Phenols
Medchemexpress LLC Calmodulin Binding Peptide 1 | 104041-80-7 | 98.7% | 5301.10 | 25 MG
Calmodulin Binding Peptide 1 is a high-affinity (pM) CaM-binding peptide derived from smooth muscle myosin light chain kinase (MLCK peptide). The interface of the complex formed by Calmodulin Binding Peptide 1 and Ca2+-CaM can be specifically bound by small-molecule inhibitors, serving as a key target for selective regulation of smooth muscle contraction and development of anti-CaM drugs.
- High-affinity (pM) CaM-binding peptide.
- Derived from smooth muscle myosin light chain kinase (MLCK peptide).
- The complex with Ca2+-CaM can be specifically bound by small-molecule inhibitors.
- Serves as a key target for selective regulation of smooth muscle contraction.
- Used for the development of anti-CaM drugs.
- Binds to the human calmodulin fluorescent biosensor hCaM M124C-mBBr with high affinity (Kd = 2.55 ± 1.75 pM) in vitro.
- Can displace the lower-affinity inhibitor MBC from the biosensor.
Medchemexpress LLC Acridone | 578-95-0 | 195.22 | 500 G
Acridone is an organic compound based on the acridine skeleton. It possesses antibacterial, antimalarial, antiviral, and antineoplastic activities.
- Exhibits antibacterial, antimalarial, antiviral, and antineoplastic activities.
- Inhibits the proliferation of MDA-MB-231 cancer cells (0.1-1 μM, 48 h) and blocks the mRNA and protein expression of ATP binding cassette subfamily G member 2 (ABCG2).
Medchemexpress LLC 4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide | 882256-55-5 | MFCD00830676 | 99.8% | 320.39 g/mol | C19H20N4O | 10MM 1ML
iGOT1-01 is a small-molecule inhibitor of aspartate aminotransferase 1 (GOT1) intended for research use. It is supplied as a ready-to-use 10 mM solution in DMSO (1 mL) and is also available as a solid in various sizes. Key identifiers include CAS 882256-55-5, molecular formula C19H20N4O, and molecular weight ~320.4 g/mol. Reported purity is approximately 99.77%.
- Potent GOT1 inhibitor suitable for biochemical and cell-based assays.
- Provided as a 10 mM solution in DMSO for immediate use.
- Also available as a solid for custom formulation and storage.
- High reported purity suitable for research applications.
- Stable under recommended storage conditions for powder and solvent forms.
- Contains CAS 882256-55-5 for unambiguous identification.
Medchemexpress LLC Pardoprunox hydrochloride | 269718-83-4 | 99.5% | 269.73 | 50 MG
Pardoprunox (SLV-308) hydrochloride is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively. For research use only. We do not sell to patients.
- Pardoprunox hydrochloride acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with 50% efficacy on forskolin stimulated cAMP accumulation.
- At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist (intrinsic activity of 67%; pEC50=9.2) and antagonized dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0).
- Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3).
Medchemexpress LLC AChE-IN-27 | 177028-90-9 | 98.3% | 330.34 | 1 ML
AChE-IN-27 (compound 8c) is an AChE inhibitor with an IC50 of 0.19 μM. It is suitable for research in neurological diseases such as Alzheimer's disease, dementia, ataxia, and myasthenia gravis.
- AChE inhibitor (IC50=0.19 μM)
- Utilized in studies of neurological diseases
- Applicable for Alzheimer's disease research
- Used in studies for dementia, ataxia, and myasthenia gravis
Cell Signaling Technology Dinitrophenol (D1D6) Rabbit mAb 20 ul
Dinitrophenol (D1D6) Rabbit mAb 20 ul
Medchemexpress LLC GSK 690 Hydrochlorid 25mg | 2436760-79-9 | 405.92 | C24H24ClN3O | 25 MG
GSK 690 hydrochloride is a reversible inhibitor of lysine-specific demethylase 1 (LSD1) used as a research reagent in biochemical and cellular studies. It exhibits low nanomolar binding and biochemical potency and is supplied as a small-scale package for laboratory use.
- Reversible LSD1 inhibitor with Kd 9 nM and biochemical IC50 37 nM.
- High chemical purity (98.6%) for in vitro applications.
- Well characterized molecular properties (MW 405.92 g/mol, formula C24H24ClN3O).
- Intended for biochemical and cellular research use.
![eMolecules Ambeed / 666-(Benzene-135-triyl)tris(2-naphthoic acid) / 250mg / 650568498 / A1351827 / / 1383916-83-3 / [null] / 588.615 / C39H24O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502453672.PNG-250.jpg)
eMolecules Ambeed / 666-(Benzene-135-triyl)tris(2-naphthoic acid) / 250mg / 650568498 / A1351827 / / 1383916-83-3 / [null] / 588.615 / C39H24O6
Ambeed / 666-(Benzene-135-triyl)tris(2-naphthoic acid) / 250mg / 650568498 / A1351827 / / 1383916-83-3 / [null] / 588.615 / C39H24O6
Medchemexpress LLC I-191 | 1690172-25-8 | 99.1% | 423.48 | C23H26FN5O2 | 50 MG
I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist used as a research reagent to block PAR2-mediated signaling pathways in cell-based assays, resulting in reduced cytokine production and downstream effects such as Ca2+ mobilization and ERK1/2 phosphorylation.
- Potent, selective PAR2 antagonist.
- Inhibits PAR2-mediated Ca2+ release and ERK1/2 phosphorylation.
- Reduces cytokine production in cell-based assays.
- High purity (reported ~99.14%).
- Available in multiple pack sizes, including 50 MG.