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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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Zaldaride maleate is a research-grade calmodulin inhibitor used in biochemical and pharmacological studies to block calmodulin-mediated signaling. It is described as a potent, orally active, and selective antagonist of calmodulin and is applied in cellular assays and mechanistic investigations involving CaM-dependent pathways.
Potent calmodulin inhibition for mechanistic studies.
High purity suitable for research applications.
Supplied in small-mass formats for dose-ranging experiments.
Solid storage recommended at 4°C; solutions stable at -20°C to -80°C per guidance.
Molecular weight approximately 544.6 g/mol for dosing calculations.
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(S)-( )-Dimethindene maleate (CAS 136152-65-3) is a small molecule antagonist exhibiting selective affinity for the muscarinic acetylcholine receptor subtype M2 while showing comparatively reduced interaction with M1 M3 and M4 subtypes Additionally it acts as an antagonist at histamine H1 receptors Due to its receptor selectivity profiles it is employed in pharmacological studies investigating autonomic regulation mechanisms cardiovascular physiology and respiratory system function
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Indacaterol maleate (QAB149) is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. It inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing lung damage and improving lung function in chronic obstructive pulmonary disorder (COPD). It also shows promise in cardiovascular disease research, normalizing and reversing cardiac remodeling in a myocardial infarction rat model of heart failure.
Inhibits NF-κB activity in a β-arrestin2-dependent manner.
Helps prevent lung damage.
Improves lung function in chronic obstructive pulmonary disorder (COPD).
Used in cardiovascular disease research.
Normalizes and reverses cardiac remodeling in myocardial infarction rat models.
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Neratinib maleate is an orally available, irreversible, and highly selective inhibitor of HER2 and EGFR, intended for research use only. It inhibits the proliferation of cell lines expressing high levels of HER-2 and demonstrates anticancer activities in vivo by reducing tumor growth in a dose-dependent manner in various xenografts.
Orally available, irreversible, highly selective HER2 and EGFR inhibitor.
Inhibits proliferation of cell lines with high HER-2 levels.
Arrests cell cycle at G1-S phase.
Inhibits MAPK and Akt phosphorylation.
Down-regulates cyclin D1 levels and induces p27.
Shows anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
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Omigapil maleate (CGP3466B) is an orally active GAPDH nitrosylation inhibitor that abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. It has potential for Alzheimer's disease research and is also an apoptosis inhibitor. Additionally, it can be used for congenital muscular dystrophy (CMD) research.
Orally active GAPDH nitrosylation inhibitor.
Abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice.
Potential for Alzheimer's disease research.
Apoptosis inhibitor.
Can be used for congenital muscular dystrophy (CMD) research.
Click chemistry reagent with an alkyne group for CuAAc reactions.
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L-693 403 maleate (CAS 207455-21-8) is a small molecule exhibiting high affinity and selectivity for sigma ( ) receptors By modulating receptor-mediated signaling pathways it influences neuronal signal transduction at the molecular level Preclinical studies indicate that L-693 403 maleate possesses analgesic properties likely through its regulatory effects on neural activity Owing to these pharmacological characteristics it is utilized in exploratory research on neurological disorders supporting its value as a tool compound in the investigation of neural modulation mechanisms
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