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Puerarin is an isoflavone extracted from Pueraria root, functioning as a 5-HT2C receptor antagonist. It inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which leads to decreased fat absorption.
Acts as a 5-HT2C receptor antagonist
Inhibits LPS-induced iNOS, COX-2, and CRP protein and mRNA expression
Functions as a novel open-channel blocker of IK1
Alleviates hepatic damage from chronic alcohol administration
Improves early-stage renal damage in diabetic rats
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An isoflavonoid with antioxidant activity; scavenges peroxynitrite, nitric oxide radicals, and total ROS (IC50s = 1.36, 1.13, and 6.51 µM, respectively)
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5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. It inhibits the enzyme aromatase and acts as a non-steroidal anabolic isoflavone, demonstrating better potency in increasing muscle mass and endurance than Ipriflavone. It is also an inhibitor for NF-κB and can be used for fat loss, maintaining low cholesterol levels, and strengthening bones.
Orally active anti-oxidant
Inhibits aromatase enzyme
Non-steroidal anabolic isoflavone
Increases muscle mass and endurance
Supports fat loss
Helps maintain low cholesterol levels
Strengthens bones
Inhibits NF-κB
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A demethylated variant of necrostatin-1 that inhibits IDO; ~ 100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent than Nec-1 in a mouse necroptosis assay; inhibits TNF-induced systemic inflammatory response syndrome in vivo
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Genistein 7-sulfate sodium is a metabolite of genistein. It has the ability to reduce the activity of estrogen agonists in MCF-7 cells and can also promote the growth of MCF-7 cells at concentrations of 10 μM and above.
Metabolite of genistein
Reduces activity of estrogen agonists in MCF-7 cells
Promotes growth of MCF-7 cells at concentrations of 10 μM and above
Used in research on effects on estrogen agonists and MCF-7 cell growth
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Puerarin (CAS 3681-99-0) is an isoflavone compound isolated from the root of Pueraria lobata It exerts multiple pharmacological effects primarily through modulation of oxidative stress and inflammatory signaling pathways Puerarin has been reported to enhance myocardial perfusion protect against ischemic injury and regulate glucose and lipid metabolism in preclinical models Additionally it demonstrates neuroprotective properties including mitigation of neuronal damage associated with neurodegenerative conditions Puerarin is widely studied for its potential in cardiovascular metabolic and neurological disease research
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Also available in 1 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice it has significant antitumour activities the mechanisms are related to increased levels of caspase-3 caspase-7 caspase-9 and Bax and reduced levels Bcl-2. purity: 98%
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Puerarin (CAS 3681-99-0) is an isoflavone compound isolated from the root of Pueraria lobata It exerts multiple pharmacological effects primarily through modulation of oxidative stress and inflammatory signaling pathways Puerarin has been reported to enhance myocardial perfusion protect against ischemic injury and regulate glucose and lipid metabolism in preclinical models Additionally it demonstrates neuroprotective properties including mitigation of neuronal damage associated with neurodegenerative conditions Puerarin is widely studied for its potential in cardiovascular metabolic and neurological disease research
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More