Phenols
Medchemexpress LLC m-PEG24-NH2 | 2151823-08-2 | 99.9% | C49H101NO24 | 5 G
m-PEG24-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables selective degradation of target proteins
- Exploits the intracellular ubiquitin-proteasome system
STA PHARMACEUTICAL US LLC Fmoc-L-2,4-Dimethylphe | 25 g | CAS 1217728-65-8 | MDL MFCD06659141
Fmoc-L-2,4-Dimethylphe is a Amino Acid reagent (Subcategory: Phe) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1217728-65-8
- MDL: MFCD06659141
- InChIKey: MXBSNHLSKRVUBF-DEOSSOPVSA-N
- Molecular Weight: 415.489
- Molecular Formula: C26H25NO4
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(2,4-dimethylphenyl)propanoic acid
- SMILES: CC1=CC(C)=C(C=C1)C[C@@H](C(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O
Medchemexpress LLC M-CSF Human 223a.a 1mg
Recombinant human macrophage colony-stimulating factor (M-CSF), 223 amino acids, produced in HEK293 cells with a His tag. Supplied lyophilized with lot-specific formulation, the protein is biologically active for promoting macrophage proliferation and differentiation (ED50 2-10 ng/mL). Endotoxin level is low (<0.01 EU/μg). Store at -20°C; after reconstitution stable at 4°C for one week or frozen for long-term storage.
- Promotes macrophage proliferation and differentiation in vitro.
- High specific activity with ED50 of 2-10 ng/mL.
- Low endotoxin level, <0.01 EU/μg.
- Lyophilized format for stable storage and transport.
- Produced in HEK293 cells to support native glycosylation.
- Recommended storage at -20°C; aliquot and freeze for long-term use.
Medchemexpress LLC BirA protein, Escherichia coli (N-His, N-MBP tagged) | >95.0% | 50 UG
BirA protein, Escherichia coli (His-MBP) is a recombinant biotin ligase expressed in Escherichia coli with N-terminal 6xHis and maltose-binding protein (MBP) tags. It catalyzes site-specific biotinylation of an Avi-tag acceptor peptide in the presence of ATP, enabling selective labeling, capture, and immobilization of target proteins for biochemical and affinity applications.
- Enables site-specific biotinylation in the presence of ATP.
- Supplied as lyophilized powder for convenient storage and transport.
- N-terminal His and MBP tags facilitate purification and improve solubility.
- Purity greater than 95% by reducing SDS-PAGE.
- Stable long-term at -20 °C; aliquot and store at -80 °C for extended stability.
- Suitable for labeling, affinity capture, and biochemical assays.
Medchemexpress LLC 2OH-BNPP1 | 833481-73-5 | MFCD28120704 | 99.7% | 297.35 g/mol | C16H19N5O | 10 MG
2OH-BNPP1 is a small-molecule inhibitor of the BUB1 serine/threonine kinase supplied for research use. It is provided as a high-purity solid suitable for in vitro and in vivo studies, with documented solubility profiles and recommended storage conditions to preserve stability.
- High purity (99.65%).
- Molecular formula C16H19N5O; molecular weight 297.35 g/mol.
- CAS number 833481-73-5.
- White to off-white solid appearance.
- Soluble in DMSO (100 mg/mL) and can be formulated for in vivo use.
- Recommended storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (2 years).
- Available in multiple pack sizes, including a 10 mg pack.
STA PHARMACEUTICAL US LLC Fmoc-L-3,4-Dimethylphe | 25 g | CAS 1217620-19-3 | MDL MFCD08458428
Fmoc-L-3,4-Dimethylphe is a Amino Acid reagent (Subcategory: Phe) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1217620-19-3
- MDL: MFCD08458428
- InChIKey: QMHIEEWTOGXGNA-DEOSSOPVSA-N
- Molecular Weight: 415.489
- Molecular Formula: C26H25NO4
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3,4-dimethylphenyl)propanoic acid
- SMILES: O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)N[C@@H](CC4=CC=C(C)C(C)=C4)C(O)=O
Cayman Chemical EA4 Fatty Acids and Derivative
An inhibitor of PLA2 from red blood cells (Ki = 130 µM); inhibits the ionophore-induced arachidonic acid release from human and bovine RBCs; induces mRNA expression and increases protein levels of CYP1A1 in murine hepatoma Hepa-1c1c7 cells; modulates CYP1A1 and CYP1B1 expression in MCF-7, Hep-G2, and HL-60 cells
Apexbio Technology LLC EZ Cap Mouse CD252(OX40L) mRNA (m1Ψ HA tag) 5x1mg (1mg/mL)
Mouse CD252 mRNA encodes cytokine OX40 ligand (OX40L) expressed on the surface of activated antigen-presenting cells such as dendritic cells B cells and macrophages Binding to the OX40 receptor (CD134) the CD252-OX40 signaling pathway plays a key role in the immune system promoting T cell proliferation survival and effector functions This signaling pathway significantly influences immune response regulation immune tolerance maintenance and anti-tumor immunity CD252 is involved in the pathological processes of autoimmune diseases and chronic inflammation EZ Cap Mouse CD252 (OX40L) mRNA (m1 HA tag) is provided at 1 mg/mL It expresses mouse-derived CD137 cytokine tagged with HA facilitating subsequent detection It contains a cap 1 structure generated via co-transcriptional capping Incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vivo
Medchemexpress LLC IHMT-MST1-39 | 2414484-01-6 | 99.68% | 460.46 | 1 ML
IHMT-MST1-39 is an orally active inhibitor for MST kinase. It activates the AMPK signaling pathway in liver cells and reduces apoptosis of pancreatic β-cells, making it suitable for studies related to type 1 and type 2 diabetes.
- Blocks pancreatic β-cell apoptosis through MST1 inhibition
- Enhances pancreatic β-cell function and survival under diabetogenic conditions
- Activates AMPK signaling in HepG2 and HL7702 cells
- Reversed diabetic symptoms in a Streptozotocin (STZ)-induced T1D mouse model
- Prevented diabetic hyperglycemia in T2D mouse models
- Significantly reduced fasting blood glucose and improved glucose tolerance
- Lowered HbA1c levels and protected pancreatic islet structure and beta cell mass
- Improved glycemic control in spontaneous T2D models and HFD/STZ-induced T2D models
- Significantly improved insulin resistance
Medchemexpress LLC (2-chlorophenyl)(phenyl)methanone | 5162-03-8 | MFCD00000558 | 98.8% | 216.67 g/mol | C13H9ClO | 500 G
(2-Chlorophenyl)(phenyl)methanone (2-chlorobenzophenone) is an aromatic ketone used as a biochemical reagent and organic synthesis intermediate for life-science research. It is supplied as a solid of high purity, suitable for laboratory synthesis, analytical work, and reagent applications.
- High purity solid suitable for laboratory use.
- Molecular formula C13H9ClO; molecular weight 216.67 g/mol.
- Common applications include organic synthesis and biochemical assays.
- Available in multiple pack sizes for scalable use.
- Stable under normal laboratory storage conditions.
Apexbio Technology LLC EZ Cap Mouse IL-23α mRNA (m1Ψ HA tag) 100ug (1mg/mL)
Mouse IL-23 mRNA encodes a subunit of interleukin-23 (IL-23) IL-23 has two subunits p19 (IL-23 ) and p40 IL-23 binds p40 to form a functional cytokine promoting differentiation and maintenance of Th17 cells which are essential in anti-microbial defense and autoimmune diseases Dysregulated expression of IL-23 is associated with multiple inflammatory diseases such as psoriasis Crohn s disease and multiple sclerosis IL-23 and its subunit IL-23 are therapeutic targets for these diseases and numerous biologics have been developed to inhibit their activity EZ Cap Mouse IL-23 mRNA (m1 HA tag) is provided at 1 mg/mL encoding mouse IL-23 cytokine fused with an HA tag enabling convenient downstream detection of expressed proteins With cap 1 structure generated through co-transcriptional capping incorporation of modified nucleotides m1 along with a poly (A) tail minimizes RNA-induced innate immune activation and enhances mRNA stability and lifespan both in vitro and in vi
Medchemexpress LLC M-CSF Cynomolgus/Rh 50ug
The M-CSF protein regulates hematopoietic precursor cells promoting their survival proliferation and differentiation M-CSF Protein Cynomolgus/Rhesus Macaque (HEK293 Fc) is the recombinant Rhesus Macaque cynomolgus-derived M-CSF protein expressed by HEK293 with C-hFc labeled tag
BIOHIPPO h/m BCL-xL-sh-BSD
h/m BCL-xL-sh-BSD shRNA lentiviral vector expressing with Blasticidin selection for studies in Human/Mouse Each vial provides a nominal titer of 5x10E6 transducing units TU Validated h/m BCL-xL shRNA Lentivirus High-titer shRNA lentiviral particles specific for human/mouse BCL2 like 1 (BCL-xL) The shRNA has been validated to meet or exceed 70% BCL-xL knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene ( 70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs