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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
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Rose Bengal (CAS 632-69-9) is a small-molecule inhibitor targeting vesicular glutamate transporter (VGlut) and vesicular monoamine transporter (VMAT) It is designed to inhibit the uptake and storage of glutamate into synaptic vesicles thereby modulating neurotransmitter storage and release Rose Bengal exerts its biological activity primarily through inhibition of glutamate uptake into vesicles without affecting H -ATPase pump activity In vitro experiments demonstrate inhibitory activity with reported Ki values of approximately 19 nM for VGlut and 64 nM for VMAT in isolated synaptic terminals Based on these pharmacological properties Rose Bengal holds research potential in neurobiochemical studies exploring neurotransmitter release and synaptic vesicle trafficking
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E 2012 is a small-molecule γ-secretase modulator used in preclinical research to reduce amyloid β-42 and to probe cholesterol biosynthesis via DHCR24 inhibition. Supplied for laboratory use as a concentrated solution in DMSO, it is intended for in vitro and related studies.
Potent γ-secretase modulator activity.
Reduces amyloid β-42 levels in cellular assays.
Inhibits 3β-hydroxysterol Δ24-reductase (DHCR24).
Available as a 10 mM solution in DMSO (1 mL) and as solid formats.
High solubility in DMSO (~119 mM) with ultrasonic assistance.
Manufacturer-reported purity approximately 97.0% and defined storage conditions.
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di-Pal-MTO is a palm oil-based lipid created by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they effectively deliver siRNA to cells and enhance anticancer activity.
Effective siRNA cell delivery
Enhances anticancer activity
Reduces tumor cell viability by 81% in vitro
Reduces tumor size by 83% in vitro
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1-Bromo-3-chlorobenzene-d4 (3-Chlorobromobenzene-d4) is a deuterium labeled 1-Bromo-3-chlorobenzene. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Used as a tracer.
Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
For research use only.
Store at room temperature for 3 years; in solvent: -80°C for 2 years, -20°C for 1 year.
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