Flavonoids
Medchemexpress LLC 5,7,3',4'-Tetramethoxyflavone | 855-97-0 | 10 MG
5,7,3',4'-Tetramethoxyflavone is an orally active polymethoxyflavone (PMF) isolated from M. exotica. It possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. It also exhibits chondroprotective activity by targeting β-catenin signaling.
- Possesses anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory properties.
- Exhibits chondroprotective activity by targeting β-catenin signaling.
- Protects chondrocytes from ER stress-induced apoptosis.
- Decreases inflammatory cytokines.
- Inhibits chondrocyte hypertrophy.
Medchemexpress LLC Flavanone | 487-26-3 | 500 MG
Flavanone is a naturally occurring flavone with inhibitory activity for human estrogen synthetase (aromatase). It acts as an inhibitor for the ERK/p38/NF-κB signaling pathway and exhibits oral activity and antitumor efficacy.
- Naturally occurring flavone.
- Inhibits human estrogen synthetase (aromatase).
- Inhibits the ERK/p38/NF-κB signaling pathway.
- Exhibits oral activity.
- Shows antitumor efficacy.
Medchemexpress LLC Apigenin | 520-36-5 | 1 ML
Apigenin, also known as 4',5,7-Trihydroxyflavone, functions as a competitive inhibitor of CYP2C9 with a Ki of 2 μM. This compound has been observed to inhibit cell proliferation and suppress clone formation in various cell lines, making it suitable for research applications exploring its biological activity.
- Competitive CYP2C9 inhibitor
- Inhibits cell proliferation
- Suppresses clone formation of cells
Medchemexpress LLC Luteolin-7-rutinoside | 20633-84-5 | 5 MG
Luteolin-7-rutinoside possesses both anti-arthritic and antifungal activities, which can lead to a combination therapy for treating fungal arthritis caused by *C. albicans* infection. It is intended for research use only and not for sale to patients.
- Possesses anti-arthritic activity.
- Possesses antifungal activity.
- Reduces proliferation of T cells in a dose-dependent manner.
- Shifts Th1-Th2 balance away from Th1 towards Th2-type responses.
- Inhibits nitric oxide (NO) production from macrophages.
Medchemexpress LLC 5,7-Dimethoxyflavone | 21392-57-4 | 1 ML
5,7-Dimethoxyflavone is a major component of *Kaempferia parviflora* with diverse biological activities. It exhibits anti-obesity, anti-inflammatory, and antineoplastic effects. This compound acts as an inhibitor of cytochrome P450 (CYP) 3As and is a potent Breast Cancer Resistance Protein (BCRP) inhibitor.
- Exhibits anti-obesity, anti-inflammatory, and antineoplastic effects
- Acts as a potent inhibitor of CYP3A and BCRP
- Inhibits Bcrp1-mediated Sorafenib efflux
- Induces melanogenesis
- Inhibits lipid accumulation and adipocyte differentiation
- Reduces liver CYP3A11 and CYP3A25 protein expression
- Inhibits sarcopenia
- Decreases body weight gain and inhibits fatty liver
Medchemexpress LLC 7-Methoxyflavone | 22395-22-8 | 1 ML
7-Methoxyflavone is a flavonoid compound isolated from Zornia brasiliensis. It binds to human serum albumin and acts as an aromatase inhibitor. This compound demonstrates peripheral analgesic and certain antitumor activities, specifically effective against chemical pain but not thermal pain.
- Flavonoid compound
- Isolated from Zornia brasiliensis
- Binds to human serum albumin
- Acts as an aromatase inhibitor
- Exhibits peripheral analgesic activity
- Shows certain antitumor activities
- Effective against chemical pain
Cayman Chemical Hesperetin Natural Products Ex
A flavonoid with diverse biological activities; reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells from 10-200 µM; inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml); inhibits LPS-induced NO production and reduces levels of iNOS, IL-6, and IL-1β in BV-2 microglial cells; inhibits passive cutaneous anaphylaxis in mice at 5 mg/kg; reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis; reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation
Cayman Chemical ApIgenIn 7-glucosIde 50mg
A flavonoid with anti-inflammatory and anxiolytic activities; inhibits LPS-induced nitric oxide production in RAW 264.7 cells from 0.16-10 μM; reduces pulmonary edema and lung inflammation in a mouse model of LPS-induced acute lung injury at 10 mg/kg; increases the number of entries and the time spent in the open arms of the elevated plus maze in rats
Medchemexpress LLC Hesperidin methylchalcone | 24292-52-2 | 98.0% | 624.59 | 25 G
Hesperidin methylchalcone is an orally active flavonoid with analgesic, anti-inflammatory, and antioxidant properties. It exhibits vasoprotective activity and inhibits oxidative stress, cytokine production, and NF-κB activation. This compound can be utilized for research related to gout disease.
- Orally active flavonoid
- Analgesic properties
- Anti-inflammatory properties
- Antioxidant properties
- Vasoprotective activity
- Inhibits oxidative stress
- Inhibits cytokine production
- Inhibits NF-κB activation
- Can be used for the research of gout disease
Selleck Chemical LLC (-)Epicatechin S4723-1mg-5
( )Epicatechin (L-Epicatechin (-)-Epicatechol) is a flavonoid present in cocoa green tea and red wine It is a strong antioxidant has insulin mimic action and improves heart health
Apexbio Technology LLC 7,8-Dihydroxyflavone 38183-03-8 10mM (in 1mL DMSO)
7 8-Dihydroxyflavone (CAS 38183-03-8) is a small-molecule compound that acts as a selective agonist of the tropomyosin receptor kinase B (TrkB) By mimicking the action of brain-derived neurotrophic factor (BDNF) it activates TrkB-mediated signaling pathways resulting in enhanced neuronal survival and modulation of synaptic plasticity 7 8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies