganisms
- Solubility (in vitro): DMSO: ≥ 100 mg/mL (230.21 mM), H2O: < 0.1 mg/mL (insoluble)
TARGETMOL CHEMICALS INC AMG 487 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. Purity 99.89%