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The transition metals possess partially-filled d sub-shells and are in groups 4 to 11 of the periodic table. They are hard, very conductive, have multiple oxidation states, display catalytic activity, and can form colored and/or paramagnetic compounds.
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Ro15-4513 is an imidazobenzodiazepinone derivative used in research that functions as a partial inverse agonist at GABAA (benzodiazepine) receptors and is widely used as an ethanol antagonist and reference standard.
Imidazobenzodiazepinone derivative acting on GABAA receptors.
Potent ethanol antagonist used in pharmacology and behavioral studies.
Off-white to yellow solid with high purity (~99.17%).
Molecular formula C15H14N6O3; molecular weight 326.31 g·mol⁻¹.
Recommended storage: powder at -20°C (long term) or 4°C (short term); in solvent at -80°C.
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PF-3450074 (PF-74) is a small-molecule inhibitor of the HIV-1 capsid protein used in laboratory research; it shows broad-spectrum, submicromolar inhibition and interferes with capsid-host factor interactions to block uncoating, assembly, and reverse transcription.
High purity suitable for research use (98.9%).
Molecular formula C27H27N3O2; molecular weight 425.52 g·mol-1.
Soluble in DMSO (up to 250 mg/mL); example in vivo formulation: 10% DMSO, 90% corn oil.
Recommended storage: powder at -20°C for long term, 4°C for short term; stock solutions at -80°C.
Intended for laboratory research only, not for human use.
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MT 63-78 is a small-molecule direct activator of AMP-activated protein kinase (AMPK) with an EC50 of 25 μM. It induces mitotic arrest and apoptosis, and inhibits lipogenesis and the mTORC1 pathway. Supplied as a solid for biochemical and cellular research.
Activates AMPK with an EC50 of 25 μM.
Induces mitotic arrest and apoptosis in cells.
Inhibits lipogenesis and the mTORC1 pathway.
Solid, light yellow to brown, purity 98.0%.
Soluble in DMSO (125 mg/mL); in vivo formulations available (≥2.08 mg/mL in recommended vehicles).
Storage: powder 4°C; in solution -80°C (6 months) or -20°C (1 month).
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BA-53038B is a hepatitis B virus (HBV) core protein allosteric modulator that binds the HAP pocket and modulates capsid assembly. It shows antiviral activity against HBV (EC50 = 3.32 μM) with low cytotoxicity (CC50 > 100 μM). Supplied as a solid research reagent with high reported purity and good solubility in DMSO.
Modulates HBV capsid assembly by binding the HAP pocket.
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MT 63-78 is a small-molecule research compound that functions as a direct activator of AMP-activated protein kinase (AMPK) and inhibits mTORC1 signaling. It induces mitotic arrest and apoptosis, and has reported antitumor effects, including blocking prostate cancer growth via suppression of lipogenesis and mTORC1 pathways.
Direct AMPK activator with reported EC50 25 μM
Induces mitotic arrest and apoptosis in cellular assays
Reported antitumor activity, including inhibition of prostate cancer growth
Molecular weight 326.35 g/mol; formula C21H14N2O2
Purity 98.0%
Available in 1 mg, 5 mg, 10 mg, 50 mg, 100 mg packs; store protected from light at 4°C (in solvent: -80°C for 6 months, -20°C for 1 month)
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